iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054490

UUCD1 version

UUC-LoA-00375

Ensembl Protein ID

ENSLAFP00000009167.2

UniProt Accession

G3T6K8; G3T6K8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000010952.2	ENSLAFT00000010960.2	ENSLAFP00000009167.2
ENSLAFG00000010952.2	ENSLAFT00000033876.1	ENSLAFP00000021735.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	86.15	0.00e+00	1654.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
771	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Loxodonta africana

Protein Sequence
(Fasta)

PLTVDAVTAL PLQVAPTAVP MDLRLDPPFP LPVAEPALRE QQLQQELLAL KQKQQLQRQI 60
LIAEFQRQHE QLSRQHEAQL HEHVKQNEKL THEQTRCIHQ RNMRKGVEDR ECSRGHGEAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTCACAG TGGACGCAGT CACAGCACTG CCCCTGCAAG TCGCTCCCAC GGCTGTGCCC 60
ATGGACCTGC GCCTGGACCC ACCGTTCCCG CTGCCCGTGG CGGAGCCTGC CCTGCGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	85.74	0.00e+00	1554.00
IUUC-Apl-003250	Anas platyrhynchos	83.43	0.00e+00	1535.00
IUUC-Aca-004668	Anolis carolinensis	77.12	0.00e+00	1491.00
IUUC-Bta-013215	Bos taurus	86.62	0.00e+00	1572.00
IUUC-Cja-019816	Callithrix jacchus	85.86	0.00e+00	1605.00
IUUC-Cfa-020861	Canis familiaris	85.74	0.00e+00	1543.00
IUUC-Cpo-021562	Cavia porcellus	85.07	0.00e+00	1583.00
IUUC-Csa-023612	Chlorocebus sabaeus	85.17	0.00e+00	1565.00
IUUC-Csv-026359	Ciona savignyi	55.41	3.00e-94	337.00
IUUC-Dre-028284	Danio rerio	87.55	0.00e+00	868.00
IUUC-Dno-029951	Dasypus novemcinctus	83.62	0.00e+00	1468.00
IUUC-Dor-030362	Dipodomys ordii	76.03	0.00e+00	1325.00
IUUC-Dme-031766	Drosophila melanogaster	59.10	2.00e-159	556.00
IUUC-Fca-036187	Felis catus	86.84	0.00e+00	1589.00
IUUC-Gmo-038473	Gadus morhua	77.09	0.00e+00	742.00
IUUC-Gga-040501	Gallus gallus	84.05	0.00e+00	1536.00
IUUC-Gac-042335	Gasterosteus aculeatus	84.98	0.00e+00	848.00
IUUC-Ggo-045380	Gorilla gorilla	85.67	0.00e+00	1573.00
IUUC-Hsa-046925	Homo sapiens	86.15	0.00e+00	1597.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	86.41	0.00e+00	1568.00
IUUC-Lch-050325	Latimeria chalumnae	77.50	0.00e+00	1414.00
IUUC-Loc-052231	Lepisosteus oculatus	75.52	0.00e+00	1363.00
IUUC-Mcc-055265	Macaca mulatta	85.50	0.00e+00	1580.00
IUUC-Meu-056676	Macropus eugenii	84.92	0.00e+00	726.00
IUUC-Mmr-061633	Microcebus murinus	85.53	0.00e+00	1131.00
IUUC-Mmu-063089	Mus musculus	86.22	0.00e+00	1543.00
IUUC-Mpu-065887	Mustela putorius furo	85.86	0.00e+00	1564.00
IUUC-Mlu-067470	Myotis lucifugus	86.28	0.00e+00	1609.00
IUUC-Nle-069099	Nomascus leucogenys	80.33	0.00e+00	994.00
IUUC-Ont-071613	Oreochromis niloticus	68.97	0.00e+00	1204.00
IUUC-Oan-073275	Ornithorhynchus anatinus	84.28	0.00e+00	1566.00
IUUC-Ola-087031	Oryzias latipes	64.86	0.00e+00	1136.00
IUUC-Oga-088201	Otolemur garnettii	79.30	0.00e+00	1410.00
IUUC-Oar-089997	Ovis aries	83.01	0.00e+00	1380.00
IUUC-Ptr-091116	Pan troglodytes	85.96	0.00e+00	1612.00
IUUC-Pan-092132	Papio anubis	87.10	0.00e+00	1103.00
IUUC-Psi-093734	Pelodiscus sinensis	83.52	0.00e+00	1474.00
IUUC-Pma-094347	Petromyzon marinus	69.38	0.00e+00	697.00
IUUC-Pfo-096293	Poecilia formosa	66.77	0.00e+00	1168.00
IUUC-Pab-098491	Pongo abelii	82.90	0.00e+00	1514.00
IUUC-Pca-101004	Procavia capensis	82.80	0.00e+00	912.00
IUUC-Pva-102961	Pteropus vampyrus	68.58	0.00e+00	842.00
IUUC-Rno-105005	Rattus norvegicus	86.35	0.00e+00	1516.00
IUUC-Sha-107646	Sarcophilus harrisii	64.71	0.00e+00	948.00
IUUC-Ssc-115428	Sus scrofa	86.16	0.00e+00	1549.00
IUUC-Tgu-116776	Taeniopygia guttata	83.10	0.00e+00	1506.00
IUUC-Tru-118180	Takifugu rubripes	66.06	0.00e+00	1196.00
IUUC-Tsy-119468	Tarsius syrichta	80.92	0.00e+00	729.00
IUUC-Tni-120196	Tetraodon nigroviridis	67.10	0.00e+00	1184.00
IUUC-Ttr-128360	Tursiops truncatus	80.62	0.00e+00	964.00
IUUC-Xtr-132956	Xenopus tropicalis	74.95	0.00e+00	1343.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence