iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025427.14	ENSMUST00000026494.13	ENSMUSP00000026494.6
ENSMUSG00000025427.14	ENSMUST00000182153.1	ENSMUSP00000138276.1
ENSMUSG00000025427.14	ENSMUST00000182146.1	ENSMUSP00000138529.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-07	32.0	295	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl++++dg  ++ lpC H+fh+ C+ +w         + +CP+Cr
   Q: 295  CTICLSMLEDGedVRRLPCMHLFHQLCVDQW------LAMSKKCPICR 336
           ********66555******************......999999****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558).

Protein Sequence
(Fasta)

MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS 60
QPGLSAHMAP AHQHSGTLHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAAGGGCC CGCGCGCAGC CGCCGCCGCT GCGCGAGGAG CCAGGATGGT CCTGGTCCAC 60
GTCGGCTATC TCGTGCTTCC AGTGTTTGGC TCTGTGCGAA ACAGAGGTAT CGCTTTTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007409--P:axonogenesis
GO:0035136--P:forelimb morphogenesis
GO:0060384--P:innervation
GO:0060173--P:limb development
GO:0008045--P:motor neuron axon guidance
GO:0010259--P:multicellular organism aging
GO:0061061--P:muscle structure development
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030163--P:protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:225743

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000618	Aegilops tauschii	37.04	2.00e-14	74.70
IUUC-Aml-001791	Ailuropoda melanoleuca	98.54	4.00e-178	617.00
IUUC-Atr-003149	Amborella trichopoda	52.54	4.00e-16	76.30
IUUC-Apl-003783	Anas platyrhynchos	68.99	3.00e-121	427.00
IUUC-Aca-005299	Anolis carolinensis	85.23	3.00e-140	491.00
IUUC-Aly-005415	Arabidopsis lyrata	36.63	1.00e-16	80.10
IUUC-Ame-011948	Astyanax mexicanus	70.62	5.00e-129	454.00
IUUC-Bta-012470	Bos taurus	95.25	6.00e-167	579.00
IUUC-Bdi-014014	Brachypodium distachyon	37.07	1.00e-15	77.40
IUUC-Bol-016611	Brassica oleracea	36.11	7.00e-14	72.00
IUUC-Cel-018118	Caenorhabditis elegans	41.18	9.00e-16	78.20
IUUC-Cja-019798	Callithrix jacchus	94.24	2.00e-175	607.00
IUUC-Cfa-020297	Canis familiaris	97.69	1.00e-179	622.00
IUUC-Cpo-022225	Cavia porcellus	97.05	1.00e-179	622.00
IUUC-Csa-024018	Chlorocebus sabaeus	98.47	2.00e-174	604.00
IUUC-Cne-026985	Cryptococcus neoformans	39.05	2.00e-10	61.60
IUUC-Cme-027312	Cyanidioschyzon merolae	49.23	5.00e-13	68.60
IUUC-Dre-028365	Danio rerio	68.69	4.00e-104	370.00
IUUC-Dno-029962	Dasypus novemcinctus	94.63	1.00e-154	538.00
IUUC-Dor-030727	Dipodomys ordii	96.83	3.00e-180	624.00
IUUC-Eca-033911	Equus caballus	98.17	5.00e-169	586.00
IUUC-Fca-035641	Felis catus	98.25	8.00e-179	619.00
IUUC-Fal-037200	Ficedula albicollis	85.54	2.00e-143	501.00
IUUC-Gmo-039613	Gadus morhua	77.09	1.00e-86	312.00
IUUC-Gga-040277	Gallus gallus	86.67	8.00e-125	439.00
IUUC-Gac-042544	Gasterosteus aculeatus	63.20	8.00e-115	406.00
IUUC-Gma-044396	Glycine max	39.39	2.00e-15	77.80
IUUC-Ggo-044631	Gorilla gorilla	88.18	2.00e-176	610.00
IUUC-Hsa-046864	Homo sapiens	98.56	0.00e+00	645.00
IUUC-Hvu-047447	Hordeum vulgare	36.79	8.00e-15	74.70
IUUC-Itr-048602	Ictidomys tridecemlineatus	98.47	5.00e-176	609.00
IUUC-Lch-049656	Latimeria chalumnae	72.80	8.00e-110	390.00
IUUC-Lpe-050720	Leersia perrieri	34.34	7.00e-15	75.10
IUUC-Loc-052046	Lepisosteus oculatus	78.12	7.00e-144	503.00
IUUC-Laf-053554	Loxodonta africana	98.05	2.00e-83	301.00
IUUC-Mcc-055198	Macaca mulatta	98.47	2.00e-174	604.00
IUUC-Meu-055988	Macropus eugenii	83.44	2.00e-123	434.00
IUUC-Mtr-057649	Medicago truncatula	36.36	5.00e-14	73.20
IUUC-Mga-059245	Meleagris gallopavo	88.31	8.00e-75	271.00
IUUC-Mmr-061389	Microcebus murinus	98.56	4.00e-176	610.00
IUUC-Mdo-062317	Monodelphis domestica	94.80	4.00e-151	527.00
IUUC-Mac-065469	Musa acuminata	35.71	3.00e-15	76.30
IUUC-Mpu-066793	Mustela putorius furo	97.01	2.00e-165	575.00
IUUC-Nle-069235	Nomascus leucogenys	98.56	0.00e+00	642.00
IUUC-Opr-070646	Ochotona princeps	97.55	4.00e-162	563.00
IUUC-Ont-072005	Oreochromis niloticus	72.03	2.00e-119	422.00
IUUC-Oan-072924	Ornithorhynchus anatinus	76.42	3.00e-115	407.00
IUUC-Ocu-074718	Oryctolagus cuniculus	97.41	0.00e+00	639.00
IUUC-Oba-075466	Oryza barthii	33.33	4.00e-15	75.90
IUUC-Obr-076189	Oryza brachyantha	37.50	2.00e-14	73.60
IUUC-Ogl-076994	Oryza glaberrima	33.33	4.00e-15	75.90
IUUC-Ogu-078200	Oryza glumaepatula	33.33	4.00e-15	75.90
IUUC-Oin-079508	Oryza indica	33.33	4.00e-15	75.90
IUUC-Olo-080855	Oryza longistaminata	33.33	4.00e-15	75.90
IUUC-Ome-081841	Oryza meridionalis	33.33	4.00e-15	75.90
IUUC-Oni-082470	Oryza nivara	33.33	5.00e-15	75.50
IUUC-Oru-085181	Oryza rufipogon	33.33	4.00e-15	75.90
IUUC-Osa-086143	Oryza sativa	33.33	4.00e-15	75.90
IUUC-Ola-087143	Oryzias latipes	72.07	4.00e-120	424.00
IUUC-Olu-087774	Ostreococcus lucimarinus	42.59	6.00e-13	65.90
IUUC-Oga-087993	Otolemur garnettii	99.14	0.00e+00	653.00
IUUC-Oar-089588	Ovis aries	95.72	2.00e-163	567.00
IUUC-Ptr-091341	Pan troglodytes	98.56	0.00e+00	645.00
IUUC-Pan-091775	Papio anubis	98.56	0.00e+00	645.00
IUUC-Psi-092966	Pelodiscus sinensis	85.23	1.00e-137	482.00
IUUC-Ppa-095313	Physcomitrella patens	35.35	3.00e-14	74.30
IUUC-Pfo-096103	Poecilia formosa	68.84	1.00e-110	392.00
IUUC-Pop-099945	Populus trichocarpa	42.42	6.00e-15	76.30
IUUC-Ppe-101513	Prunus persica	40.40	4.00e-15	76.60
IUUC-Pva-102801	Pteropus vampyrus	92.80	9.00e-171	592.00
IUUC-Rno-105973	Rattus norvegicus	97.34	1.00e-177	615.00
IUUC-Sha-107027	Sarcophilus harrisii	91.28	3.00e-153	534.00
IUUC-Sja-107932	Schizosaccharomyces japonicus	50.98	4.00e-12	66.20
IUUC-Spo-108030	Schizosaccharomyces pombe	50.98	5.00e-11	62.80
IUUC-Smo-108847	Selaginella moellendorffii	34.29	2.00e-14	73.90
IUUC-Sit-110501	Setaria italica	34.29	1.00e-15	77.40
IUUC-Sly-111039	Solanum lycopersicum	41.41	7.00e-16	79.30
IUUC-Stu-112006	Solanum tuberosum	37.08	3.00e-11	63.90
IUUC-Sar-113383	Sorex araneus	96.32	7.00e-160	556.00
IUUC-Sbi-113906	Sorghum bicolor	58.33	8.00e-16	77.40
IUUC-Ssc-116357	Sus scrofa	88.86	9.00e-148	516.00
IUUC-Tgu-117345	Taeniopygia guttata	84.94	1.00e-142	499.00
IUUC-Tru-118756	Takifugu rubripes	70.59	1.00e-121	429.00
IUUC-Tni-120423	Tetraodon nigroviridis	69.38	3.00e-113	401.00
IUUC-Tca-121420	Theobroma cacao	37.37	2.00e-14	74.70
IUUC-Vpa-130177	Vicugna pacos	98.37	2.00e-101	360.00
IUUC-Vvi-130983	Vitis vinifera	34.65	5.00e-08	51.20
IUUC-Xtr-132317	Xenopus tropicalis	76.26	6.00e-116	410.00
IUUC-Xma-133967	Xiphophorus maculatus	69.77	6.00e-110	390.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence