iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-025993

UUCD1 version

UUC-CiS-00374

Ensembl Protein ID

ENSCSAVP00000014988.1

UniProt Accession

H2ZBM3; H2ZBM3_CIOSA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000008776.1	ENSCSAVT00000015162.1	ENSCSAVP00000014988.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-105	353.5	550	870

Active Site

Position(s)	Description	Evidence
844	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +++lk +++v+f++Eeg+++ Gv re+++ ls+e+ np++glf+ s  d +++qpn+ s + np+hl++Fef+G++l +al++++l++
   Q: 550  AENLKGNFMVQFTNEEGMGN-GVLREWFSVLSNEILNPEYGLFVPSF-DGCSFQPNSRSSI-NPDHLSYFEFAGKILSVALYHKHLIN 634
           578999**************.**********************7665.88999******99.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           + l++sfyk+llg+k+s+ed+e++dpe++ +l++i++n   di+++gl+l+f+v+++++g ++e eL pgG++ +Vt+eNk+eYv+lv
   Q: 635  ASLTSSFYKHLLGRKISYEDVESIDPEYATNLQWILDN---DISDIGLNLNFTVETDVFGRMEEIELTPGGSRLSVTEENKQEYVQLV 719
           ************************************99...*********************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           +e+++++ i++q+++f +Gfn++ip  l+++Ft+ee++l++ G++eidve +k+ t+y g y++++++iqwFwe++e++++++r+ +L
   Q: 720  TELKMTSAIQRQLDSFIRGFNSIIPSYLIRIFTPEEMDLMLTGCREIDVEIWKSITEYSGCYNPTHQVIQWFWECVERMQNDDRSLLL 807
           **************************************************************************************** PP
   S: 266  qFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet 330
           +F Tg+srlP+   + +  ++f+i      d lPs++TC+++LkLPeY+s+e+l+ kLl+Ai+ +
   Q: 808  HFSTGRSRLPA--PNVIFSNKFMITSIPPSDLLPSASTCMSLLKLPEYDSYETLETKLLTAIRCG 870
           **********8..45555668999999999********************************985 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MWSPKHQLMR LSRSLRIGRS VELPRDPASA IHILLPMVFG NQHKSLSELL ENSPFDVNHP 60
IGRSNRTLLH IAANCGQLEC VACLLKHGAD PNAIDIAGCC AIHLASKNGK KRCMEKLLEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAGTC CAAAGCACCA ATTGATGCGT TTAAGTCGAT CGCTAAGAAT CGGCCGTTCA 60
GTTGAATTGC CTCGTGACCC AGCGTCTGCC ATTCACATCC TCCTACCAAT GGTGTTCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF00023--Ank
PF12796--Ank_2
PF00632--HECT

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	43.76	0.00e+00	747.00
IUUC-Apl-003400	Anas platyrhynchos	45.21	4.00e-139	486.00
IUUC-Aca-005375	Anolis carolinensis	43.88	0.00e+00	753.00
IUUC-Ame-011847	Astyanax mexicanus	47.08	4.00e-144	503.00
IUUC-Bta-012831	Bos taurus	43.24	0.00e+00	735.00
IUUC-Cja-019160	Callithrix jacchus	43.77	0.00e+00	755.00
IUUC-Cfa-020346	Canis familiaris	44.00	0.00e+00	755.00
IUUC-Cpo-021766	Cavia porcellus	43.42	0.00e+00	758.00
IUUC-Csa-023768	Chlorocebus sabaeus	44.55	0.00e+00	758.00
IUUC-Cho-024688	Choloepus hoffmanni	43.59	8.00e-130	456.00
IUUC-Cin-025417	Ciona intestinalis	75.88	0.00e+00	730.00
IUUC-Dre-027819	Danio rerio	45.35	0.00e+00	776.00
IUUC-Dno-029027	Dasypus novemcinctus	44.37	0.00e+00	749.00
IUUC-Dor-030327	Dipodomys ordii	39.80	4.00e-180	623.00
IUUC-Ete-032966	Echinops telfairi	40.46	0.00e+00	668.00
IUUC-Eca-034339	Equus caballus	43.58	0.00e+00	753.00
IUUC-Eeu-034544	Erinaceus europaeus	46.06	2.00e-73	269.00
IUUC-Fca-035617	Felis catus	44.72	2.00e-136	478.00
IUUC-Fal-036687	Ficedula albicollis	45.03	7.00e-140	489.00
IUUC-Gmo-039508	Gadus morhua	51.83	6.00e-133	466.00
IUUC-Gga-040845	Gallus gallus	45.21	3.00e-140	491.00
IUUC-Gac-041894	Gasterosteus aculeatus	43.14	0.00e+00	741.00
IUUC-Ggo-044465	Gorilla gorilla	42.55	0.00e+00	715.00
IUUC-Hsa-045731	Homo sapiens	44.15	0.00e+00	759.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	44.55	0.00e+00	761.00
IUUC-Lch-050436	Latimeria chalumnae	44.21	0.00e+00	775.00
IUUC-Loc-052287	Lepisosteus oculatus	46.40	2.00e-145	508.00
IUUC-Laf-053846	Loxodonta africana	43.73	0.00e+00	756.00
IUUC-Mcc-055845	Macaca mulatta	44.55	0.00e+00	759.00
IUUC-Meu-056060	Macropus eugenii	40.88	4.00e-70	258.00
IUUC-Mga-059935	Meleagris gallopavo	43.49	0.00e+00	756.00
IUUC-Mmr-060960	Microcebus murinus	43.71	0.00e+00	758.00
IUUC-Mdo-061851	Monodelphis domestica	45.14	6.00e-137	479.00
IUUC-Mmu-063657	Mus musculus	43.80	0.00e+00	753.00
IUUC-Mpu-066161	Mustela putorius furo	52.01	1.00e-118	417.00
IUUC-Mlu-067354	Myotis lucifugus	42.98	0.00e+00	713.00
IUUC-Nle-069112	Nomascus leucogenys	44.66	0.00e+00	761.00
IUUC-Opr-070686	Ochotona princeps	45.89	7.00e-111	393.00
IUUC-Ont-072398	Oreochromis niloticus	43.74	0.00e+00	743.00
IUUC-Oan-073194	Ornithorhynchus anatinus	43.69	0.00e+00	728.00
IUUC-Ocu-074397	Oryctolagus cuniculus	50.97	2.00e-118	418.00
IUUC-Ola-086777	Oryzias latipes	50.75	3.00e-139	487.00
IUUC-Oga-088684	Otolemur garnettii	43.81	0.00e+00	751.00
IUUC-Oar-089428	Ovis aries	43.35	0.00e+00	737.00
IUUC-Ptr-090529	Pan troglodytes	44.04	0.00e+00	758.00
IUUC-Pan-091702	Papio anubis	44.55	0.00e+00	759.00
IUUC-Psi-093969	Pelodiscus sinensis	44.77	5.00e-138	483.00
IUUC-Pfo-097364	Poecilia formosa	44.87	0.00e+00	757.00
IUUC-Pab-098574	Pongo abelii	44.15	0.00e+00	759.00
IUUC-Pca-100525	Procavia capensis	45.59	2.00e-76	278.00
IUUC-Pva-102365	Pteropus vampyrus	39.07	2.00e-180	624.00
IUUC-Rno-105153	Rattus norvegicus	43.82	0.00e+00	758.00
IUUC-Sha-107319	Sarcophilus harrisii	45.42	9.00e-137	479.00
IUUC-Stu-112011	Solanum tuberosum	34.09	7.00e-54	203.00
IUUC-Ssc-115865	Sus scrofa	43.60	0.00e+00	753.00
IUUC-Tgu-117225	Taeniopygia guttata	45.03	9.00e-140	489.00
IUUC-Tru-118026	Takifugu rubripes	45.99	2.00e-140	491.00
IUUC-Tsy-119407	Tarsius syrichta	37.53	6.00e-170	589.00
IUUC-Tni-120234	Tetraodon nigroviridis	43.61	1.00e-168	584.00
IUUC-Tur-126774	Triticum urartu	30.70	2.00e-47	182.00
IUUC-Tbe-127708	Tupaia belangeri	32.99	3.00e-68	251.00
IUUC-Ttr-128667	Tursiops truncatus	43.49	0.00e+00	753.00
IUUC-Vpa-130200	Vicugna pacos	42.76	0.00e+00	718.00
IUUC-Xtr-132176	Xenopus tropicalis	45.47	2.00e-139	488.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence