iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092748

Ensembl Protein ID

ENSPANP00000001291.1

UniProt Accession

A0A096MNN2; A0A096MNN2_PAPAN

Genbank Protein ID

ENSPANP00000001291

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHZZ01086247

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000012532.1	ENSPANT00000028002.1	ENSPANP00000001291.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-97	326.1	273	677

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+            +         +                                   
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavtasE---------Kkrsfckhppvtdtvyqmnecqekdtgfvrsrqssl 352
           7******************************8777665555542.........133444455688888888888888889999888888 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 353  ssglsggasksrkmeliqprepTSQYLSLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL-- 439
           888888888777777777766555566************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 440  -------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqpcLVTEML 521
           .......7889999999999************************************************9998877788888889***** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 522  AKFTETEALEGKI-YVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRET 608
           **********965.*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 609  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 677
           88876779***************************9999********************...********98 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MLTMDKCKHV GQLRLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HCMTRSGMVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCGCCGGA CCGGGTCGCC GCGGCCGCCG AACCGGGGTG CGGGGGGCCG GGGTGAGCGC 60
TAAGATGGCC GCCCCGGCTC GGGCTGGTGA GTGTGAGCGA GGGCGCGGGC CGGGGTGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	92.13	0.00e+00	1326.00
IUUC-Apl-003673	Anas platyrhynchos	75.60	0.00e+00	1058.00
IUUC-Aca-004434	Anolis carolinensis	73.72	0.00e+00	1011.00
IUUC-Ame-010986	Astyanax mexicanus	63.57	0.00e+00	877.00
IUUC-Bta-012774	Bos taurus	89.89	0.00e+00	1281.00
IUUC-Cja-019619	Callithrix jacchus	93.41	0.00e+00	1321.00
IUUC-Cfa-020957	Canis familiaris	90.73	0.00e+00	1324.00
IUUC-Csa-023177	Chlorocebus sabaeus	98.74	0.00e+00	1385.00
IUUC-Cho-024877	Choloepus hoffmanni	88.47	0.00e+00	839.00
IUUC-Csv-025814	Ciona savignyi	44.35	2.00e-151	529.00
IUUC-Dre-027878	Danio rerio	63.96	0.00e+00	850.00
IUUC-Dno-029832	Dasypus novemcinctus	91.99	0.00e+00	1332.00
IUUC-Ete-032627	Echinops telfairi	86.54	0.00e+00	1249.00
IUUC-Eca-033863	Equus caballus	86.88	0.00e+00	1220.00
IUUC-Eeu-035225	Erinaceus europaeus	86.94	0.00e+00	1207.00
IUUC-Fca-036288	Felis catus	91.85	0.00e+00	1326.00
IUUC-Fal-037207	Ficedula albicollis	74.61	0.00e+00	1019.00
IUUC-Gga-040457	Gallus gallus	74.93	0.00e+00	1021.00
IUUC-Ggo-044926	Gorilla gorilla	95.37	0.00e+00	1340.00
IUUC-Hsa-046079	Homo sapiens	95.37	0.00e+00	1340.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	90.60	0.00e+00	1284.00
IUUC-Lch-050260	Latimeria chalumnae	67.28	0.00e+00	925.00
IUUC-Laf-054491	Loxodonta africana	88.68	0.00e+00	1225.00
IUUC-Mcc-055694	Macaca mulatta	99.02	0.00e+00	1387.00
IUUC-Mga-059523	Meleagris gallopavo	74.61	0.00e+00	1035.00
IUUC-Mmr-060885	Microcebus murinus	94.11	0.00e+00	1341.00
IUUC-Mdo-063018	Monodelphis domestica	79.75	0.00e+00	1124.00
IUUC-Mmu-064012	Mus musculus	79.94	0.00e+00	1094.00
IUUC-Mpu-066207	Mustela putorius furo	90.31	0.00e+00	1328.00
IUUC-Mlu-066929	Myotis lucifugus	86.77	0.00e+00	1187.00
IUUC-Nle-069313	Nomascus leucogenys	85.30	0.00e+00	1161.00
IUUC-Opr-070375	Ochotona princeps	82.63	0.00e+00	1122.00
IUUC-Ont-071637	Oreochromis niloticus	63.98	0.00e+00	861.00
IUUC-Oan-073030	Ornithorhynchus anatinus	78.83	0.00e+00	861.00
IUUC-Ocu-074836	Oryctolagus cuniculus	88.31	0.00e+00	1257.00
IUUC-Oga-088367	Otolemur garnettii	93.13	0.00e+00	1308.00
IUUC-Oar-089953	Ovis aries	91.02	0.00e+00	1318.00
IUUC-Ptr-090980	Pan troglodytes	95.51	0.00e+00	1342.00
IUUC-Psi-094078	Pelodiscus sinensis	76.17	0.00e+00	845.00
IUUC-Pab-098514	Pongo abelii	95.93	0.00e+00	1349.00
IUUC-Pva-102984	Pteropus vampyrus	89.33	0.00e+00	1250.00
IUUC-Rno-106019	Rattus norvegicus	80.03	0.00e+00	1134.00
IUUC-Sha-106965	Sarcophilus harrisii	78.37	0.00e+00	1116.00
IUUC-Ssc-115299	Sus scrofa	91.15	0.00e+00	1329.00
IUUC-Tgu-117160	Taeniopygia guttata	73.68	0.00e+00	1013.00
IUUC-Tru-118156	Takifugu rubripes	60.76	0.00e+00	835.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.21	0.00e+00	845.00
IUUC-Tbe-128084	Tupaia belangeri	85.53	0.00e+00	1205.00
IUUC-Ttr-128928	Tursiops truncatus	92.56	0.00e+00	1342.00
IUUC-Vpa-130706	Vicugna pacos	91.71	0.00e+00	1325.00
IUUC-Xtr-132061	Xenopus tropicalis	71.65	0.00e+00	922.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence