iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034300

UUCD1 version

UUC-EqC-01069

Ensembl Protein ID

ENSECAP00000021093.1

UniProt Accession

F7CEJ9; F7CEJ9_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000023344.1	ENSECAT00000025357.1	ENSECAP00000021093.1
ENSECAG00000023344.1	ENSECAT00000025389.1	ENSECAP00000021117.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-55	187.9	141	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC+  +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 141  VGLKNVGNTCW-SAVIQSLFQLPEFRRLVLSyslpqNVLENCPSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 226
           6*********9.7******************96555445555543.3678889******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +  +     +e+f +++
   Q: 227  PEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNDPRNKSENPMVQLFYGTFLTEGVREGKHF--CNNETFGQYP 295
           799********************22..................234567999***************9998765544..56999***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 296  LQVNGYR-----NLDECLEGAMVEGDIE----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 373
           *******.....99****7766666665....55544..456778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 374  RYMYRskelirskrecvqklkeevkvlqqkleryvkygsgparfplpdmlkyviefastkpasessssqsdarltlpvssvhspgsdlt 462
           *9999888888888888888888888888888888888888888888888888888877777776666666666666666666666666 PP
   S: 268  ...peekqke............................................................................... 274
              +     +                                                                               
   Q: 463  seeS-----Tskesssqdvessfsscedclhksetvnnplrasrssmemparpaprtvtdeeinfvktclqrwrseieqdiqdlkncia 546
           5540.....04455666677777777777777777778888888888888888888888888888999999999999999999999999 PP
   S: 275  ................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                           ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 547  sttqtieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQvWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 630
           99999999*******9***************************99999*******************8879************6 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

SCQMLLNQLR EITGIQDPSF LHEALKASNG DITQAVSLLT DERVKEPSQD SVATEPSEVE 60
GSAANKEVLA KVIDLTHDNK DDLQAAIALS LLESPKIQAD GRDLNRMHEA TSAETKRSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCCAAA TGCTGTTAAA TCAACTGAGA GAAATCACAG GCATCCAAGA TCCTTCCTTT 60
CTTCATGAAG CTCTCAAGGT TAGTTTCAAG GCTTCTGTTA GTCAACAGGC TTTAAAACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	94.44	0.00e+00	1998.00
IUUC-Apl-004010	Anas platyrhynchos	69.46	0.00e+00	1449.00
IUUC-Aca-004741	Anolis carolinensis	58.41	0.00e+00	833.00
IUUC-Afu-008871	Aspergillus fumigatus	34.65	1.00e-07	52.80
IUUC-Ani-009503	Aspergillus nidulans	35.85	3.00e-11	64.70
IUUC-Ang-009577	Aspergillus niger	37.37	5.00e-12	67.00
IUUC-Ate-010275	Aspergillus terreus	36.11	8.00e-12	66.20
IUUC-Bta-013377	Bos taurus	93.22	0.00e+00	1902.00
IUUC-Cel-018346	Caenorhabditis elegans	28.99	2.00e-24	108.00
IUUC-Cja-019977	Callithrix jacchus	94.26	0.00e+00	1954.00
IUUC-Cfa-020378	Canis familiaris	93.07	0.00e+00	1362.00
IUUC-Cpo-021817	Cavia porcellus	90.12	0.00e+00	1890.00
IUUC-Csa-023446	Chlorocebus sabaeus	92.98	0.00e+00	1340.00
IUUC-Cho-024717	Choloepus hoffmanni	84.06	0.00e+00	1218.00
IUUC-Cin-025302	Ciona intestinalis	35.30	5.00e-87	315.00
IUUC-Csv-025911	Ciona savignyi	34.63	2.00e-142	499.00
IUUC-Cme-027167	Cyanidioschyzon merolae	32.85	1.00e-14	75.50
IUUC-Dre-028105	Danio rerio	56.55	0.00e+00	694.00
IUUC-Dno-029559	Dasypus novemcinctus	90.21	0.00e+00	1501.00
IUUC-Dor-030955	Dipodomys ordii	90.30	0.00e+00	1892.00
IUUC-Ete-032828	Echinops telfairi	82.25	0.00e+00	1161.00
IUUC-Eeu-034458	Erinaceus europaeus	89.05	0.00e+00	1697.00
IUUC-Fca-035753	Felis catus	93.88	0.00e+00	1978.00
IUUC-Fal-037062	Ficedula albicollis	64.12	0.00e+00	865.00
IUUC-Gmo-039593	Gadus morhua	51.86	0.00e+00	1011.00
IUUC-Gga-040878	Gallus gallus	65.11	0.00e+00	1306.00
IUUC-Gac-041867	Gasterosteus aculeatus	54.44	0.00e+00	1092.00
IUUC-Ggo-045384	Gorilla gorilla	94.17	0.00e+00	1952.00
IUUC-Hsa-046277	Homo sapiens	94.35	0.00e+00	1958.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	87.57	0.00e+00	1146.00
IUUC-Lch-049692	Latimeria chalumnae	66.29	0.00e+00	1379.00
IUUC-Loc-052070	Lepisosteus oculatus	49.77	0.00e+00	1003.00
IUUC-Laf-053808	Loxodonta africana	87.49	0.00e+00	1788.00
IUUC-Mcc-055473	Macaca mulatta	92.98	0.00e+00	1340.00
IUUC-Meu-056416	Macropus eugenii	74.81	0.00e+00	1498.00
IUUC-Mga-060011	Meleagris gallopavo	67.64	0.00e+00	1388.00
IUUC-Mmr-060720	Microcebus murinus	91.97	0.00e+00	1872.00
IUUC-Mdo-061955	Monodelphis domestica	78.95	0.00e+00	1635.00
IUUC-Mmu-063870	Mus musculus	86.27	0.00e+00	1796.00
IUUC-Mpu-066454	Mustela putorius furo	92.40	0.00e+00	1315.00
IUUC-Mlu-067487	Myotis lucifugus	88.71	0.00e+00	1860.00
IUUC-Nfi-068458	Neosartorya fischeri	34.91	5.00e-11	63.90
IUUC-Nle-070044	Nomascus leucogenys	94.35	0.00e+00	1961.00
IUUC-Opr-070888	Ochotona princeps	96.74	2.00e-159	556.00
IUUC-Ont-072386	Oreochromis niloticus	55.18	0.00e+00	717.00
IUUC-Oan-073054	Ornithorhynchus anatinus	49.26	0.00e+00	962.00
IUUC-Ocu-074523	Oryctolagus cuniculus	90.88	0.00e+00	1888.00
IUUC-Ola-086393	Oryzias latipes	53.72	0.00e+00	1087.00
IUUC-Oga-088618	Otolemur garnettii	92.00	0.00e+00	1902.00
IUUC-Oar-089848	Ovis aries	84.14	0.00e+00	1790.00
IUUC-Ptr-091630	Pan troglodytes	93.60	0.00e+00	1496.00
IUUC-Pan-092311	Papio anubis	48.43	0.00e+00	996.00
IUUC-Psi-093422	Pelodiscus sinensis	65.14	0.00e+00	1371.00
IUUC-Pma-094250	Petromyzon marinus	52.65	2.00e-73	268.00
IUUC-Pfo-096466	Poecilia formosa	55.52	0.00e+00	733.00
IUUC-Pab-098337	Pongo abelii	94.35	0.00e+00	1956.00
IUUC-Pca-100901	Procavia capensis	76.84	0.00e+00	1543.00
IUUC-Pva-102226	Pteropus vampyrus	88.50	0.00e+00	1707.00
IUUC-Rno-105735	Rattus norvegicus	83.01	0.00e+00	1806.00
IUUC-Sha-107489	Sarcophilus harrisii	87.61	0.00e+00	1845.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.80	1.00e-09	59.30
IUUC-Ssc-115877	Sus scrofa	48.65	0.00e+00	966.00
IUUC-Tgu-116609	Taeniopygia guttata	68.42	0.00e+00	1389.00
IUUC-Tru-117807	Takifugu rubripes	53.94	0.00e+00	1077.00
IUUC-Tsy-118971	Tarsius syrichta	86.40	0.00e+00	1209.00
IUUC-Tni-119983	Tetraodon nigroviridis	54.80	0.00e+00	1090.00
IUUC-Ttr-128887	Tursiops truncatus	88.70	0.00e+00	1798.00
IUUC-Vpa-130614	Vicugna pacos	92.90	0.00e+00	1504.00
IUUC-Xtr-132436	Xenopus tropicalis	62.76	0.00e+00	1268.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence