iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098383

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cullin-7

Genbank Nucleotide ID

ABGA01085102

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000016629.2	ENSPPYT00000019337.2	ENSPPYP00000018598.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	5.40e-129	431.8	1002	1544

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++++ed +++ll+l+++l+ a+R+++++++r+l++ +++    
   Q: 1002 PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDMAED-RRSLLHLSSRLNGALRQEQNFADRFLPDNEAA---- 1066
           589***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea +n++++  a++++++++t+Ll++ve e  +        +
   Q: 1067 ----QALGKTCWEALVSPVVQNITSPDEDGISPLgWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVECEAPP--------P 1141
           ....9*******************************************************************977655........* PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +va++r k++++ +++++L++r+l+  ++++l++++++++++q++++lt++++++d   +    +e    +   + +++n+++    
   Q: 1142 VVATPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEKQVNNFLTSSWRDDD---FT--QCEKTLSIIVNIANLYNPRPSSPL 1223
           ************************999*****************************...54..477777777778899999998877 PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           +   ++  + +       a+++E++Ar+iDq++++s ++g++e+e +aql+++l+++ ++s++++   Fe+yY++++a+RLl   ++
   Q: 1224 TCSAGLFMAFLCS---AIAQVSEQFARHIDQQIQGSrIGGAQEMERLAQLQQCLQAVLIFSGLEIattFEHYYQHYMADRLLG--VV 1305
           7776654444444...389****************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+q+l++S++l+rqF+                                            
   Q: 1306 SSWLEGAVLEQI----GPCFPNRLpQQMLQSLSTSKELQRQFHvyqlqqldqellkledtekkiqvghgasgkehksekeeeagaaa 1388
           ************....*********************************************************************** PP
   S: 453  ............eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqh 515
                       e+++ ++e +++e+svlvLs+++Wp+a  ++t  ++++LP++l+ t++++++fY        le++s+R+LqW++
   Q: 1389 avdvaegeeeeeENEDLYYEGAMPEVSVLVLSRHCWPVAsiCHTlnPRTCLPSYLRGTLNRYSNFYnksqshpaLERGSQRRLQWTW 1475
           **********98889999*********************9999899***************************************** PP
   S: 516  tlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkep 587
            lg+ael++    g+++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L++++++L+ss+   +++++++
   Q: 1476 -LGWAELQF----GNQTLHVSTVQMWLLLYLNDLKAVSVESLLALSGLSADMLNQAIGPLTSSRgpLDLHEQKD 1544
           .********....*************************************************997777776655 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE GDGGSGQVDC 60
KAEHILLWMS KDEIYANCHK MLGEDGQVIG PSQESTGEVG ALDKSVLEEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACGTGTGG TGTGCTACTG CGGAAGGTGA ATGGCACAGC CATTATCCAG CTGCCCTCTA 60
AGAGGCAGAT GCAGGTGTGT ATGGGTATGG GTGGGAGGGG TCAGCAAAGG AGGAATTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	83.05	0.00e+00	2637.00
IUUC-Bta-013285	Bos taurus	83.87	0.00e+00	2655.00
IUUC-Cja-019033	Callithrix jacchus	87.85	0.00e+00	2800.00
IUUC-Cfa-020695	Canis familiaris	83.17	0.00e+00	1622.00
IUUC-Cpo-021513	Cavia porcellus	76.20	0.00e+00	2387.00
IUUC-Csa-023798	Chlorocebus sabaeus	92.89	0.00e+00	2928.00
IUUC-Dno-029587	Dasypus novemcinctus	77.22	0.00e+00	1390.00
IUUC-Dor-030234	Dipodomys ordii	80.62	0.00e+00	2642.00
IUUC-Ete-032612	Echinops telfairi	72.28	0.00e+00	787.00
IUUC-Eca-033408	Equus caballus	85.29	0.00e+00	2646.00
IUUC-Fca-035483	Felis catus	85.48	0.00e+00	2701.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.30	0.00e+00	1105.00
IUUC-Ggo-044721	Gorilla gorilla	94.39	0.00e+00	2939.00
IUUC-Hsa-046406	Homo sapiens	94.51	0.00e+00	2990.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	84.22	0.00e+00	2636.00
IUUC-Lch-049956	Latimeria chalumnae	43.36	0.00e+00	1028.00
IUUC-Laf-054068	Loxodonta africana	81.52	0.00e+00	2635.00
IUUC-Mcc-055464	Macaca mulatta	93.06	0.00e+00	2924.00
IUUC-Meu-056198	Macropus eugenii	54.32	0.00e+00	1242.00
IUUC-Mmr-061464	Microcebus murinus	88.18	0.00e+00	2740.00
IUUC-Mdo-062018	Monodelphis domestica	56.42	0.00e+00	1313.00
IUUC-Mmu-063413	Mus musculus	73.91	0.00e+00	2277.00
IUUC-Mpu-066146	Mustela putorius furo	84.22	0.00e+00	2583.00
IUUC-Mlu-067036	Myotis lucifugus	83.79	0.00e+00	2646.00
IUUC-Opr-070670	Ochotona princeps	74.86	0.00e+00	2352.00
IUUC-Oan-073451	Ornithorhynchus anatinus	50.22	0.00e+00	1135.00
IUUC-Ocu-074155	Oryctolagus cuniculus	81.79	0.00e+00	2568.00
IUUC-Oga-089084	Otolemur garnettii	88.16	0.00e+00	2828.00
IUUC-Oar-090029	Ovis aries	82.69	0.00e+00	2638.00
IUUC-Ptr-091282	Pan troglodytes	96.71	0.00e+00	3075.00
IUUC-Pan-091883	Papio anubis	93.23	0.00e+00	2957.00
IUUC-Pca-100519	Procavia capensis	76.03	0.00e+00	837.00
IUUC-Pva-102417	Pteropus vampyrus	82.69	0.00e+00	2130.00
IUUC-Rno-105962	Rattus norvegicus	76.36	0.00e+00	2385.00
IUUC-Sar-113750	Sorex araneus	75.62	2.00e-168	587.00
IUUC-Ssc-115899	Sus scrofa	79.20	0.00e+00	2354.00
IUUC-Tsy-118860	Tarsius syrichta	79.89	0.00e+00	1035.00
IUUC-Tbe-127660	Tupaia belangeri	84.02	0.00e+00	1430.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence