iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096520

Ensembl Protein ID

ENSPFOP00000008609.2

UniProt Accession

A0A087XS56; A0A087XS56_POEFO

Genbank Protein ID

ENSPFOP00000008609

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01022853

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000008113.2	ENSPFOT00000008621.2	ENSPFOP00000008609.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-118	396.5	1220	1553

Active Site

Position(s)	Description	Evidence
1521	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++++v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1220 DLQRSKFYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1305
           44567999**************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG nipV ++Nk+eY+++
   Q: 1306 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGGNIPVSEKNKKEYIER 1388
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1389 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRSNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1475
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs.snTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lPs ++TCfn+L+LP+Y+s + l++kLl+A+eet+ F+l+
   Q: 1476 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPSrAHTCFNRLDLPPYQSFSMLYDKLLTAVEETSTFGLE 1553
           ****************************************669********************************985 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

SNSSAHEHLL AVHRRAPHSR PYTVGLDNLS SLSVQITAGS SAGLGLQRAN SDTDLVTSES 60
RSSLTASTYQ LTLGQGHLVI SWDIKEEVDA TDWIGLYHID ETCVANVWES KNRGVNGTQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCAACAGCA GTGCCCACGA GCACCTGCTG GCGGTGCACC GCCGTGCTCC ACACAGTCGG 60
CCGTACACAG TGGGACTGGA CAACCTCAGC AGTTTGTCGG TACAGATAAC AGCGGGATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	66.94	0.00e+00	1990.00
IUUC-Apl-003935	Anas platyrhynchos	67.10	0.00e+00	2001.00
IUUC-Aca-004558	Anolis carolinensis	66.60	0.00e+00	1989.00
IUUC-Ame-010893	Astyanax mexicanus	90.73	0.00e+00	1322.00
IUUC-Bta-013093	Bos taurus	86.22	0.00e+00	1410.00
IUUC-Cja-019651	Callithrix jacchus	67.24	0.00e+00	1927.00
IUUC-Cfa-021232	Canis familiaris	87.89	0.00e+00	1445.00
IUUC-Cpo-021770	Cavia porcellus	87.83	0.00e+00	1469.00
IUUC-Csa-023970	Chlorocebus sabaeus	67.23	0.00e+00	1975.00
IUUC-Cho-024512	Choloepus hoffmanni	78.30	0.00e+00	1235.00
IUUC-Csv-026127	Ciona savignyi	66.25	7.00e-154	536.00
IUUC-Dre-028275	Danio rerio	85.37	0.00e+00	1493.00
IUUC-Dno-029963	Dasypus novemcinctus	66.67	0.00e+00	1906.00
IUUC-Dor-030282	Dipodomys ordii	53.39	0.00e+00	1050.00
IUUC-Dme-032217	Drosophila melanogaster	70.26	0.00e+00	649.00
IUUC-Ete-033132	Echinops telfairi	74.04	0.00e+00	1120.00
IUUC-Eca-033978	Equus caballus	65.96	0.00e+00	1961.00
IUUC-Fca-036157	Felis catus	65.96	0.00e+00	1970.00
IUUC-Fal-037110	Ficedula albicollis	85.96	0.00e+00	1449.00
IUUC-Gmo-039291	Gadus morhua	79.72	0.00e+00	1009.00
IUUC-Gga-040821	Gallus gallus	66.94	0.00e+00	2007.00
IUUC-Gac-042181	Gasterosteus aculeatus	78.41	0.00e+00	1527.00
IUUC-Ggo-044862	Gorilla gorilla	67.52	0.00e+00	1914.00
IUUC-Hsa-046219	Homo sapiens	67.44	0.00e+00	2008.00
IUUC-Lch-050526	Latimeria chalumnae	65.57	0.00e+00	1969.00
IUUC-Loc-052648	Lepisosteus oculatus	85.26	0.00e+00	1473.00
IUUC-Laf-054005	Loxodonta africana	66.65	0.00e+00	1993.00
IUUC-Mcc-055314	Macaca mulatta	66.65	0.00e+00	1973.00
IUUC-Meu-056356	Macropus eugenii	76.67	0.00e+00	753.00
IUUC-Mga-060074	Meleagris gallopavo	65.63	0.00e+00	1927.00
IUUC-Mmr-061526	Microcebus murinus	65.51	0.00e+00	1958.00
IUUC-Mdo-063017	Monodelphis domestica	66.58	0.00e+00	1964.00
IUUC-Mmu-064165	Mus musculus	65.72	0.00e+00	1958.00
IUUC-Mpu-065835	Mustela putorius furo	84.03	0.00e+00	1396.00
IUUC-Mlu-067709	Myotis lucifugus	64.77	0.00e+00	1912.00
IUUC-Nle-069308	Nomascus leucogenys	67.42	0.00e+00	1984.00
IUUC-Opr-070330	Ochotona princeps	56.23	0.00e+00	1547.00
IUUC-Ont-071345	Oreochromis niloticus	72.88	0.00e+00	2219.00
IUUC-Ocu-074775	Oryctolagus cuniculus	66.85	0.00e+00	1812.00
IUUC-Ola-087225	Oryzias latipes	84.79	0.00e+00	1348.00
IUUC-Oga-088177	Otolemur garnettii	87.83	0.00e+00	1448.00
IUUC-Oar-089452	Ovis aries	65.80	0.00e+00	1971.00
IUUC-Ptr-090806	Pan troglodytes	67.32	0.00e+00	1991.00
IUUC-Pan-091838	Papio anubis	67.24	0.00e+00	1900.00
IUUC-Psi-094090	Pelodiscus sinensis	66.17	0.00e+00	1944.00
IUUC-Pab-098405	Pongo abelii	67.30	0.00e+00	1988.00
IUUC-Pca-100441	Procavia capensis	56.80	0.00e+00	1359.00
IUUC-Pva-102324	Pteropus vampyrus	87.17	0.00e+00	1435.00
IUUC-Rno-105943	Rattus norvegicus	66.38	0.00e+00	1985.00
IUUC-Sha-106985	Sarcophilus harrisii	65.09	0.00e+00	1657.00
IUUC-Sar-113505	Sorex araneus	84.36	0.00e+00	1361.00
IUUC-Ssc-115439	Sus scrofa	54.94	0.00e+00	1046.00
IUUC-Tgu-117078	Taeniopygia guttata	85.64	0.00e+00	1446.00
IUUC-Tru-118671	Takifugu rubripes	76.01	0.00e+00	2262.00
IUUC-Tsy-119379	Tarsius syrichta	70.18	0.00e+00	670.00
IUUC-Tni-120619	Tetraodon nigroviridis	91.72	0.00e+00	1503.00
IUUC-Ttr-128469	Tursiops truncatus	61.93	0.00e+00	1738.00
IUUC-Vpa-130498	Vicugna pacos	57.50	0.00e+00	1572.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence