iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035247.15	ENSMUST00000179265.7	ENSMUSP00000136449.1
ENSMUSG00000035247.15	ENSMUST00000042052.8	ENSMUSP00000046766.8

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-120	404.0	2157	2618

Active Site

Position(s)	Description	Evidence
2587	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg +l+++n  d+e+++++   glk+p                     
   Q: 2157 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGTWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2242
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2243 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2329
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2330 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilgnkslsedekntklqelvlrnpsgsgpplSIEDLGLN 2416
           7777777777766666668***********************9334455555667777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr...eGfneviplellslFteeelellicGee 222
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr   +Gfn+v+p+e+ls+F++ee+++++cG+ 
   Q: 2417 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRgnvDGFNKVFPMEKLSSFSHEEVQMILCGN- 2501
           *************999.**************************************97778**************************. PP
   S: 223  eidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnT 303
             +++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nT
   Q: 2502 --QSPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNT 2586
           ..6666666665555555********************************************************************* PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFels 336
           C++yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2587 CVHYLKLPEYSSEEIMRERLLAATME-KGFHLN 2618
           **************************.****86 PP

Organism

Mus musculus

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure.

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTGCCCCC GCCCGGCTGG CGATGGACGC GGCGTCTCCC CGCTGCCGCC GACGGCCCCG 60
CGCGGACCTG GCTCTGAACC GCAGGGTCTG AGGAGCCGCG TGCTGGGGTC GGGACCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0035904--P:aorta development
GO:0001892--P:embryonic placenta development
GO:0003170--P:heart valve development
GO:0001779--P:natural killer cell differentiation
GO:1903077--P:negative regulation of protein localization to plasma membrane
GO:0001843--P:neural tube closure
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	98.20	0.00e+00	4609.00
IUUC-Apl-003493	Anas platyrhynchos	94.74	0.00e+00	4465.00
IUUC-Aca-004521	Anolis carolinensis	95.53	0.00e+00	2766.00
IUUC-Ame-011258	Astyanax mexicanus	90.26	0.00e+00	2347.00
IUUC-Bta-012835	Bos taurus	98.09	0.00e+00	4617.00
IUUC-Cel-018153	Caenorhabditis elegans	52.47	2.00e-168	588.00
IUUC-Cja-019174	Callithrix jacchus	97.44	0.00e+00	4567.00
IUUC-Cfa-021115	Canis familiaris	97.94	0.00e+00	4558.00
IUUC-Cpo-022382	Cavia porcellus	94.37	0.00e+00	4396.00
IUUC-Csa-023230	Chlorocebus sabaeus	98.32	0.00e+00	4615.00
IUUC-Cho-024711	Choloepus hoffmanni	95.47	0.00e+00	1637.00
IUUC-Cin-025342	Ciona intestinalis	52.98	0.00e+00	1371.00
IUUC-Csv-026031	Ciona savignyi	51.72	0.00e+00	1407.00
IUUC-Dre-027435	Danio rerio	86.88	0.00e+00	4089.00
IUUC-Dno-029954	Dasypus novemcinctus	97.98	0.00e+00	4576.00
IUUC-Dor-030734	Dipodomys ordii	96.89	0.00e+00	1483.00
IUUC-Dme-031739	Drosophila melanogaster	59.54	0.00e+00	1629.00
IUUC-Ete-033192	Echinops telfairi	97.92	0.00e+00	701.00
IUUC-Eca-033434	Equus caballus	98.05	0.00e+00	4608.00
IUUC-Eeu-035031	Erinaceus europaeus	83.38	2.00e-169	589.00
IUUC-Fca-035998	Felis catus	96.49	0.00e+00	4494.00
IUUC-Fal-037468	Ficedula albicollis	94.27	0.00e+00	2765.00
IUUC-Gmo-038495	Gadus morhua	90.72	0.00e+00	1362.00
IUUC-Gga-040736	Gallus gallus	96.19	0.00e+00	2775.00
IUUC-Gac-041777	Gasterosteus aculeatus	90.81	0.00e+00	2387.00
IUUC-Ggo-044677	Gorilla gorilla	94.21	0.00e+00	4364.00
IUUC-Hsa-045879	Homo sapiens	98.32	0.00e+00	4615.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	98.20	0.00e+00	4616.00
IUUC-Lch-050444	Latimeria chalumnae	91.04	0.00e+00	4149.00
IUUC-Loc-051986	Lepisosteus oculatus	87.68	0.00e+00	4125.00
IUUC-Laf-054230	Loxodonta africana	98.17	0.00e+00	4580.00
IUUC-Mcc-054787	Macaca mulatta	98.32	0.00e+00	4615.00
IUUC-Meu-056502	Macropus eugenii	89.20	0.00e+00	1335.00
IUUC-Mga-059409	Meleagris gallopavo	90.43	0.00e+00	2061.00
IUUC-Mmr-061667	Microcebus murinus	97.94	0.00e+00	4593.00
IUUC-Mdo-061960	Monodelphis domestica	96.79	0.00e+00	4565.00
IUUC-Mpu-065939	Mustela putorius furo	98.09	0.00e+00	4608.00
IUUC-Mlu-068112	Myotis lucifugus	97.78	0.00e+00	4566.00
IUUC-Nle-069001	Nomascus leucogenys	98.24	0.00e+00	4614.00
IUUC-Opr-071222	Ochotona princeps	93.57	0.00e+00	2088.00
IUUC-Ont-072101	Oreochromis niloticus	91.97	0.00e+00	2447.00
IUUC-Oan-072814	Ornithorhynchus anatinus	96.45	0.00e+00	4518.00
IUUC-Ocu-074011	Oryctolagus cuniculus	98.20	0.00e+00	4610.00
IUUC-Ola-086412	Oryzias latipes	90.44	0.00e+00	2373.00
IUUC-Oar-089668	Ovis aries	98.13	0.00e+00	4611.00
IUUC-Ptr-090517	Pan troglodytes	98.20	0.00e+00	4600.00
IUUC-Pan-091849	Papio anubis	95.61	0.00e+00	4437.00
IUUC-Psi-093390	Pelodiscus sinensis	93.03	0.00e+00	2678.00
IUUC-Pma-094628	Petromyzon marinus	82.60	0.00e+00	1564.00
IUUC-Pfo-097075	Poecilia formosa	91.20	0.00e+00	2415.00
IUUC-Pab-098176	Pongo abelii	98.32	0.00e+00	4615.00
IUUC-Pca-101123	Procavia capensis	93.00	0.00e+00	2460.00
IUUC-Pva-103008	Pteropus vampyrus	93.61	0.00e+00	1897.00
IUUC-Rno-105885	Rattus norvegicus	98.74	0.00e+00	4632.00
IUUC-Sha-107048	Sarcophilus harrisii	95.43	0.00e+00	4492.00
IUUC-Sar-113071	Sorex araneus	93.19	0.00e+00	1264.00
IUUC-Ssc-115963	Sus scrofa	97.78	0.00e+00	4589.00
IUUC-Tgu-117167	Taeniopygia guttata	92.98	0.00e+00	2601.00
IUUC-Tru-118626	Takifugu rubripes	92.17	0.00e+00	2467.00
IUUC-Tsy-119504	Tarsius syrichta	95.58	0.00e+00	2280.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.34	0.00e+00	2407.00
IUUC-Tbe-127602	Tupaia belangeri	88.89	0.00e+00	1014.00
IUUC-Ttr-128394	Tursiops truncatus	97.48	0.00e+00	3116.00
IUUC-Vpa-130280	Vicugna pacos	97.47	0.00e+00	4402.00
IUUC-Xtr-131787	Xenopus tropicalis	85.61	0.00e+00	2559.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence