iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007959

Ensembl Protein ID

AAS53378

UniProt Accession

Q754R5; UBP4_ASHGO

Genbank Protein ID

AAS53378.2

Protein Name

Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4

Genbank Nucleotide ID

AE016819

Gene Name

DOA4; UBP4; AFR007W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AFR007W	AAS53378	AAS53378

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.80e-87	289.4	488	848

Active Site

Position(s)	Description	Evidence
497	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
806	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw..........kskkkavsprellkalkkeaeefsgyeqq 90
           +Gl N gN+CYm +++QcL+ ++el  ++l+ ++++++n +++ ++kg l++ + +l+++++           ++k+av p++++ a+++++++f+ + qq
   Q: 488  VGLVNCGNSCYMSCIIQCLLGTQELCTMFLNnSYQNHINLNSRLGSKGLLARYFSQLIHQMYqygkdirkkmGNEKTAVIPTQFKIACGSINSSFKDNTQQ 588
           6*****************************9999***************************6555555555578888************************ PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsde.........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
           D+qEf++flld+l+e+l++  n+p  +e +e+ +++ ++         ++e+  +   s+i+dlFqgq+ sq++c+ c+++s++++pf  ls+pvp+ +++
   Q: 589  DCQEFCQFLLDGLHEDLNQCGNNPPLKELSEEAEKMREMmpmrlasaiEWERYLTTDFSVIVDLFQGQYASQLQCKVCQRTSTTYQPFSVLSVPVPSTRTC 689
           *******************88888888888888888888899*********************************************************99 PP
   S: 183  kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke......... 274
              +l+dc+ +ftk e+le+e++++c++ckk+q ++kk+++++lP+ Li+hLkRf      ++ +k+n  v++p  Ldl+ f +++ +k+ +         
   Q: 690  ---TLTDCFTEFTKIETLEQEEQWSCPSCKKRQPSTKKITITRLPRNLIIHLKRF-----DNMLNKNNVFVSYPSVLDLTAFWANDYDKKVTnnnvelpsr 782
           ...****************************************************.....57899****************98884444333566777777 PP
   S: 275  ....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevk.eeevleetgstaYvlfYkr 337
               + +Y+L+++ +H G+l+ GHY+ayv++     W+++dD++ ++++   e  +   ++aYvlfY+r
   Q: 783  gqvpPFNYQLYGIACHDGTLRAGHYTAYVNKGAVLgWCYYDDTNWRQIRsAREYIT---QNAYVLFYHR 848
           7777*************************9954447************62577777...9*******97 PP

Organism

Ashbya gossypii

Functional Description
(View)

Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Required for promoting coordination of DNA replication and avoids DNA overreplication (By similarity).

Protein Sequence
(Fasta)

MPHIQESRVW CRSISQLSHL AEQFVTENGT ESTDMKLLLQ QCVDTLSNYQ DECKKIKSVS 60
KPVPSKELYD LYETAYVYFK IVSLIVLNKI PKLEEYARAK SDAVDRTGKQ LLEIYNMLVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCATA TTCAGGAAAG CAGGGTCTGG TGCAGGTCCA TCAGCCAGCT CTCCCATCTC 60
GCTGAACAAT TTGTCACTGA GAATGGAACT GAAAGCACGG ACATGAAACT GTTGCTCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH

SMART

SM00450--RHOD

Gene Ontology

GO:0031902--C:late endosome membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ago:AGOS_AFR007W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	35.62	4.00e-55	207.00
IUUC-Apl-003226	Anas platyrhynchos	35.81	3.00e-56	211.00
IUUC-Aca-004936	Anolis carolinensis	34.16	9.00e-52	196.00
IUUC-Acl-008102	Aspergillus clavatus	34.92	5.00e-64	237.00
IUUC-Afl-008604	Aspergillus flavus	35.53	8.00e-65	239.00
IUUC-Afu-009001	Aspergillus fumigatus	34.58	5.00e-63	234.00
IUUC-Ani-009291	Aspergillus nidulans	32.36	2.00e-59	222.00
IUUC-Ang-009844	Aspergillus niger	35.22	7.00e-65	239.00
IUUC-Aor-010098	Aspergillus oryzae	35.34	8.00e-65	239.00
IUUC-Ate-010585	Aspergillus terreus	34.13	2.00e-62	231.00
IUUC-Ame-011102	Astyanax mexicanus	33.60	5.00e-44	169.00
IUUC-Bta-013008	Bos taurus	35.54	6.00e-56	210.00
IUUC-Cel-018482	Caenorhabditis elegans	27.97	1.00e-38	152.00
IUUC-Cja-019173	Callithrix jacchus	35.26	2.00e-55	208.00
IUUC-Cfa-021243	Canis familiaris	35.62	3.00e-55	208.00
IUUC-Cpo-021522	Cavia porcellus	35.54	2.00e-55	209.00
IUUC-Csa-023616	Chlorocebus sabaeus	35.54	3.00e-55	207.00
IUUC-Cin-025797	Ciona intestinalis	37.10	3.00e-55	206.00
IUUC-Csv-026253	Ciona savignyi	30.53	1.00e-38	153.00
IUUC-Cne-026821	Cryptococcus neoformans	39.36	3.00e-71	261.00
IUUC-Dre-028440	Danio rerio	33.61	3.00e-50	191.00
IUUC-Dno-029039	Dasypus novemcinctus	35.62	2.00e-55	208.00
IUUC-Dor-031053	Dipodomys ordii	31.50	8.00e-45	172.00
IUUC-Dse-031463	Dothistroma septosporum	32.32	2.00e-56	211.00
IUUC-Dme-032208	Drosophila melanogaster	33.24	8.00e-45	173.00
IUUC-Ete-033040	Echinops telfairi	38.58	6.00e-46	177.00
IUUC-Eca-033449	Equus caballus	35.62	3.00e-56	211.00
IUUC-Fca-035794	Felis catus	35.26	4.00e-54	203.00
IUUC-Fal-037322	Ficedula albicollis	34.99	1.00e-54	206.00
IUUC-Gmo-038584	Gadus morhua	33.95	2.00e-49	188.00
IUUC-Gga-041188	Gallus gallus	36.09	1.00e-55	209.00
IUUC-Gac-041850	Gasterosteus aculeatus	34.75	5.00e-53	201.00
IUUC-Ggo-045565	Gorilla gorilla	35.62	2.00e-55	208.00
IUUC-Hsa-046438	Homo sapiens	35.62	3.00e-55	208.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	35.62	3.00e-55	208.00
IUUC-Kpa-049321	Komagataella pastoris	47.43	2.00e-98	350.00
IUUC-Lch-050485	Latimeria chalumnae	35.81	1.00e-54	206.00
IUUC-Loc-052769	Lepisosteus oculatus	34.71	2.00e-52	199.00
IUUC-Lma-053021	Leptosphaeria maculans	35.16	8.00e-65	240.00
IUUC-Laf-053432	Loxodonta africana	35.81	1.00e-55	209.00
IUUC-Mcc-055823	Macaca mulatta	35.89	1.00e-55	209.00
IUUC-Meu-056279	Macropus eugenii	30.65	3.00e-45	174.00
IUUC-Mla-059089	Melampsora laricipopulina	39.82	1.00e-60	226.00
IUUC-Mga-059739	Meleagris gallopavo	35.62	4.00e-55	207.00
IUUC-Mvi-060559	Microbotryum violaceum	36.61	9.00e-62	229.00
IUUC-Mmr-061158	Microcebus murinus	35.26	5.00e-55	207.00
IUUC-Mdo-061801	Monodelphis domestica	35.54	3.00e-55	208.00
IUUC-Mmu-063665	Mus musculus	35.26	5.00e-56	210.00
IUUC-Mpu-066738	Mustela putorius furo	35.62	3.00e-55	208.00
IUUC-Mlu-067307	Myotis lucifugus	35.62	4.00e-55	207.00
IUUC-Nfi-068410	Neosartorya fischeri	34.58	2.00e-62	232.00
IUUC-Nle-069314	Nomascus leucogenys	35.62	5.00e-55	207.00
IUUC-Opr-070907	Ochotona princeps	33.69	4.00e-42	164.00
IUUC-Ont-071545	Oreochromis niloticus	36.07	6.00e-55	207.00
IUUC-Oan-073537	Ornithorhynchus anatinus	35.69	2.00e-53	202.00
IUUC-Ocu-074193	Oryctolagus cuniculus	35.62	2.00e-55	209.00
IUUC-Ola-086622	Oryzias latipes	35.54	4.00e-54	204.00
IUUC-Oga-088271	Otolemur garnettii	35.26	2.00e-55	209.00
IUUC-Oar-090431	Ovis aries	35.54	7.00e-56	210.00
IUUC-Ptr-091339	Pan troglodytes	35.62	2.00e-55	209.00
IUUC-Pan-092266	Papio anubis	34.16	2.00e-48	183.00
IUUC-Psi-093216	Pelodiscus sinensis	32.04	6.00e-47	180.00
IUUC-Pma-094626	Petromyzon marinus	33.88	2.00e-52	197.00
IUUC-Pno-094986	Phaeosphaeria nodorum	34.71	2.00e-50	192.00
IUUC-Pfo-096463	Poecilia formosa	34.48	3.00e-53	201.00
IUUC-Pab-097645	Pongo abelii	35.62	3.00e-55	208.00
IUUC-Pca-100205	Procavia capensis	32.87	4.00e-39	153.00
IUUC-Pva-103222	Pteropus vampyrus	34.25	1.00e-51	196.00
IUUC-Pgr-103408	Puccinia graminis	33.70	1.00e-45	176.00
IUUC-Ptt-103699	Puccinia triticina	43.82	8.00e-58	217.00
IUUC-Pte-104348	Pyrenophora teres	34.40	1.00e-53	202.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	33.76	4.00e-62	231.00
IUUC-Rno-105510	Rattus norvegicus	34.99	8.00e-55	206.00
IUUC-Sce-106166	Saccharomyces cerevisiae	57.14	2.00e-155	540.00
IUUC-Sha-106879	Sarcophilus harrisii	35.52	7.00e-54	203.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	35.77	2.00e-58	217.00
IUUC-Spo-108065	Schizosaccharomyces pombe	32.10	3.00e-52	197.00
IUUC-Smo-108711	Selaginella moellendorffii	29.43	7.00e-34	135.00
IUUC-Sar-113019	Sorex araneus	35.26	1.00e-55	209.00
IUUC-Sre-115031	Sporisorium reilianum	38.27	1.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	35.62	4.00e-55	207.00
IUUC-Tgu-117062	Taeniopygia guttata	34.99	2.00e-54	205.00
IUUC-Tru-117908	Takifugu rubripes	35.54	2.00e-53	202.00
IUUC-Tsy-118867	Tarsius syrichta	31.13	1.00e-42	166.00
IUUC-Tni-120206	Tetraodon nigroviridis	35.60	4.00e-51	194.00
IUUC-Tme-127144	Tuber melanosporum	43.75	7.00e-84	303.00
IUUC-Ttr-128580	Tursiops truncatus	35.81	6.00e-56	210.00
IUUC-Uma-129340	Ustilago maydis	37.57	3.00e-66	245.00
IUUC-Vpa-130541	Vicugna pacos	34.25	2.00e-50	192.00
IUUC-Xtr-132161	Xenopus tropicalis	36.71	5.00e-59	220.00
IUUC-Xma-134271	Xiphophorus maculatus	34.48	3.00e-53	201.00
IUUC-Yli-134561	Yarrowia lipolytica	41.94	1.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence