iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097560

Ensembl Protein ID

ENSPPYP00000002431.2

UniProt Accession

H2N9S6; H2N9S6_PONAB

Genbank Protein ID

ENSPPYP00000002431

Protein Name

Optineurin

Genbank Nucleotide ID

ABGA01070254

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000002095.2	ENSPPYT00000002505.2	ENSPPYP00000002431.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.00e-25	89.5	409	468

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++e+ke+L+ q+++l+k++++++d++++s
   Q: 409  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEQKEQLALQLAVLLKENDAFEDGGRQS 468
           79********************************************************98 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSHQPLSCLT EKEDSPTEST GNGPPYLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCCCTGGT CAGCGTCCCA TCCCGGACGG GAGTTCTCTC CAGGCGGCAC GATGCCGAGG 60
AAACAGTGAC CCTGAGCGAA GCCAAGCCGG GCGGCAGGTG AGCCAGGGCA GGGGGCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	74.08	0.00e+00	674.00
IUUC-Apl-003812	Anas platyrhynchos	62.64	5.00e-105	374.00
IUUC-Aca-004625	Anolis carolinensis	51.21	1.00e-122	433.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	1.90e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	47.39	2.00e-55	210.00
IUUC-Bta-013240	Bos taurus	73.89	0.00e+00	761.00
IUUC-Cja-019911	Callithrix jacchus	84.40	0.00e+00	825.00
IUUC-Cfa-020330	Canis familiaris	77.07	0.00e+00	721.00
IUUC-Cpo-021753	Cavia porcellus	73.96	0.00e+00	712.00
IUUC-Csa-023662	Chlorocebus sabaeus	83.05	0.00e+00	825.00
IUUC-Cho-024574	Choloepus hoffmanni	67.18	5.00e-126	444.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	2.00e-03	37.00
IUUC-Dre-027720	Danio rerio	40.07	2.00e-78	286.00
IUUC-Dno-029079	Dasypus novemcinctus	80.51	1.00e-147	516.00
IUUC-Dor-030890	Dipodomys ordii	70.65	0.00e+00	714.00
IUUC-Ete-032568	Echinops telfairi	70.24	1.00e-179	622.00
IUUC-Eca-033528	Equus caballus	73.06	0.00e+00	715.00
IUUC-Eeu-035219	Erinaceus europaeus	67.41	0.00e+00	698.00
IUUC-Fca-035852	Felis catus	76.45	0.00e+00	713.00
IUUC-Fal-036862	Ficedula albicollis	55.99	3.00e-131	462.00
IUUC-Gmo-038735	Gadus morhua	38.10	1.00e-68	253.00
IUUC-Gga-040939	Gallus gallus	66.67	2.00e-25	110.00
IUUC-Gac-041580	Gasterosteus aculeatus	40.21	6.00e-83	301.00
IUUC-Ggo-045034	Gorilla gorilla	73.97	0.00e+00	760.00
IUUC-Hsa-046624	Homo sapiens	88.39	0.00e+00	904.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	71.31	0.00e+00	703.00
IUUC-Lch-049720	Latimeria chalumnae	44.33	5.00e-63	234.00
IUUC-Loc-052185	Lepisosteus oculatus	43.63	5.00e-90	325.00
IUUC-Laf-054079	Loxodonta africana	65.56	4.00e-171	594.00
IUUC-Mcc-055674	Macaca mulatta	86.66	0.00e+00	831.00
IUUC-Meu-056769	Macropus eugenii	82.74	1.00e-72	267.00
IUUC-Mga-060203	Meleagris gallopavo	55.41	2.00e-126	446.00
IUUC-Mmr-061492	Microcebus murinus	75.30	0.00e+00	719.00
IUUC-Mdo-063051	Monodelphis domestica	68.32	0.00e+00	694.00
IUUC-Mmu-063409	Mus musculus	68.73	0.00e+00	716.00
IUUC-Mpu-065907	Mustela putorius furo	70.37	0.00e+00	703.00
IUUC-Mlu-066957	Myotis lucifugus	72.73	0.00e+00	663.00
IUUC-Ncr-068766	Neurospora crassa	32.69	3.10e-01	30.00
IUUC-Nle-069973	Nomascus leucogenys	87.69	0.00e+00	882.00
IUUC-Opr-071049	Ochotona princeps	78.92	1.00e-141	496.00
IUUC-Ont-071915	Oreochromis niloticus	41.49	2.00e-81	296.00
IUUC-Oan-072965	Ornithorhynchus anatinus	67.53	0.00e+00	664.00
IUUC-Ocu-074029	Oryctolagus cuniculus	74.80	5.00e-174	603.00
IUUC-Ola-087019	Oryzias latipes	38.12	2.00e-79	290.00
IUUC-Oga-088613	Otolemur garnettii	76.54	0.00e+00	755.00
IUUC-Oar-090386	Ovis aries	72.87	0.00e+00	743.00
IUUC-Ptr-091619	Pan troglodytes	88.21	0.00e+00	900.00
IUUC-Pan-092178	Papio anubis	82.11	0.00e+00	812.00
IUUC-Psi-093214	Pelodiscus sinensis	56.85	1.00e-138	486.00
IUUC-Pfo-096901	Poecilia formosa	38.84	7.00e-71	261.00
IUUC-Pca-100853	Procavia capensis	62.65	2.00e-92	332.00
IUUC-Pva-102255	Pteropus vampyrus	73.20	0.00e+00	661.00
IUUC-Rno-105812	Rattus norvegicus	72.01	0.00e+00	733.00
IUUC-Sha-107225	Sarcophilus harrisii	79.68	9.00e-159	552.00
IUUC-Sar-113736	Sorex araneus	73.22	4.00e-131	461.00
IUUC-Ssc-115422	Sus scrofa	73.24	0.00e+00	751.00
IUUC-Tgu-116924	Taeniopygia guttata	61.97	7.00e-109	387.00
IUUC-Tru-117695	Takifugu rubripes	43.47	3.00e-65	242.00
IUUC-Tsy-119090	Tarsius syrichta	73.18	1.00e-121	429.00
IUUC-Tni-120645	Tetraodon nigroviridis	38.65	3.00e-77	282.00
IUUC-Tbe-127970	Tupaia belangeri	71.72	2.00e-135	476.00
IUUC-Ttr-129244	Tursiops truncatus	74.87	0.00e+00	716.00
IUUC-Vpa-130313	Vicugna pacos	75.30	0.00e+00	709.00
IUUC-Xtr-132115	Xenopus tropicalis	41.01	2.00e-80	292.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence