iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013187

Ensembl Protein ID

ENSBTAP00000052507.2

UniProt Accession

Q2HJD0; FAF2_BOVIN

Genbank Protein ID

AAI05573.1

Protein Name

FAS-associated factor 2; UBX domain-containing protein 8

Genbank Nucleotide ID

BC105572

Gene Name

FAF2; UBXD8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000017744.5	ENSBTAT00000057329.2	ENSBTAP00000052507.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	5.30e-07	29.7	12	48
ULD/UDP/UFD/UBX	4.30e-17	62.6	358	439

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlve.MGF.dreealqaLraannnleaAve 36
           e+++kl q+++ +G+ + ++++  L+++n+n+eaAv 
   Q: 12   EQTEKLLQFQDlTGIeSMDQCRHTLEQHNWNIEAAVQ 48
           799********************************95 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehms.....tlqeagLvpsgsllv 79
           ++e++++ ++lp+++r++r+F+ s++l+ i++f+  +l+es ++F++ ++fPrr l +  +++     tlqeagL ++++l+v
   Q: 358  DPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLF-SLKESPEKFQIEANFPRRVLPCLPSEEwpnppTLQEAGLSHTEVLFV 439
           56799******************************.*************************99******************98 PP

Organism

Bos taurus

Functional Description
(View)

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.

Protein Sequence
(Fasta)

MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV 60
FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGAGGCGGC GGCAAAATGG CGGCGCCTGA GGAGCGGGAT CTAACCCAGG AGCAGACAGA 60
GAAGCTGCTG CAGTTTCAGG TAGCAGCGAG CACTCGGTGC AGCGAATGTT GCCGCGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0551--Lipid droplet
KW-1185--Reference proteome
KW-0834--Unfolded protein response

Interpro

IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

SMART

SM00594--UAS

Gene Ontology

GO:0005811--C:lipid particle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0055102--F:lipase inhibitor activity
GO:0034389--P:lipid particle organization
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

bta:767948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000466	Aegilops tauschii	32.02	1.00e-21	97.40
IUUC-Aml-001491	Ailuropoda melanoleuca	96.84	0.00e+00	810.00
IUUC-Atr-002715	Amborella trichopoda	29.00	3.00e-29	123.00
IUUC-Apl-003340	Anas platyrhynchos	87.04	0.00e+00	748.00
IUUC-Aca-004296	Anolis carolinensis	91.26	0.00e+00	778.00
IUUC-Aly-006114	Arabidopsis lyrata	31.72	4.00e-17	82.80
IUUC-Ath-007354	Arabidopsis thaliana	31.21	2.00e-20	94.00
IUUC-Ago-007775	Ashbya gossypii	30.64	3.00e-12	66.60
IUUC-Acl-008096	Aspergillus clavatus	32.84	2.00e-26	113.00
IUUC-Afl-008447	Aspergillus flavus	32.16	8.00e-25	108.00
IUUC-Afu-008836	Aspergillus fumigatus	30.77	2.00e-24	107.00
IUUC-Ani-009247	Aspergillus nidulans	31.92	3.00e-24	106.00
IUUC-Ang-009721	Aspergillus niger	31.80	3.00e-25	110.00
IUUC-Aor-010080	Aspergillus oryzae	32.16	3.00e-24	106.00
IUUC-Ate-010379	Aspergillus terreus	33.46	6.00e-25	108.00
IUUC-Ame-010880	Astyanax mexicanus	78.60	0.00e+00	694.00
IUUC-Bgr-012032	Blumeria graminis	23.56	8.00e-20	91.70
IUUC-Bci-013871	Botrytis cinerea	34.94	5.00e-20	92.40
IUUC-Bdi-014964	Brachypodium distachyon	33.53	9.00e-21	94.70
IUUC-Bol-016064	Brassica oleracea	34.18	7.00e-21	95.10
IUUC-Bra-017693	Brassica rapa	32.56	7.00e-22	98.60
IUUC-Cel-018580	Caenorhabditis elegans	25.53	1.00e-04	40.80
IUUC-Cja-018867	Callithrix jacchus	92.79	0.00e+00	764.00
IUUC-Cfa-020467	Canis familiaris	99.33	0.00e+00	841.00
IUUC-Cpo-021987	Cavia porcellus	79.38	0.00e+00	707.00
IUUC-Cre-022908	Chlamydomonas reinhardtii	32.80	1.00e-16	81.30
IUUC-Csa-024081	Chlorocebus sabaeus	99.33	0.00e+00	841.00
IUUC-Cho-024488	Choloepus hoffmanni	98.65	0.00e+00	821.00
IUUC-Cin-025394	Ciona intestinalis	39.17	1.00e-60	226.00
IUUC-Csv-025919	Ciona savignyi	41.21	7.00e-66	243.00
IUUC-Cgl-026662	Colletotrichum gloeosporioides	29.44	1.00e-22	101.00
IUUC-Cne-027035	Cryptococcus neoformans	28.28	4.00e-07	49.70
IUUC-Cme-027217	Cyanidioschyzon merolae	23.63	5.00e-15	75.90
IUUC-Dre-028783	Danio rerio	83.82	0.00e+00	699.00
IUUC-Dno-029386	Dasypus novemcinctus	98.88	0.00e+00	828.00
IUUC-Dor-030740	Dipodomys ordii	74.81	2.00e-106	378.00
IUUC-Dse-031166	Dothistroma septosporum	31.21	2.00e-21	97.10
IUUC-Dme-031737	Drosophila melanogaster	42.64	1.00e-85	310.00
IUUC-Ete-033173	Echinops telfairi	98.20	0.00e+00	796.00
IUUC-Eca-033257	Equus caballus	98.66	0.00e+00	835.00
IUUC-Eeu-034927	Erinaceus europaeus	85.88	6.00e-149	520.00
IUUC-Fca-036165	Felis catus	99.33	0.00e+00	841.00
IUUC-Fal-037552	Ficedula albicollis	93.71	0.00e+00	802.00
IUUC-Fox-038042	Fusarium oxysporum	33.53	3.00e-22	99.80
IUUC-Fso-038157	Fusarium solani	28.15	3.00e-21	96.70
IUUC-Gmo-039281	Gadus morhua	84.49	0.00e+00	707.00
IUUC-Ggr-040025	Gaeumannomyces graminis	24.50	3.00e-16	79.70
IUUC-Gga-040656	Gallus gallus	93.93	0.00e+00	806.00
IUUC-Gac-041548	Gasterosteus aculeatus	84.04	0.00e+00	677.00
IUUC-Gma-043686	Glycine max	30.77	5.00e-22	99.00
IUUC-Ggo-044463	Gorilla gorilla	99.33	0.00e+00	841.00
IUUC-Hsa-045993	Homo sapiens	99.10	0.00e+00	840.00
IUUC-Hvu-047443	Hordeum vulgare	32.17	2.00e-16	79.30
IUUC-Itr-047969	Ictidomys tridecemlineatus	97.77	0.00e+00	719.00
IUUC-Kpa-049282	Komagataella pastoris	21.75	1.00e-17	84.30
IUUC-Lch-049899	Latimeria chalumnae	87.87	0.00e+00	726.00
IUUC-Lpe-050745	Leersia perrieri	35.76	1.00e-19	92.00
IUUC-Loc-052363	Lepisosteus oculatus	87.87	0.00e+00	762.00
IUUC-Lma-053279	Leptosphaeria maculans	29.79	2.00e-20	94.00
IUUC-Laf-054194	Loxodonta africana	96.56	0.00e+00	759.00
IUUC-Mcc-055811	Macaca mulatta	99.33	0.00e+00	841.00
IUUC-Meu-056391	Macropus eugenii	96.88	6.00e-100	357.00
IUUC-Mor-057016	Magnaporthe oryzae	25.95	3.00e-22	100.00
IUUC-Mpo-057383	Magnaporthe poae	30.06	5.00e-15	75.90
IUUC-Mtr-058297	Medicago truncatula	24.92	2.00e-26	113.00
IUUC-Mla-059091	Melampsora laricipopulina	29.39	1.00e-08	55.10
IUUC-Mga-059518	Meleagris gallopavo	93.88	0.00e+00	768.00
IUUC-Mvi-060414	Microbotryum violaceum	30.25	8.00e-11	62.40
IUUC-Mmr-061274	Microcebus murinus	99.10	0.00e+00	840.00
IUUC-Mdo-061873	Monodelphis domestica	94.68	0.00e+00	793.00
IUUC-Mmu-063992	Mus musculus	97.08	0.00e+00	825.00
IUUC-Mac-064544	Musa acuminata	32.50	2.00e-16	80.10
IUUC-Mpu-066089	Mustela putorius furo	99.10	0.00e+00	840.00
IUUC-Mlu-067041	Myotis lucifugus	98.20	0.00e+00	811.00
IUUC-Nfi-068382	Neosartorya fischeri	31.15	2.00e-24	107.00
IUUC-Ncr-068916	Neurospora crassa	31.14	3.00e-23	102.00
IUUC-Nle-069007	Nomascus leucogenys	99.06	0.00e+00	803.00
IUUC-Opr-070477	Ochotona princeps	87.42	0.00e+00	705.00
IUUC-Ont-072076	Oreochromis niloticus	87.64	0.00e+00	717.00
IUUC-Oan-073466	Ornithorhynchus anatinus	78.07	1.00e-162	566.00
IUUC-Ocu-073830	Oryctolagus cuniculus	98.65	0.00e+00	824.00
IUUC-Oba-075714	Oryza barthii	35.10	4.00e-19	90.10
IUUC-Obr-076861	Oryza brachyantha	33.53	9.00e-22	97.80
IUUC-Ogl-077668	Oryza glaberrima	26.44	7.00e-22	98.20
IUUC-Ogu-078916	Oryza glumaepatula	35.10	2.00e-19	90.10
IUUC-Oin-079308	Oryza indica	35.10	3.00e-19	89.70
IUUC-Olo-080935	Oryza longistaminata	35.34	3.00e-17	84.00
IUUC-Ome-081526	Oryza meridionalis	35.10	3.00e-19	89.70
IUUC-Oni-083120	Oryza nivara	35.10	2.00e-19	90.10
IUUC-Opu-084064	Oryza punctata	35.10	3.00e-19	89.70
IUUC-Oru-084948	Oryza rufipogon	35.10	3.00e-19	89.70
IUUC-Osa-086165	Oryza sativa	35.10	3.00e-19	89.70
IUUC-Ola-086916	Oryzias latipes	86.97	0.00e+00	712.00
IUUC-Olu-087751	Ostreococcus lucimarinus	25.71	6.00e-12	64.70
IUUC-Oga-088269	Otolemur garnettii	96.60	0.00e+00	788.00
IUUC-Oar-089219	Ovis aries	99.30	0.00e+00	808.00
IUUC-Ptr-090759	Pan troglodytes	99.33	0.00e+00	841.00
IUUC-Pan-092145	Papio anubis	99.33	0.00e+00	841.00
IUUC-Psi-093285	Pelodiscus sinensis	94.10	5.00e-162	563.00
IUUC-Pno-095142	Phaeosphaeria nodorum	33.53	4.00e-26	112.00
IUUC-Ppa-095784	Physcomitrella patens	23.80	4.00e-24	106.00
IUUC-Pfo-097425	Poecilia formosa	85.84	0.00e+00	716.00
IUUC-Pab-098443	Pongo abelii	99.33	0.00e+00	841.00
IUUC-Pop-099217	Populus trichocarpa	28.10	1.00e-34	140.00
IUUC-Pca-100699	Procavia capensis	78.49	3.00e-123	435.00
IUUC-Ppe-101800	Prunus persica	26.63	6.00e-26	112.00
IUUC-Pva-103145	Pteropus vampyrus	97.89	5.00e-142	497.00
IUUC-Pgr-103629	Puccinia graminis	28.39	2.00e-10	60.50
IUUC-Ptt-103793	Puccinia triticina	27.94	2.00e-14	74.30
IUUC-Pte-104225	Pyrenophora teres	29.11	8.00e-25	108.00
IUUC-Pyt-104700	Pyrenophora triticirepentis	33.44	1.00e-24	107.00
IUUC-Rno-106093	Rattus norvegicus	96.85	0.00e+00	823.00
IUUC-Sce-106313	Saccharomyces cerevisiae	28.90	1.00e-12	68.20
IUUC-Sha-106741	Sarcophilus harrisii	85.37	0.00e+00	644.00
IUUC-Sja-107815	Schizosaccharomyces japonicus	26.35	2.00e-15	76.60
IUUC-Spo-108055	Schizosaccharomyces pombe	25.72	2.00e-11	63.50
IUUC-Smo-109471	Selaginella moellendorffii	29.37	2.00e-20	94.00
IUUC-Sit-110718	Setaria italica	36.05	3.00e-20	93.20
IUUC-Sly-111335	Solanum lycopersicum	33.14	6.00e-23	101.00
IUUC-Stu-112406	Solanum tuberosum	34.39	1.00e-20	94.00
IUUC-Sar-113215	Sorex araneus	91.69	6.00e-179	619.00
IUUC-Sbi-114324	Sorghum bicolor	37.74	6.00e-23	102.00
IUUC-Sre-114905	Sporisorium reilianum	29.55	4.00e-13	69.70
IUUC-Ssc-116024	Sus scrofa	98.83	0.00e+00	805.00
IUUC-Tgu-117287	Taeniopygia guttata	94.16	0.00e+00	805.00
IUUC-Tru-118546	Takifugu rubripes	84.94	0.00e+00	684.00
IUUC-Tsy-119080	Tarsius syrichta	98.18	5.00e-132	464.00
IUUC-Tni-120327	Tetraodon nigroviridis	67.46	8.00e-159	553.00
IUUC-Tca-121139	Theobroma cacao	30.28	2.00e-20	93.20
IUUC-Tre-121891	Trichoderma reesei	32.26	1.00e-13	70.90
IUUC-Tvi-122596	Trichoderma virens	27.64	3.00e-21	96.30
IUUC-Tae-125206	Triticum aestivum	34.50	8.00e-23	101.00
IUUC-Tur-126427	Triticum urartu	32.17	1.00e-16	80.10
IUUC-Tme-126896	Tuber melanosporum	38.55	2.00e-25	110.00
IUUC-Tbe-127474	Tupaia belangeri	84.91	0.00e+00	709.00
IUUC-Ttr-128455	Tursiops truncatus	87.42	0.00e+00	743.00
IUUC-Uma-129503	Ustilago maydis	32.17	2.00e-09	57.80
IUUC-Vda-129700	Verticillium dahliae	28.81	4.00e-25	109.00
IUUC-Vpa-130516	Vicugna pacos	88.76	0.00e+00	704.00
IUUC-Vvi-131232	Vitis vinifera	31.32	1.00e-27	117.00
IUUC-Xtr-132664	Xenopus tropicalis	84.94	0.00e+00	701.00
IUUC-Xma-133998	Xiphophorus maculatus	86.52	0.00e+00	719.00
IUUC-Yli-134397	Yarrowia lipolytica	29.96	6.00e-24	105.00
IUUC-Zma-134832	Zea mays	36.42	2.00e-20	94.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence