iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054228

Ensembl Protein ID

ENSLAFP00000008618.2

UniProt Accession

G3T5B4; G3T5B4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000010291.2	ENSLAFT00000010289.2	ENSLAFP00000008618.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-44	149.9	196	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ l+
   Q: 196  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGQIGLVPKNYVVVLS 255
           689**************************************.7**************9886 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANKTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP ANGSSADRIY DLNIPAYVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAGAAG AAGTGATTGT TATAGCAAAG TGGGATTACA CTGCCCAACA GGATCAGGAA 60
CTTGACATCA AGAAGAATGA GCGCCTGTGG CTGCTGGATG ACTCCAAGAC ATGGTGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

lav:100660400

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	95.26	0.00e+00	738.00
IUUC-Apl-003456	Anas platyrhynchos	95.26	0.00e+00	735.00
IUUC-Aca-005105	Anolis carolinensis	93.95	0.00e+00	726.00
IUUC-Ame-010966	Astyanax mexicanus	78.85	3.00e-177	613.00
IUUC-Bta-012424	Bos taurus	86.84	0.00e+00	638.00
IUUC-Cel-018144	Caenorhabditis elegans	41.91	9.00e-77	280.00
IUUC-Cja-019898	Callithrix jacchus	95.00	0.00e+00	738.00
IUUC-Cfa-020830	Canis familiaris	94.21	0.00e+00	732.00
IUUC-Cpo-021487	Cavia porcellus	84.75	0.00e+00	647.00
IUUC-Csa-023693	Chlorocebus sabaeus	95.53	0.00e+00	742.00
IUUC-Cin-025348	Ciona intestinalis	39.25	6.00e-68	251.00
IUUC-Dre-028334	Danio rerio	81.94	0.00e+00	625.00
IUUC-Dno-028973	Dasypus novemcinctus	96.84	0.00e+00	743.00
IUUC-Dor-031003	Dipodomys ordii	93.68	0.00e+00	696.00
IUUC-Ete-032792	Echinops telfairi	87.76	0.00e+00	669.00
IUUC-Eca-033656	Equus caballus	95.53	0.00e+00	739.00
IUUC-Fca-036347	Felis catus	95.53	0.00e+00	739.00
IUUC-Fal-037095	Ficedula albicollis	95.00	0.00e+00	736.00
IUUC-Gmo-039410	Gadus morhua	69.35	6.00e-160	556.00
IUUC-Gga-040155	Gallus gallus	95.26	0.00e+00	735.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.92	5.00e-167	580.00
IUUC-Ggo-044805	Gorilla gorilla	95.26	0.00e+00	739.00
IUUC-Hsa-046585	Homo sapiens	95.26	0.00e+00	739.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	93.16	0.00e+00	707.00
IUUC-Lch-049795	Latimeria chalumnae	89.74	0.00e+00	698.00
IUUC-Loc-051985	Lepisosteus oculatus	90.00	0.00e+00	673.00
IUUC-Mcc-055402	Macaca mulatta	95.53	0.00e+00	742.00
IUUC-Mga-059374	Meleagris gallopavo	95.26	0.00e+00	735.00
IUUC-Mmr-061453	Microcebus murinus	94.74	0.00e+00	736.00
IUUC-Mdo-063080	Monodelphis domestica	93.95	0.00e+00	729.00
IUUC-Mmu-063529	Mus musculus	92.89	0.00e+00	710.00
IUUC-Mpu-066815	Mustela putorius furo	95.26	0.00e+00	738.00
IUUC-Mlu-067132	Myotis lucifugus	91.80	2.00e-161	560.00
IUUC-Nle-069371	Nomascus leucogenys	95.26	0.00e+00	739.00
IUUC-Opr-070948	Ochotona princeps	93.90	0.00e+00	692.00
IUUC-Ont-071410	Oreochromis niloticus	75.19	2.00e-165	575.00
IUUC-Oan-073304	Ornithorhynchus anatinus	93.46	3.00e-166	577.00
IUUC-Ocu-074783	Oryctolagus cuniculus	93.95	0.00e+00	711.00
IUUC-Ola-086808	Oryzias latipes	74.04	4.00e-162	563.00
IUUC-Oga-088391	Otolemur garnettii	95.00	0.00e+00	720.00
IUUC-Oar-090025	Ovis aries	81.00	6.00e-167	579.00
IUUC-Ptr-090975	Pan troglodytes	95.26	0.00e+00	739.00
IUUC-Pan-092287	Papio anubis	95.53	0.00e+00	742.00
IUUC-Psi-093413	Pelodiscus sinensis	95.79	0.00e+00	738.00
IUUC-Pfo-097129	Poecilia formosa	77.10	7.00e-171	593.00
IUUC-Pab-098756	Pongo abelii	95.26	0.00e+00	739.00
IUUC-Pca-100235	Procavia capensis	85.00	0.00e+00	657.00
IUUC-Pva-102294	Pteropus vampyrus	91.58	0.00e+00	702.00
IUUC-Rno-105090	Rattus norvegicus	92.89	0.00e+00	710.00
IUUC-Sha-107521	Sarcophilus harrisii	94.47	0.00e+00	733.00
IUUC-Sar-113697	Sorex araneus	86.72	0.00e+00	656.00
IUUC-Ssc-115958	Sus scrofa	85.76	1.00e-163	568.00
IUUC-Tgu-116559	Taeniopygia guttata	93.16	0.00e+00	710.00
IUUC-Tru-117677	Takifugu rubripes	76.20	3.00e-168	584.00
IUUC-Tni-120434	Tetraodon nigroviridis	77.00	2.00e-165	575.00
IUUC-Tbe-127931	Tupaia belangeri	93.67	9.00e-180	622.00
IUUC-Ttr-128993	Tursiops truncatus	86.84	0.00e+00	642.00
IUUC-Xtr-132543	Xenopus tropicalis	85.83	0.00e+00	675.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence