iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026596.13	ENSMUST00000173929.7	ENSMUSP00000133381.1
ENSMUSG00000026596.13	ENSMUST00000166172.8	ENSMUSP00000126181.2
ENSMUSG00000026596.13	ENSMUST00000027888.12	ENSMUSP00000027888.6
ENSMUSG00000026596.13	ENSMUST00000190749.1	ENSMUSP00000140125.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-12	46.8	109	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 109  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 166
           67899************************.*********98..788899*********997 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TADAGFNVFT QHDHFASCVE 60
DGFEGDKTGG SSPEVLHRPF GCDAESQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTGCTCGG TGGTTTAAAG ATGGCGGCGG CGGCTGGGGC GAGGAGCCGC CGGAGGGGGA 60
GGGAGAAGGA GAGTCTGTGA GTCGCTGGGA GGCAGCGCGG CAGCGGCTCC GAGGAGTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0071300--P:cellular response to retinoic acid
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	93.97	0.00e+00	1892.00
IUUC-Apl-003389	Anas platyrhynchos	83.86	0.00e+00	1677.00
IUUC-Ame-010629	Astyanax mexicanus	58.43	0.00e+00	1049.00
IUUC-Bta-013370	Bos taurus	93.50	0.00e+00	2001.00
IUUC-Cja-018894	Callithrix jacchus	92.47	0.00e+00	1901.00
IUUC-Cfa-020398	Canis familiaris	95.91	0.00e+00	1222.00
IUUC-Cpo-022367	Cavia porcellus	92.56	0.00e+00	1450.00
IUUC-Csa-023386	Chlorocebus sabaeus	94.15	0.00e+00	1884.00
IUUC-Cho-024714	Choloepus hoffmanni	94.73	0.00e+00	1340.00
IUUC-Dre-027741	Danio rerio	66.67	0.00e+00	1362.00
IUUC-Dno-029246	Dasypus novemcinctus	90.54	0.00e+00	1904.00
IUUC-Dor-030416	Dipodomys ordii	87.08	0.00e+00	1784.00
IUUC-Ete-032899	Echinops telfairi	74.42	0.00e+00	777.00
IUUC-Eca-033387	Equus caballus	92.91	0.00e+00	1893.00
IUUC-Eeu-035058	Erinaceus europaeus	83.38	0.00e+00	1776.00
IUUC-Fca-036578	Felis catus	87.83	0.00e+00	1712.00
IUUC-Fal-037491	Ficedula albicollis	86.59	0.00e+00	1801.00
IUUC-Gmo-038509	Gadus morhua	77.26	0.00e+00	1117.00
IUUC-Gga-040638	Gallus gallus	84.27	0.00e+00	1749.00
IUUC-Gac-042550	Gasterosteus aculeatus	67.50	0.00e+00	1292.00
IUUC-Ggo-044487	Gorilla gorilla	94.34	0.00e+00	1982.00
IUUC-Hsa-046636	Homo sapiens	94.26	0.00e+00	1982.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	94.52	0.00e+00	1928.00
IUUC-Lch-049530	Latimeria chalumnae	74.11	0.00e+00	1542.00
IUUC-Loc-051933	Lepisosteus oculatus	70.07	0.00e+00	1413.00
IUUC-Laf-053802	Loxodonta africana	94.01	0.00e+00	2045.00
IUUC-Mcc-054836	Macaca mulatta	94.09	0.00e+00	1986.00
IUUC-Mga-059277	Meleagris gallopavo	86.31	0.00e+00	1761.00
IUUC-Mmr-061206	Microcebus murinus	92.65	0.00e+00	1975.00
IUUC-Mdo-062281	Monodelphis domestica	92.44	0.00e+00	1211.00
IUUC-Mpu-066309	Mustela putorius furo	95.20	0.00e+00	1317.00
IUUC-Mlu-068070	Myotis lucifugus	93.52	0.00e+00	1885.00
IUUC-Nle-070062	Nomascus leucogenys	95.49	0.00e+00	1274.00
IUUC-Opr-070534	Ochotona princeps	87.42	0.00e+00	974.00
IUUC-Ont-072440	Oreochromis niloticus	67.95	0.00e+00	1243.00
IUUC-Oan-073526	Ornithorhynchus anatinus	87.04	0.00e+00	1694.00
IUUC-Ocu-074051	Oryctolagus cuniculus	93.43	0.00e+00	1788.00
IUUC-Oin-079172	Oryza indica	34.39	2.00e-23	104.00
IUUC-Olo-080286	Oryza longistaminata	34.39	2.00e-23	104.00
IUUC-Opu-083538	Oryza punctata	34.84	3.00e-23	103.00
IUUC-Oru-084741	Oryza rufipogon	34.39	2.00e-23	104.00
IUUC-Osa-085779	Oryza sativa	34.39	2.00e-23	104.00
IUUC-Ola-086752	Oryzias latipes	95.04	0.00e+00	910.00
IUUC-Oga-088767	Otolemur garnettii	86.71	0.00e+00	1679.00
IUUC-Oar-089800	Ovis aries	93.62	0.00e+00	1900.00
IUUC-Ptr-090857	Pan troglodytes	95.49	0.00e+00	1273.00
IUUC-Pan-092279	Papio anubis	92.31	0.00e+00	1918.00
IUUC-Psi-093573	Pelodiscus sinensis	87.26	0.00e+00	1742.00
IUUC-Pfo-096543	Poecilia formosa	71.71	0.00e+00	1144.00
IUUC-Pab-097949	Pongo abelii	91.39	0.00e+00	1886.00
IUUC-Pca-100370	Procavia capensis	91.32	0.00e+00	1361.00
IUUC-Pva-103220	Pteropus vampyrus	83.54	0.00e+00	1689.00
IUUC-Rno-105924	Rattus norvegicus	94.33	0.00e+00	1984.00
IUUC-Sha-107114	Sarcophilus harrisii	85.43	0.00e+00	1340.00
IUUC-Ssc-115968	Sus scrofa	93.07	0.00e+00	2032.00
IUUC-Tgu-117301	Taeniopygia guttata	86.33	0.00e+00	1723.00
IUUC-Tru-118410	Takifugu rubripes	66.59	0.00e+00	1387.00
IUUC-Tni-119991	Tetraodon nigroviridis	70.73	0.00e+00	1268.00
IUUC-Tbe-127362	Tupaia belangeri	89.19	0.00e+00	1811.00
IUUC-Ttr-129291	Tursiops truncatus	93.43	0.00e+00	1872.00
IUUC-Vpa-130800	Vicugna pacos	92.16	0.00e+00	1450.00
IUUC-Xtr-132965	Xenopus tropicalis	71.67	0.00e+00	1272.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence