iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000005949.1	ENSONIT00000007495.1	ENSONIP00000007490.1
ENSONIG00000005949.1	ENSONIT00000007496.1	ENSONIP00000007491.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.70e-07	30.1	384	422

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C+++w       +k++ CP+Cr
   Q: 384  CIICSELFIE-AVILNCAHSFCCYCINQW------RKKKDECPICR 422
           ********99.888***************......**********8 PP

Organism

Oreochromis niloticus

Functional Description
(View)

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.

Protein Sequence
(Fasta)

MDKETAADCC AVEDDECPDS EVFCLMRVGR NSDWLRLFEN TEITIGRGVD VTYQLLSPAC 60
PLMISRLHCT FKQSEDGHWT VTDKKSLNGV WVNGTRLPSD ESRQLRLGDS IQLGVPVIGN 120

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Nucleotide Sequence
(Fasta)

ATGGATAAAG AGACGGCAGC GGATTGCTGT GCGGTTGAAG ACGATGAATG TCCGGACTCG 60
GAGGTTTTTT GTCTGATGAG AGTCGGGAGA AACTCTGACT GGCTTCGCTT GTTCGAAAAC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	41.79	2.00e-62	233.00
IUUC-Apl-003664	Anas platyrhynchos	62.16	2.00e-34	137.00
IUUC-Aca-005036	Anolis carolinensis	42.12	4.00e-65	242.00
IUUC-Ame-011537	Astyanax mexicanus	54.57	9.00e-109	387.00
IUUC-Bta-013297	Bos taurus	64.08	1.00e-38	154.00
IUUC-Cja-019201	Callithrix jacchus	40.17	2.00e-66	246.00
IUUC-Cfa-021041	Canis familiaris	41.05	4.00e-68	252.00
IUUC-Csa-024133	Chlorocebus sabaeus	41.10	2.00e-68	253.00
IUUC-Cho-024624	Choloepus hoffmanni	33.41	1.00e-25	110.00
IUUC-Dre-027918	Danio rerio	55.02	2.00e-114	405.00
IUUC-Dno-029774	Dasypus novemcinctus	40.91	8.00e-70	258.00
IUUC-Dor-030190	Dipodomys ordii	35.14	9.00e-49	187.00
IUUC-Ete-032301	Echinops telfairi	37.29	7.00e-45	175.00
IUUC-Eca-033607	Equus caballus	42.38	5.00e-59	221.00
IUUC-Eeu-034888	Erinaceus europaeus	48.43	3.00e-44	172.00
IUUC-Fca-036075	Felis catus	41.97	9.00e-70	257.00
IUUC-Fal-037569	Ficedula albicollis	39.55	2.00e-61	229.00
IUUC-Gmo-038588	Gadus morhua	56.95	3.00e-128	452.00
IUUC-Gga-040777	Gallus gallus	44.35	3.00e-71	262.00
IUUC-Gac-042463	Gasterosteus aculeatus	71.87	3.00e-157	548.00
IUUC-Ggo-045269	Gorilla gorilla	40.30	7.00e-69	254.00
IUUC-Hsa-046249	Homo sapiens	40.21	4.00e-65	242.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	40.80	2.00e-71	263.00
IUUC-Lch-049805	Latimeria chalumnae	45.82	4.00e-85	308.00
IUUC-Loc-052377	Lepisosteus oculatus	49.68	1.00e-100	360.00
IUUC-Mcc-055344	Macaca mulatta	40.76	2.00e-68	253.00
IUUC-Meu-055950	Macropus eugenii	39.53	8.00e-59	221.00
IUUC-Mla-059052	Melampsora laricipopulina	37.63	9.00e-10	57.00
IUUC-Mga-060049	Meleagris gallopavo	64.46	3.00e-45	176.00
IUUC-Mmr-061431	Microcebus murinus	65.47	7.00e-38	151.00
IUUC-Mdo-062016	Monodelphis domestica	63.23	9.00e-37	150.00
IUUC-Mmu-063235	Mus musculus	41.47	9.00e-81	294.00
IUUC-Mpu-066449	Mustela putorius furo	41.86	2.00e-71	263.00
IUUC-Mlu-067588	Myotis lucifugus	41.36	4.00e-64	238.00
IUUC-Nle-069192	Nomascus leucogenys	40.98	6.00e-69	254.00
IUUC-Opr-070300	Ochotona princeps	45.70	4.00e-30	126.00
IUUC-Oan-073610	Ornithorhynchus anatinus	55.88	5.00e-46	177.00
IUUC-Ocu-074603	Oryctolagus cuniculus	41.58	5.00e-70	258.00
IUUC-Ola-086681	Oryzias latipes	64.96	1.00e-156	546.00
IUUC-Oga-088183	Otolemur garnettii	40.12	1.00e-69	257.00
IUUC-Oar-090255	Ovis aries	40.13	1.00e-60	227.00
IUUC-Ptr-091029	Pan troglodytes	39.87	7.00e-65	241.00
IUUC-Pan-092241	Papio anubis	40.98	2.00e-68	253.00
IUUC-Psi-093506	Pelodiscus sinensis	57.83	1.00e-24	107.00
IUUC-Pma-094579	Petromyzon marinus	53.76	2.00e-25	110.00
IUUC-Pfo-097014	Poecilia formosa	77.54	2.00e-166	579.00
IUUC-Pab-098530	Pongo abelii	40.82	3.00e-65	242.00
IUUC-Pca-100939	Procavia capensis	51.72	2.00e-33	137.00
IUUC-Pva-103148	Pteropus vampyrus	65.96	8.00e-34	138.00
IUUC-Rno-105338	Rattus norvegicus	41.74	2.00e-80	293.00
IUUC-Sha-107187	Sarcophilus harrisii	64.29	9.00e-46	177.00
IUUC-Sar-113356	Sorex araneus	37.32	5.00e-44	171.00
IUUC-Ssc-116290	Sus scrofa	41.79	1.00e-74	274.00
IUUC-Tru-117910	Takifugu rubripes	69.41	3.00e-160	558.00
IUUC-Tsy-119329	Tarsius syrichta	62.86	3.00e-35	142.00
IUUC-Tni-120521	Tetraodon nigroviridis	69.21	1.00e-149	523.00
IUUC-Ttr-128997	Tursiops truncatus	34.73	8.00e-55	207.00
IUUC-Vda-129982	Verticillium dahliae	28.10	7.00e-08	52.40
IUUC-Vpa-130154	Vicugna pacos	38.57	6.00e-66	244.00
IUUC-Xtr-132805	Xenopus tropicalis	55.21	5.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence