iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037267

Ensembl Protein ID

ENSFALP00000013631.1

UniProt Accession

U3KF27; U3KF27_FICAL

Genbank Protein ID

ENSFALP00000013631

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01021707

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000013058.1	ENSFALT00000013687.1	ENSFALP00000013631.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-61	200.6	505	538
UBD/Beta-Prp	1.30e-102	342.7	256	538

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 505  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 538
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 256  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 340
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 341  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 423
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 424  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 509  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 538
           *************************98776 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSKPGKTAIN HGLVPVDLKS AKEPLPHQTV MKIFSISLIA QGLPFCHRRM KRKLDHGSEV 60
RSFSLGKKPC KVSEYTSTTG LVPCSATPTT FGDLRAANGQ GQQRRRITSV QPPSGLQEWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGTGAAAG CATTTGCATC TTCAGATAGC CTAGCCAAAG TCCAAGAAGT AGCAAGCTGG 60
CTTTTGGAAA TGAATCAGGA ACTGCTCTCT GTGGGCAGCA AGAGGCGACG AACTGGTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001480--Bulb-type_lectin_dom
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	98.36	0.00e+00	1094.00
IUUC-Apl-003489	Anas platyrhynchos	97.83	0.00e+00	1097.00
IUUC-Aca-005318	Anolis carolinensis	97.62	0.00e+00	1088.00
IUUC-Ago-007794	Ashbya gossypii	31.28	5.00e-61	228.00
IUUC-Acl-008123	Aspergillus clavatus	32.40	4.00e-75	275.00
IUUC-Ang-009529	Aspergillus niger	34.03	4.00e-74	273.00
IUUC-Aor-010182	Aspergillus oryzae	38.11	2.00e-71	263.00
IUUC-Ame-010898	Astyanax mexicanus	93.31	0.00e+00	1078.00
IUUC-Bta-012391	Bos taurus	98.35	0.00e+00	1091.00
IUUC-Cel-018495	Caenorhabditis elegans	48.53	4.00e-130	457.00
IUUC-Cja-018902	Callithrix jacchus	98.36	0.00e+00	1094.00
IUUC-Cfa-020237	Canis familiaris	98.36	0.00e+00	1095.00
IUUC-Cpo-022234	Cavia porcellus	98.35	0.00e+00	1093.00
IUUC-Csa-023532	Chlorocebus sabaeus	98.36	0.00e+00	1095.00
IUUC-Cho-025026	Choloepus hoffmanni	81.70	0.00e+00	726.00
IUUC-Cin-025516	Ciona intestinalis	70.99	4.00e-141	493.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	754.00
IUUC-Cne-027018	Cryptococcus neoformans	32.89	5.00e-73	269.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	1.00e-30	127.00
IUUC-Dre-028303	Danio rerio	93.72	0.00e+00	1038.00
IUUC-Dno-029576	Dasypus novemcinctus	96.35	0.00e+00	1076.00
IUUC-Dor-030196	Dipodomys ordii	96.90	0.00e+00	1071.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	6.00e-70	258.00
IUUC-Ete-032791	Echinops telfairi	90.56	0.00e+00	995.00
IUUC-Eca-033424	Equus caballus	98.35	0.00e+00	1092.00
IUUC-Eeu-034996	Erinaceus europaeus	94.89	0.00e+00	1054.00
IUUC-Fca-036422	Felis catus	98.36	0.00e+00	1097.00
IUUC-Gmo-039119	Gadus morhua	81.21	0.00e+00	894.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.46	2.00e-84	306.00
IUUC-Gga-040667	Gallus gallus	98.19	0.00e+00	1099.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.63	0.00e+00	801.00
IUUC-Ggo-044422	Gorilla gorilla	98.36	0.00e+00	1095.00
IUUC-Hsa-045898	Homo sapiens	98.36	0.00e+00	1095.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.36	0.00e+00	962.00
IUUC-Lch-050414	Latimeria chalumnae	97.60	0.00e+00	1078.00
IUUC-Loc-052348	Lepisosteus oculatus	95.61	0.00e+00	1061.00
IUUC-Laf-054054	Loxodonta africana	98.18	0.00e+00	1095.00
IUUC-Mcc-055056	Macaca mulatta	98.36	0.00e+00	1095.00
IUUC-Meu-056778	Macropus eugenii	97.72	4.00e-178	617.00
IUUC-Mor-057133	Magnaporthe oryzae	39.64	3.00e-73	270.00
IUUC-Mla-059081	Melampsora laricipopulina	32.38	4.00e-76	278.00
IUUC-Mga-059255	Meleagris gallopavo	98.01	0.00e+00	1098.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	6.00e-67	249.00
IUUC-Mmr-061292	Microcebus murinus	98.36	0.00e+00	1095.00
IUUC-Mdo-062304	Monodelphis domestica	97.99	0.00e+00	1099.00
IUUC-Mmu-063610	Mus musculus	97.81	0.00e+00	1093.00
IUUC-Mpu-065931	Mustela putorius furo	98.36	0.00e+00	1094.00
IUUC-Mlu-066976	Myotis lucifugus	99.45	0.00e+00	1098.00
IUUC-Nle-070174	Nomascus leucogenys	98.36	0.00e+00	1095.00
IUUC-Opr-070851	Ochotona princeps	85.79	0.00e+00	644.00
IUUC-Ont-071997	Oreochromis niloticus	93.05	0.00e+00	1064.00
IUUC-Oan-072936	Ornithorhynchus anatinus	98.18	0.00e+00	1095.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.26	0.00e+00	1096.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	7.00e-30	125.00
IUUC-Ola-087098	Oryzias latipes	93.72	0.00e+00	1053.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	3.00e-38	151.00
IUUC-Oga-088884	Otolemur garnettii	99.74	0.00e+00	776.00
IUUC-Oar-090220	Ovis aries	98.53	0.00e+00	1092.00
IUUC-Ptr-090492	Pan troglodytes	98.36	0.00e+00	1095.00
IUUC-Pan-091770	Papio anubis	98.36	0.00e+00	1095.00
IUUC-Psi-093207	Pelodiscus sinensis	98.35	0.00e+00	1093.00
IUUC-Pma-094749	Petromyzon marinus	82.94	0.00e+00	941.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	1.00e-70	261.00
IUUC-Pfo-096493	Poecilia formosa	95.01	0.00e+00	1050.00
IUUC-Pab-098141	Pongo abelii	98.35	0.00e+00	1092.00
IUUC-Pca-100571	Procavia capensis	98.69	0.00e+00	773.00
IUUC-Pva-102988	Pteropus vampyrus	98.54	0.00e+00	1095.00
IUUC-Pgr-103612	Puccinia graminis	35.41	1.00e-61	231.00
IUUC-Rno-105706	Rattus norvegicus	97.63	0.00e+00	1092.00
IUUC-Sce-106343	Saccharomyces cerevisiae	30.75	4.00e-60	225.00
IUUC-Sha-107653	Sarcophilus harrisii	97.99	0.00e+00	1095.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	1.00e-78	287.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.35	4.00e-63	235.00
IUUC-Sar-113600	Sorex araneus	92.15	0.00e+00	1002.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	3.00e-67	250.00
IUUC-Ssc-115787	Sus scrofa	96.53	0.00e+00	1067.00
IUUC-Tgu-117510	Taeniopygia guttata	98.37	0.00e+00	1099.00
IUUC-Tru-117819	Takifugu rubripes	94.45	0.00e+00	1072.00
IUUC-Tsy-118828	Tarsius syrichta	98.36	0.00e+00	1094.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.42	0.00e+00	1064.00
IUUC-Tvi-122615	Trichoderma virens	34.83	1.00e-83	303.00
IUUC-Tme-127021	Tuber melanosporum	34.60	2.00e-83	303.00
IUUC-Tbe-127925	Tupaia belangeri	99.44	0.00e+00	1093.00
IUUC-Ttr-128899	Tursiops truncatus	97.99	0.00e+00	1092.00
IUUC-Uma-129449	Ustilago maydis	46.89	2.00e-66	248.00
IUUC-Vpa-130082	Vicugna pacos	98.04	0.00e+00	915.00
IUUC-Xtr-132213	Xenopus tropicalis	95.16	0.00e+00	1084.00
IUUC-Xma-133646	Xiphophorus maculatus	93.98	0.00e+00	1045.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence