iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	20059542; 20086187; 21764993
ULD/UDP/UFD/MUB	MUB	20086187; 25320573

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	6.10e-23	81.1	187	228
ULD/UDP/UBQ/UBQ_PIM	2.60e-25	89.0	1	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMG...FdreealqaLraannnleaAveyLldg 41
           +e+ ++q+ +MG   +dre+++ aLraa+nn+e+AveyL++g
   Q: 187  LESTIQQILDMGggtWDRETVVLALRAAFNNPERAVEYLYTG 228
           799*************************************87 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mk++vktlkg++fe+ev+++d+v ++K++i++++g   +p+++q LI++Gk+LkD+tt++e+++ ++s+++++++ksk
   Q: 1    MKIFVKTLKGTHFEIEVKPEDSVVDVKKNIESVQGadvYPAAKQMLIHQGKVLKDETTIEENKVAENSFIVIMMNKSK 78
           99************************************************************************9997 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).

Protein Sequence
(Fasta)

MKIFVKTLKG THFEIEVKPE DSVVDVKKNI ESVQGADVYP AAKQMLIHQG KVLKDETTIE 60
ENKVAENSFI VIMMNKSKPA SAAASSASAG TSQAKSIPPS TSQPSISPQT PASVSAPVAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAGGAAAT TGTCAATACC ACGTGGCATA TTTTAATAGG ATAATGGCGG CTGACCTGGC 60
AGAGTTGAAA GCACAAGCCA TGTGCTTCGG GTGTGATCCA GTGGAGATAT CGAGGGAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0006289--P:nucleotide-excision repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G02540

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001195	Ailuropoda melanoleuca	39.62	4.00e-31	128.00
IUUC-Atr-003116	Amborella trichopoda	78.49	2.00e-98	352.00
IUUC-Apl-003371	Anas platyrhynchos	38.70	1.00e-34	139.00
IUUC-Aca-004599	Anolis carolinensis	39.45	2.00e-29	122.00
IUUC-Aly-005498	Arabidopsis lyrata	97.60	2.00e-127	448.00
IUUC-Ame-011107	Astyanax mexicanus	42.21	1.00e-28	120.00
IUUC-Bgr-012056	Blumeria graminis	31.31	1.00e-31	129.00
IUUC-Bdi-014253	Brachypodium distachyon	66.80	2.00e-84	305.00
IUUC-Bol-015641	Brassica oleracea	76.94	4.00e-140	490.00
IUUC-Bra-017983	Brassica rapa	77.14	2.00e-149	521.00
IUUC-Cfa-020683	Canis familiaris	38.97	5.00e-30	124.00
IUUC-Cpo-022145	Cavia porcellus	40.98	1.00e-35	143.00
IUUC-Cre-022810	Chlamydomonas reinhardtii	35.34	2.00e-22	99.40
IUUC-Csa-023714	Chlorocebus sabaeus	38.32	6.00e-34	137.00
IUUC-Ete-032583	Echinops telfairi	40.00	7.00e-21	94.40
IUUC-Eeu-034721	Erinaceus europaeus	40.00	9.00e-21	93.60
IUUC-Gac-042298	Gasterosteus aculeatus	35.75	3.00e-42	164.00
IUUC-Gma-043937	Glycine max	80.88	7.00e-111	393.00
IUUC-Ggo-045125	Gorilla gorilla	38.55	5.00e-33	134.00
IUUC-Hsa-046519	Homo sapiens	38.55	5.00e-33	134.00
IUUC-Lch-050553	Latimeria chalumnae	41.98	2.00e-29	122.00
IUUC-Laf-054293	Loxodonta africana	39.68	5.00e-32	131.00
IUUC-Mcc-055600	Macaca mulatta	38.32	2.00e-33	135.00
IUUC-Mmr-061159	Microcebus murinus	39.44	1.00e-32	133.00
IUUC-Mmu-063258	Mus musculus	39.11	3.00e-36	145.00
IUUC-Mac-064724	Musa acuminata	63.51	3.00e-132	464.00
IUUC-Nle-069655	Nomascus leucogenys	38.32	9.00e-34	137.00
IUUC-Ont-072484	Oreochromis niloticus	36.34	2.00e-52	199.00
IUUC-Olo-081091	Oryza longistaminata	63.41	7.00e-85	307.00
IUUC-Ptr-091165	Pan troglodytes	38.55	8.00e-33	133.00
IUUC-Pan-092009	Papio anubis	38.27	2.00e-32	132.00
IUUC-Psi-093477	Pelodiscus sinensis	40.89	2.00e-28	119.00
IUUC-Pgr-103618	Puccinia graminis	39.78	9.00e-29	120.00
IUUC-Ptt-103717	Puccinia triticina	47.45	1.00e-26	113.00
IUUC-Rno-104844	Rattus norvegicus	39.26	1.00e-35	143.00
IUUC-Sha-107073	Sarcophilus harrisii	39.75	2.00e-30	125.00
IUUC-Sly-111609	Solanum lycopersicum	75.70	5.00e-98	350.00
IUUC-Stu-112027	Solanum tuberosum	65.58	1.00e-145	508.00
IUUC-Sar-112925	Sorex araneus	40.34	9.00e-29	120.00
IUUC-Sre-114894	Sporisorium reilianum	55.00	2.00e-12	66.60
IUUC-Tgu-116918	Taeniopygia guttata	38.95	4.00e-34	138.00
IUUC-Tru-117920	Takifugu rubripes	42.28	8.00e-44	170.00
IUUC-Tni-120493	Tetraodon nigroviridis	44.05	5.00e-43	167.00
IUUC-Vvi-130842	Vitis vinifera	84.13	8.00e-109	386.00
IUUC-Xtr-132679	Xenopus tropicalis	38.66	2.00e-23	102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence