iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053581

UUCD1 version

UUC-LoA-00200

Ensembl Protein ID

ENSLAFP00000004767.3

UniProt Accession

G3SWP9; G3SWP9_LOXAF

Protein Name

Uncharacterized protein

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005684.3	ENSLAFT00000005683.3	ENSLAFP00000004767.3
ENSLAFG00000005684.3	ENSLAFT00000030771.1	ENSLAFP00000027659.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-40	137.7	389	696

Active Site

Position(s)	Description	Evidence
666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
            lev + +E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++s
   Q: 389  ALEVAYINENdkfGREHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFFS 468
           5889999999889***********************..45..677788888888885.....689************************ PP
   S: 94   ksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           k+++++l   +   e ++ + +++ ++ + +i  + ++ ++    dl     +++++e++++  ++g+ +   t ++k+  v++++ y+
   Q: 469  KTLFNCLAYGP---EKTQPILDDVSDFdVAQIIIRINTATNMD--DL-----NSVINECYNYLKLTGCLKLIRTLSDKYHLVNDILFYH 547
           **********8...89999999999998888776643222222..33.....345788999977778899999**************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq... 266
           + ++++  +e+f++G++++  le+++ + e  +++l+++ e+++++ l++   +  ++ +d +++  Fw+++ + ++  + ++ ++   
   Q: 548  VIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFCSILCHKPETLSAKVLSD--LFAVHTLSDVQTL-GFWNTYlQTIEGGKSATTMEdil 633
           ************************************************99..7888889999997.99998767777777766666666 PP
   S: 267  .FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            F+Tg+s++P+ Gf++ + ++ +++      ++P  n+C n+L LP  +++++++e++ +Ai++t ++e
   Q: 634  iFATGCSSIPPTGFKPTP-SIECLHM-----DFPIGNKCNNCLALPITNTYKEFQENMDFAIRNTLRLE 696
           6****************9.9999999.....********************************987665 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MKKCHIDVLE VLACVFCRKN DDSPNKYGEK KTNEKWKLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CCICKRNGAS IGCVAPRCKR SYHYPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAAAAT GTCACATTGA TGTTTTAGAA GTAGATATTT TTAAATTTTA AAATTACTCA 60
TAGTAGTATA ATATGATTTG CTCTCTCTGA AAGAAGTTAC ACATCAATTA AAAGAAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	88.29	0.00e+00	1305.00
IUUC-Apl-003763	Anas platyrhynchos	59.03	0.00e+00	838.00
IUUC-Aca-004328	Anolis carolinensis	59.23	0.00e+00	848.00
IUUC-Ame-011288	Astyanax mexicanus	39.91	4.00e-157	548.00
IUUC-Bta-012496	Bos taurus	84.37	0.00e+00	1246.00
IUUC-Cja-019756	Callithrix jacchus	86.85	0.00e+00	1276.00
IUUC-Cfa-020806	Canis familiaris	87.72	0.00e+00	1292.00
IUUC-Cpo-022519	Cavia porcellus	83.88	0.00e+00	1217.00
IUUC-Csa-023957	Chlorocebus sabaeus	88.29	0.00e+00	1301.00
IUUC-Cho-024375	Choloepus hoffmanni	83.07	0.00e+00	1176.00
IUUC-Cin-025325	Ciona intestinalis	40.99	1.00e-62	233.00
IUUC-Csv-026262	Ciona savignyi	42.31	6.00e-66	244.00
IUUC-Dre-027829	Danio rerio	40.31	8.00e-152	530.00
IUUC-Dno-029362	Dasypus novemcinctus	89.19	0.00e+00	1289.00
IUUC-Dor-030710	Dipodomys ordii	81.87	0.00e+00	1207.00
IUUC-Dme-031692	Drosophila melanogaster	34.07	3.00e-41	163.00
IUUC-Ete-032282	Echinops telfairi	82.40	0.00e+00	1172.00
IUUC-Eca-033963	Equus caballus	87.63	0.00e+00	1305.00
IUUC-Eeu-035029	Erinaceus europaeus	84.10	0.00e+00	1242.00
IUUC-Fca-036229	Felis catus	87.72	0.00e+00	1300.00
IUUC-Fal-037015	Ficedula albicollis	56.36	0.00e+00	835.00
IUUC-Gmo-039715	Gadus morhua	39.62	1.00e-78	286.00
IUUC-Gga-040298	Gallus gallus	57.10	0.00e+00	864.00
IUUC-Gac-041444	Gasterosteus aculeatus	37.65	2.00e-137	482.00
IUUC-Ggo-045456	Gorilla gorilla	88.15	0.00e+00	1297.00
IUUC-Hsa-046297	Homo sapiens	88.44	0.00e+00	1306.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.28	0.00e+00	919.00
IUUC-Lch-050287	Latimeria chalumnae	65.88	2.00e-104	373.00
IUUC-Loc-052839	Lepisosteus oculatus	58.42	4.00e-32	129.00
IUUC-Mcc-055615	Macaca mulatta	88.29	0.00e+00	1302.00
IUUC-Meu-056753	Macropus eugenii	48.27	7.00e-128	451.00
IUUC-Mga-059902	Meleagris gallopavo	56.93	0.00e+00	869.00
IUUC-Mmr-061522	Microcebus murinus	89.35	0.00e+00	1312.00
IUUC-Mdo-063022	Monodelphis domestica	64.19	0.00e+00	881.00
IUUC-Mmu-063609	Mus musculus	75.72	0.00e+00	1155.00
IUUC-Mpu-066656	Mustela putorius furo	87.14	0.00e+00	1296.00
IUUC-Mlu-067011	Myotis lucifugus	86.69	0.00e+00	1273.00
IUUC-Nle-069949	Nomascus leucogenys	88.01	0.00e+00	1298.00
IUUC-Opr-071224	Ochotona princeps	83.83	1.00e-131	463.00
IUUC-Ont-072174	Oreochromis niloticus	37.07	3.00e-136	479.00
IUUC-Oan-072712	Ornithorhynchus anatinus	68.10	0.00e+00	980.00
IUUC-Ocu-073776	Oryctolagus cuniculus	88.01	0.00e+00	1282.00
IUUC-Ola-087247	Oryzias latipes	36.04	5.00e-126	444.00
IUUC-Oga-088094	Otolemur garnettii	85.91	0.00e+00	1210.00
IUUC-Oar-090248	Ovis aries	83.94	0.00e+00	1238.00
IUUC-Ptr-090634	Pan troglodytes	88.29	0.00e+00	1303.00
IUUC-Pan-092876	Papio anubis	88.44	0.00e+00	1303.00
IUUC-Psi-093580	Pelodiscus sinensis	60.83	0.00e+00	875.00
IUUC-Pma-094295	Petromyzon marinus	53.75	7.00e-73	266.00
IUUC-Pfo-096351	Poecilia formosa	38.18	5.00e-141	494.00
IUUC-Pab-097596	Pongo abelii	88.87	0.00e+00	1308.00
IUUC-Pca-100309	Procavia capensis	88.14	0.00e+00	1285.00
IUUC-Pva-102526	Pteropus vampyrus	90.18	0.00e+00	843.00
IUUC-Rno-105432	Rattus norvegicus	79.94	0.00e+00	1194.00
IUUC-Sha-107089	Sarcophilus harrisii	65.26	0.00e+00	1001.00
IUUC-Sar-113667	Sorex araneus	66.54	0.00e+00	739.00
IUUC-Ssc-116200	Sus scrofa	87.16	0.00e+00	1285.00
IUUC-Tgu-116467	Taeniopygia guttata	55.91	0.00e+00	823.00
IUUC-Tru-117690	Takifugu rubripes	38.84	7.00e-151	527.00
IUUC-Tsy-119481	Tarsius syrichta	84.62	0.00e+00	877.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.81	4.00e-129	455.00
IUUC-Tbe-127241	Tupaia belangeri	82.51	0.00e+00	1127.00
IUUC-Ttr-129057	Tursiops truncatus	78.87	0.00e+00	1107.00
IUUC-Vpa-130685	Vicugna pacos	84.87	0.00e+00	1228.00
IUUC-Xtr-132555	Xenopus tropicalis	53.51	0.00e+00	730.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence