iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018638

UUCD1 version

UUC-CaE-00210

Ensembl Protein ID

D2085.4

UniProt Accession

O17736; Q18992; O17736_CAEEL

Genbank Protein ID

CAA91061.1

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BX284602

Gene Name

CELE_D2085.4; D2085.4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00008429	D2085.4	D2085.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	23578927

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	4.60e-93	312.6	660	1000

Active Site

Position(s)	Description	Evidence
969	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfy 97
           +dlk+ ++v++v+     E+g+d gG++refl++l+k  +n + g+f+++e++    +p     l   + l +F+f+Gr++gk +++++l +++++++f+
   Q: 660  NDLKSMVRVKMVNwagmnESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLL-GVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFI 758
           6899999999999999*9********************************988888888888777.45******************************** PP
   S: 98   klllgk....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveaf 193
            +++++    +++l++++++dp ++k+lk ++++++++++el+ld+++   ++ +g +++++Lkp+G++ +Vt eN +eYv+l+v+y+lk++i+++v+a+
   Q: 759  AQIFETdknkDVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSV--VTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAV 856
           ***98866668***********************88788877666665..5777********************************************** PP
   S: 194  reGfneviplellslFteeelellicGe.eeidvedlkket..kykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvir 290
           r+G++e+i++e++++F ++el+++i G  e +++++l+k++  ++  g+++ + + ++Fw+v+ ++s++++ka+L+FvTg+sr+P+ Gf++++pr+ v+ 
   Q: 857  RKGISEIISIEWMRMFAPHELQIMIAGYeEVFTAKELRKFCelRFAAGTQDINYE-EMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLV 955
           ****************************8889********978889988888888.9***************************************9999 PP
   S: 291  kdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
             +sdd+lP+s TC+n+L++P+Ys+ ++l+ekL+yAi++++gFel
   Q: 956  IPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFEL 1000
           999****************************************98 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MIKSLNERDN FLNRLREMEH KREKDEKQEK AARKVQKFWR GHRVQHNQRL LFRAEFDAVS 60
DRQRGLEETI KMAQLLVNFY ETNKDEERLV MTLSELVKLK TSDKEFEKRI RETQRLLLAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGTCATT CAACCTGGTA TTTTTTAACG GTGATGTTCG GAGGGACAAA AAACAGGAAG 60
CAATGATCAA AAGCCTAAAC GAGCGGGACA ACTTTCTTAA CAGACTCCGC GAAATGGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061631--F:ubiquitin conjugating enzyme activity
GO:1902104--P:positive regulation of metaphase/anaphase transition of meiotic cell cycle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_D2085.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	39.61	1.00e-89	323.00
IUUC-Apl-003731	Anas platyrhynchos	40.10	2.00e-92	332.00
IUUC-Aca-005248	Anolis carolinensis	40.34	2.00e-92	332.00
IUUC-Ame-010769	Astyanax mexicanus	35.77	3.00e-69	255.00
IUUC-Bta-012841	Bos taurus	39.37	3.00e-90	325.00
IUUC-Cja-019743	Callithrix jacchus	40.00	5.00e-90	324.00
IUUC-Cfa-021031	Canis familiaris	39.61	4.00e-90	325.00
IUUC-Cpo-022401	Cavia porcellus	39.37	1.00e-89	323.00
IUUC-Csa-024107	Chlorocebus sabaeus	40.58	8.00e-92	330.00
IUUC-Dre-028196	Danio rerio	38.65	4.00e-90	325.00
IUUC-Dno-029024	Dasypus novemcinctus	39.86	6.00e-91	327.00
IUUC-Eca-033828	Equus caballus	39.86	1.00e-90	327.00
IUUC-Eeu-034604	Erinaceus europaeus	42.65	1.00e-41	164.00
IUUC-Fca-035907	Felis catus	39.61	6.00e-90	324.00
IUUC-Fal-037389	Ficedula albicollis	39.86	1.00e-91	330.00
IUUC-Gga-040310	Gallus gallus	39.61	1.00e-91	330.00
IUUC-Ggo-045031	Gorilla gorilla	40.34	2.00e-91	329.00
IUUC-Hsa-045880	Homo sapiens	40.34	2.00e-91	329.00
IUUC-Lch-050403	Latimeria chalumnae	39.66	2.00e-78	286.00
IUUC-Loc-052218	Lepisosteus oculatus	32.44	6.00e-90	324.00
IUUC-Laf-054162	Loxodonta africana	37.91	8.00e-62	231.00
IUUC-Mcc-055127	Macaca mulatta	40.34	2.00e-91	329.00
IUUC-Mga-059581	Meleagris gallopavo	39.86	7.00e-92	330.00
IUUC-Mmr-061360	Microcebus murinus	39.86	6.00e-91	327.00
IUUC-Mdo-062194	Monodelphis domestica	39.86	1.00e-90	327.00
IUUC-Mmu-064189	Mus musculus	39.86	3.00e-90	325.00
IUUC-Mpu-066439	Mustela putorius furo	39.37	2.00e-89	323.00
IUUC-Mlu-068228	Myotis lucifugus	39.37	6.00e-90	324.00
IUUC-Nle-069687	Nomascus leucogenys	40.19	5.00e-91	328.00
IUUC-Ont-071836	Oreochromis niloticus	38.65	8.00e-89	320.00
IUUC-Oan-072800	Ornithorhynchus anatinus	40.10	5.00e-92	331.00
IUUC-Ocu-074587	Oryctolagus cuniculus	40.10	2.00e-91	329.00
IUUC-Ola-087209	Oryzias latipes	32.34	4.00e-90	325.00
IUUC-Oga-088776	Otolemur garnettii	39.37	4.00e-90	325.00
IUUC-Oar-089441	Ovis aries	39.37	4.00e-90	325.00
IUUC-Ptr-091273	Pan troglodytes	40.34	2.00e-91	329.00
IUUC-Pan-091981	Papio anubis	40.34	2.00e-91	329.00
IUUC-Psi-093203	Pelodiscus sinensis	41.20	2.00e-62	233.00
IUUC-Pma-094738	Petromyzon marinus	40.24	3.00e-90	325.00
IUUC-Pfo-097511	Poecilia formosa	39.28	2.00e-90	326.00
IUUC-Pab-098634	Pongo abelii	38.01	8.00e-83	300.00
IUUC-Rno-105380	Rattus norvegicus	41.58	4.00e-64	238.00
IUUC-Sha-107108	Sarcophilus harrisii	37.44	4.00e-81	295.00
IUUC-Sar-113687	Sorex araneus	40.34	2.00e-59	222.00
IUUC-Ssc-115378	Sus scrofa	39.81	4.00e-67	247.00
IUUC-Tgu-116729	Taeniopygia guttata	39.86	6.00e-91	327.00
IUUC-Tru-118068	Takifugu rubripes	39.52	2.00e-89	323.00
IUUC-Tni-120732	Tetraodon nigroviridis	38.55	5.00e-83	301.00
IUUC-Tbe-127351	Tupaia belangeri	39.39	3.00e-76	279.00
IUUC-Xtr-132094	Xenopus tropicalis	39.37	4.00e-90	325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence