iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091607

Ensembl Protein ID

ENSPTRP00000018851.2

UniProt Accession

H2QGC0; H2QGC0_PANTR

Genbank Protein ID

JAA03326.1; JAA25209.1

Protein Name

Mitogen-activated protein kinase kinase kinase 10

Genbank Nucleotide ID

AACZ03119026; GABD01007891

Gene Name

MAP3K10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000010989.2	ENSPTRT00000020381.2	ENSPTRP00000018851.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.10e-15	54.4	22	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvieke...eqdegWlkgvkelegkrGlfPenFve 60
            + +dyea+ d+eLtl++Gd v+v++++   + degW+ g+   +g+ G+fP+n+v+
   Q: 22   TAVFDYEAAGDEELTLRRGDRVQVLSQDcavSGDEGWWTGQ-LPSGRVGVFPSNYVA 77
           589**********************77622257*******7.99***********96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MEEEEGAVAK EWGTTPAGPV WTAVFDYEAA GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPGA PAAPAGLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCAGCCA GGCCCTCTTA GCCCTCTGCC GTTTGGGGGG CACGGGTGAA CCTGCCGCCC 60
CACTCCCACC CCGCCCCGCC CCTACAGCCA AATCGGAAGG GACGAGCCTG CCCTTTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR015785--MAP3K10
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0003714--F:transcription corepressor activity
GO:0007257--P:activation of JUN kinase activity
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0007224--P:smoothened signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001187	Ailuropoda melanoleuca	96.08	0.00e+00	1007.00
IUUC-Atr-002478	Amborella trichopoda	33.33	1.00e-23	105.00
IUUC-Aca-004768	Anolis carolinensis	72.44	0.00e+00	816.00
IUUC-Aly-006459	Arabidopsis lyrata	33.45	3.00e-29	124.00
IUUC-Ath-006581	Arabidopsis thaliana	33.10	2.00e-28	121.00
IUUC-Bta-013545	Bos taurus	98.50	0.00e+00	830.00
IUUC-Bdi-014449	Brachypodium distachyon	32.36	1.00e-25	111.00
IUUC-Bol-016287	Brassica oleracea	32.38	4.00e-28	120.00
IUUC-Bra-017021	Brassica rapa	33.10	2.00e-28	121.00
IUUC-Cja-019696	Callithrix jacchus	91.65	0.00e+00	1349.00
IUUC-Cfa-020789	Canis familiaris	79.14	0.00e+00	1084.00
IUUC-Cpo-021993	Cavia porcellus	90.68	0.00e+00	958.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	33.64	2.00e-19	90.10
IUUC-Csa-024243	Chlorocebus sabaeus	98.53	0.00e+00	1398.00
IUUC-Cho-024961	Choloepus hoffmanni	93.33	3.00e-107	382.00
IUUC-Dre-028573	Danio rerio	71.29	0.00e+00	769.00
IUUC-Dno-029095	Dasypus novemcinctus	91.36	0.00e+00	1223.00
IUUC-Fca-036250	Felis catus	97.23	0.00e+00	991.00
IUUC-Gmo-038497	Gadus morhua	71.38	0.00e+00	764.00
IUUC-Gma-043336	Glycine max	29.87	1.00e-25	111.00
IUUC-Ggo-045471	Gorilla gorilla	92.79	0.00e+00	956.00
IUUC-Hsa-046936	Homo sapiens	99.90	0.00e+00	1444.00
IUUC-Hvu-047798	Hordeum vulgare	33.62	5.00e-24	106.00
IUUC-Itr-048231	Ictidomys tridecemlineatus	95.84	0.00e+00	982.00
IUUC-Loc-052286	Lepisosteus oculatus	67.64	0.00e+00	755.00
IUUC-Mcc-055733	Macaca mulatta	96.57	0.00e+00	1394.00
IUUC-Mtr-058733	Medicago truncatula	32.00	5.00e-26	113.00
IUUC-Mdo-062516	Monodelphis domestica	73.05	0.00e+00	1027.00
IUUC-Mmu-064082	Mus musculus	90.85	0.00e+00	1412.00
IUUC-Mac-065156	Musa acuminata	31.58	8.00e-27	115.00
IUUC-Mpu-065934	Mustela putorius furo	92.34	0.00e+00	1311.00
IUUC-Mlu-068137	Myotis lucifugus	80.61	0.00e+00	1228.00
IUUC-Opr-070869	Ochotona princeps	78.39	0.00e+00	877.00
IUUC-Ont-072492	Oreochromis niloticus	63.83	0.00e+00	781.00
IUUC-Ocu-074350	Oryctolagus cuniculus	90.52	0.00e+00	1217.00
IUUC-Oba-075616	Oryza barthii	34.88	2.00e-24	107.00
IUUC-Obr-076215	Oryza brachyantha	34.91	1.00e-25	111.00
IUUC-Ogl-077159	Oryza glaberrima	34.88	2.00e-24	107.00
IUUC-Ogu-078228	Oryza glumaepatula	35.35	7.00e-25	108.00
IUUC-Oin-079079	Oryza indica	34.93	5.00e-25	109.00
IUUC-Olo-080886	Oryza longistaminata	35.07	3.00e-24	106.00
IUUC-Oni-082428	Oryza nivara	34.88	2.00e-24	107.00
IUUC-Opu-083527	Oryza punctata	35.35	1.00e-24	108.00
IUUC-Oru-084678	Oryza rufipogon	34.93	5.00e-25	109.00
IUUC-Osa-086117	Oryza sativa	34.93	5.00e-25	109.00
IUUC-Oga-088351	Otolemur garnettii	92.90	0.00e+00	1355.00
IUUC-Pan-092403	Papio anubis	99.11	0.00e+00	1003.00
IUUC-Pfo-096104	Poecilia formosa	60.39	0.00e+00	787.00
IUUC-Pab-098396	Pongo abelii	99.56	0.00e+00	1059.00
IUUC-Pop-099554	Populus trichocarpa	29.59	1.00e-23	105.00
IUUC-Ppe-101208	Prunus persica	31.93	2.00e-25	111.00
IUUC-Pva-103086	Pteropus vampyrus	96.30	3.00e-179	622.00
IUUC-Rno-105688	Rattus norvegicus	90.74	0.00e+00	1420.00
IUUC-Smo-109113	Selaginella moellendorffii	33.09	8.00e-26	110.00
IUUC-Sit-110427	Setaria italica	34.58	1.00e-24	108.00
IUUC-Sly-111849	Solanum lycopersicum	35.09	3.00e-25	110.00
IUUC-Stu-112224	Solanum tuberosum	35.09	4.00e-25	109.00
IUUC-Sbi-113963	Sorghum bicolor	35.05	3.00e-25	110.00
IUUC-Ssc-115332	Sus scrofa	95.85	0.00e+00	981.00
IUUC-Tru-117692	Takifugu rubripes	63.48	0.00e+00	799.00
IUUC-Tsy-119412	Tarsius syrichta	94.85	1.00e-66	247.00
IUUC-Tca-121565	Theobroma cacao	35.85	9.00e-26	112.00
IUUC-Tae-125555	Triticum aestivum	32.10	2.00e-24	107.00
IUUC-Tur-126322	Triticum urartu	32.26	8.00e-25	108.00
IUUC-Tbe-127643	Tupaia belangeri	98.55	0.00e+00	667.00
IUUC-Ttr-128550	Tursiops truncatus	91.10	0.00e+00	1342.00
IUUC-Vvi-131372	Vitis vinifera	32.62	1.00e-23	105.00
IUUC-Xtr-132108	Xenopus tropicalis	62.25	0.00e+00	959.00
IUUC-Xma-134254	Xiphophorus maculatus	60.30	0.00e+00	807.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence