iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000004960.3	ENSCJAT00000009599.2	ENSCJAP00000009086.2
ENSCJAG00000004960.3	ENSCJAT00000060034.1	ENSCJAP00000042042.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.30e-127	426.4	1062	1495

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 206  eeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaalta 290
           +e +   ++++++++t+L+ +ve+++++       +++ a++r k++++ +++++L++r+ +  ++++l++++++++++q+ ++lt+
   Q: 1062 PEPRPQLFFSRVRRLTHLV-HVEPCEAP-------PPVAATPRPKGRNRSHDWSSLATRGFPssIMRNLTRCWQAVVEKQVDNFLTS 1140
           5666677899*******96.89******.......*************************9999*********************** PP
   S: 291  eekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaql 376
           +++++d   +V+r++e++n lq+++se+F+++a+Fl al+++++ +++k ++lkaa+++E++Ar+iDq++++s ++g++e+e +aql
   Q: 1141 SWRDDD---FVPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSrIGGAQEMERLAQL 1224
           ******...****************************************************************************** PP
   S: 377  dkvllvfkyisekdv...FekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk....... 452
           +++l+++ ++s++++   Fe+yY++++a+RLl   ++ss++E++v+e++    g++f+++L ++M+q+l++S++l+rqF+       
   Q: 1225 QQCLEAVLIFSGLEIattFEHYYQHYMADRLLG--VFSSWLEGAVLEQI----GPCFPNRLpQQMLQNLSTSKELQRQFHvyqlqrl 1305
           *********************************..**************....********************************** PP
   S: 453  ..............................................eekenteesesvelsvlvLsagaWpta..set..ekvsLPa 489
                                                         e+++ ++e +++e+svlvLs+++Wp+a  ++t  ++++LP+
   Q: 1306 dqellkledtekkiqvdheasgkehksekeegagaaaavdaaeeeeENEDLYYEGAMPEVSVLVLSRHCWPVAsiCHTlnPRTCLPS 1392
           ********************************************98889999*********************9999899******* PP
   S: 490  elektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeL 568
           +l+ t++++++fY        le++s+R+LqW++ lg+ael++    g+++lqVst+Qm++LL++n+ +++sve+l + ++l+++ L
   Q: 1393 YLSGTLNRYSNFYnksqshpaLERGSQRRLQWTW-LGWAELQF----GNQTLQVSTVQMWLLLYLNDLKSISVESLLALSGLSADTL 1474
           **********************************.********....**************************************** PP
   S: 569  rrtlqsLvssk..kqvlkkep 587
           ++++++L+ss+   +++++++
   Q: 1475 NQAIGPLTSSRgpLDLHEQKD 1495
           *********997777776655 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GDGVAGQVDC 60
KAEHILLWMS KDEIYANCHK MLGEDGQVIR PSQSAGEVGA LDKSVLEEME TDVKSLIQRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AACTCCGCTA CAGGGAATTC AGGGTGCCCC TGGGGCCTGG CTTACATGCC 60
TATCCTGATG AGCTGATCCG CCAGCGAGTG GGCCATGATG GGCATCCTGA GTACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	82.67	0.00e+00	2620.00
IUUC-Bta-013285	Bos taurus	80.83	0.00e+00	2590.00
IUUC-Cfa-020695	Canis familiaris	81.57	0.00e+00	1627.00
IUUC-Cpo-021513	Cavia porcellus	76.01	0.00e+00	2351.00
IUUC-Csa-023798	Chlorocebus sabaeus	91.34	0.00e+00	2877.00
IUUC-Dno-029587	Dasypus novemcinctus	76.83	0.00e+00	1357.00
IUUC-Dor-030234	Dipodomys ordii	81.14	0.00e+00	2630.00
IUUC-Ete-032612	Echinops telfairi	76.78	0.00e+00	884.00
IUUC-Eca-033408	Equus caballus	85.31	0.00e+00	2642.00
IUUC-Fca-035483	Felis catus	82.35	0.00e+00	2633.00
IUUC-Gac-041628	Gasterosteus aculeatus	45.01	0.00e+00	1281.00
IUUC-Ggo-044721	Gorilla gorilla	91.40	0.00e+00	2827.00
IUUC-Hsa-046406	Homo sapiens	91.58	0.00e+00	2881.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	83.48	0.00e+00	2602.00
IUUC-Lch-049956	Latimeria chalumnae	42.72	0.00e+00	998.00
IUUC-Laf-054068	Loxodonta africana	81.52	0.00e+00	2624.00
IUUC-Mcc-055464	Macaca mulatta	91.46	0.00e+00	2872.00
IUUC-Meu-056198	Macropus eugenii	53.81	0.00e+00	1494.00
IUUC-Mmr-061464	Microcebus murinus	84.31	0.00e+00	2634.00
IUUC-Mdo-062018	Monodelphis domestica	56.31	0.00e+00	1282.00
IUUC-Mmu-063413	Mus musculus	74.61	0.00e+00	2263.00
IUUC-Mpu-066146	Mustela putorius furo	84.19	0.00e+00	2553.00
IUUC-Mlu-067036	Myotis lucifugus	81.31	0.00e+00	2597.00
IUUC-Opr-070670	Ochotona princeps	75.32	0.00e+00	2331.00
IUUC-Oan-073451	Ornithorhynchus anatinus	49.56	0.00e+00	1094.00
IUUC-Ocu-074155	Oryctolagus cuniculus	81.59	0.00e+00	2534.00
IUUC-Oga-089084	Otolemur garnettii	83.89	0.00e+00	2712.00
IUUC-Oar-090029	Ovis aries	82.48	0.00e+00	2605.00
IUUC-Ptr-091282	Pan troglodytes	90.12	0.00e+00	2867.00
IUUC-Pan-091883	Papio anubis	91.57	0.00e+00	2897.00
IUUC-Pab-098383	Pongo abelii	87.91	0.00e+00	2781.00
IUUC-Pca-100519	Procavia capensis	74.21	0.00e+00	815.00
IUUC-Pva-102417	Pteropus vampyrus	81.37	0.00e+00	2121.00
IUUC-Rno-105962	Rattus norvegicus	76.78	0.00e+00	2388.00
IUUC-Sar-113750	Sorex araneus	80.73	3.00e-171	596.00
IUUC-Ssc-115899	Sus scrofa	77.74	0.00e+00	2315.00
IUUC-Tbe-127660	Tupaia belangeri	84.86	0.00e+00	1412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence