iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028271

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin protein ligase E3B

Genbank Nucleotide ID

BX510366

Gene Name

ube3b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000061960.6	ENSDART00000088968.5	ENSDARP00000083401.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-112	376.2	706	1069

Active Site

Position(s)	Description	Evidence
1037	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdg 85
           ++k +++v+fv+     E+g+d++Gv++efl++++k+++np l+lf+++++++  l+p+p+s +++ +hl+lFef+G++lgka+++g
   Q: 706  SIKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNE-RLYPSPTSSIHE-NHLQLFEFVGKMLGKAMYEG 790
           578899****************************************9888655.569******976.******************** PP
   S: 86   rlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
            ++d+p++++f++++lg+       s+++l+++d+e+yk+l++ik++ + d+++lgl+l++  +ee++g+  ++eL+pgG+++pVtn
   Q: 791  IVVDVPFASFFLSQVLGHhhstfYSSIDELPSLDSEFYKNLTSIKRY-DGDVSDLGLTLSY--DEEVMGQLVCHELIPGGKTMPVTN 874
           ******************777777999********************.6799998777776..5999******************** PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevl 253
           eNk +Y++l++++r++++ikeq++af +Gf+++i++e+l +F++ e++ li+G+ +eid++dlkk+t y gg+++++++i w+w++l
   Q: 875  ENKISYIHLMAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDnAEIDLDDLKKHTVYYGGFHSSHRVILWLWDIL 961
           ******************************************************9******************************** PP
   S: 254  .eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeYss 315
            ++f+ +er++fL+FvT++sr Pl Gfa+lk                        + +f+irk++   rlP+s+TCfn+LkLP+Ys+
   Q: 962  sSDFTPDERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSK 1048
           999************************************************************9999******************** PP
   S: 316  keilkekLlyAieetkgFels 336
           k+il++kL+yAi++++gFels
   Q: 1049 KSILRDKLRYAISMNTGFELS 1069
           ******************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MFTATQTSKT QFLDKARVAR EERKGHKEKE RAATQIQALV RRFLCRCRLQ KEIRKEVDDF 60
IAVSDAGPTK RNALSIFKIA RKLLFILSKD DKLRFEKLCR IILNSMDVEN EPKVWYVSLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCGTTAAT GGATTAGAGC TGCGGTGTCT GGGTCGCTCT TTTGTTTACA TCAGTTTTCC 60
TTTTATTCTC AAACGCTCAG GTAAATGAAA CATCTGTGAA AACCTTTAAT ACTTTCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:556864

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	40.14	3.00e-109	390.00
IUUC-Aml-002107	Ailuropoda melanoleuca	81.68	0.00e+00	1790.00
IUUC-Atr-003017	Amborella trichopoda	39.89	1.00e-114	408.00
IUUC-Apl-003328	Anas platyrhynchos	84.75	0.00e+00	1783.00
IUUC-Aly-005794	Arabidopsis lyrata	39.82	1.00e-110	394.00
IUUC-Ath-007269	Arabidopsis thaliana	40.36	9.00e-114	405.00
IUUC-Bta-013547	Bos taurus	80.93	0.00e+00	1808.00
IUUC-Bdi-014502	Brachypodium distachyon	39.86	4.00e-113	403.00
IUUC-Bol-015093	Brassica oleracea	40.71	1.00e-114	408.00
IUUC-Bra-016722	Brassica rapa	40.71	3.00e-115	410.00
IUUC-Cel-018447	Caenorhabditis elegans	39.26	0.00e+00	672.00
IUUC-Cja-019855	Callithrix jacchus	81.59	0.00e+00	1793.00
IUUC-Cfa-020066	Canis familiaris	81.49	0.00e+00	1769.00
IUUC-Cpo-021504	Cavia porcellus	81.50	0.00e+00	1820.00
IUUC-Csa-023579	Chlorocebus sabaeus	81.50	0.00e+00	1788.00
IUUC-Cho-024430	Choloepus hoffmanni	70.79	0.00e+00	1280.00
IUUC-Cin-025750	Ciona intestinalis	45.75	0.00e+00	943.00
IUUC-Csv-026016	Ciona savignyi	46.83	0.00e+00	986.00
IUUC-Dno-029054	Dasypus novemcinctus	82.06	0.00e+00	1802.00
IUUC-Dor-030938	Dipodomys ordii	86.25	0.00e+00	1109.00
IUUC-Dme-031602	Drosophila melanogaster	48.07	0.00e+00	952.00
IUUC-Ete-033041	Echinops telfairi	79.12	0.00e+00	869.00
IUUC-Eca-034411	Equus caballus	81.87	0.00e+00	1775.00
IUUC-Eeu-035201	Erinaceus europaeus	76.94	0.00e+00	748.00
IUUC-Fca-036594	Felis catus	80.65	0.00e+00	1755.00
IUUC-Fal-037317	Ficedula albicollis	81.70	0.00e+00	1803.00
IUUC-Gmo-039412	Gadus morhua	87.14	0.00e+00	1910.00
IUUC-Gga-040149	Gallus gallus	85.14	0.00e+00	1833.00
IUUC-Gac-042088	Gasterosteus aculeatus	89.74	0.00e+00	1977.00
IUUC-Gma-042728	Glycine max	41.39	2.00e-114	407.00
IUUC-Ggo-045279	Gorilla gorilla	81.50	0.00e+00	1787.00
IUUC-Hsa-045660	Homo sapiens	81.31	0.00e+00	1784.00
IUUC-Hvu-047102	Hordeum vulgare	40.14	3.00e-108	386.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	73.54	0.00e+00	842.00
IUUC-Lch-050664	Latimeria chalumnae	85.81	0.00e+00	1878.00
IUUC-Lpe-050755	Leersia perrieri	37.66	2.00e-100	360.00
IUUC-Loc-052791	Lepisosteus oculatus	90.97	0.00e+00	1932.00
IUUC-Laf-053902	Loxodonta africana	82.43	0.00e+00	1807.00
IUUC-Mcc-054730	Macaca mulatta	81.40	0.00e+00	1788.00
IUUC-Meu-056527	Macropus eugenii	76.31	0.00e+00	1622.00
IUUC-Mtr-057671	Medicago truncatula	40.67	7.00e-114	405.00
IUUC-Mga-059260	Meleagris gallopavo	85.17	0.00e+00	1837.00
IUUC-Mmr-060804	Microcebus murinus	80.93	0.00e+00	1742.00
IUUC-Mdo-062575	Monodelphis domestica	80.21	0.00e+00	1724.00
IUUC-Mmu-063636	Mus musculus	79.53	0.00e+00	1714.00
IUUC-Mac-064989	Musa acuminata	39.47	2.00e-109	390.00
IUUC-Mpu-066677	Mustela putorius furo	80.93	0.00e+00	1670.00
IUUC-Mlu-067952	Myotis lucifugus	81.87	0.00e+00	1739.00
IUUC-Nle-069153	Nomascus leucogenys	81.40	0.00e+00	1787.00
IUUC-Opr-070554	Ochotona princeps	82.12	0.00e+00	1657.00
IUUC-Ont-071372	Oreochromis niloticus	91.02	0.00e+00	1962.00
IUUC-Oan-073327	Ornithorhynchus anatinus	68.94	0.00e+00	726.00
IUUC-Ocu-074183	Oryctolagus cuniculus	80.09	0.00e+00	1767.00
IUUC-Oba-075213	Oryza barthii	39.21	3.00e-109	390.00
IUUC-Obr-076320	Oryza brachyantha	39.55	5.00e-112	399.00
IUUC-Ogl-077093	Oryza glaberrima	39.55	6.00e-112	399.00
IUUC-Ogu-078947	Oryza glumaepatula	38.07	6.00e-113	402.00
IUUC-Oin-080058	Oryza indica	39.55	2.00e-111	397.00
IUUC-Olo-080742	Oryza longistaminata	39.38	3.00e-111	397.00
IUUC-Ome-081741	Oryza meridionalis	39.16	2.00e-104	374.00
IUUC-Oni-082385	Oryza nivara	38.07	5.00e-113	402.00
IUUC-Opu-083529	Oryza punctata	39.55	1.00e-111	398.00
IUUC-Oru-085128	Oryza rufipogon	37.01	2.00e-98	354.00
IUUC-Osa-085557	Oryza sativa	39.55	3.00e-111	396.00
IUUC-Ola-087337	Oryzias latipes	90.36	0.00e+00	1901.00
IUUC-Oga-088342	Otolemur garnettii	80.67	0.00e+00	1714.00
IUUC-Oar-090234	Ovis aries	80.36	0.00e+00	1778.00
IUUC-Ptr-091661	Pan troglodytes	81.50	0.00e+00	1787.00
IUUC-Pan-092728	Papio anubis	81.23	0.00e+00	1785.00
IUUC-Psi-093251	Pelodiscus sinensis	84.61	0.00e+00	1696.00
IUUC-Pma-094195	Petromyzon marinus	69.94	0.00e+00	1454.00
IUUC-Ppa-095544	Physcomitrella patens	38.20	5.00e-112	399.00
IUUC-Pfo-097472	Poecilia formosa	91.49	0.00e+00	1976.00
IUUC-Pab-098570	Pongo abelii	81.59	0.00e+00	1784.00
IUUC-Pca-100110	Procavia capensis	71.31	0.00e+00	1494.00
IUUC-Ppe-101281	Prunus persica	39.89	1.00e-109	391.00
IUUC-Pva-102887	Pteropus vampyrus	76.84	0.00e+00	1648.00
IUUC-Rno-106028	Rattus norvegicus	77.22	0.00e+00	1630.00
IUUC-Sha-107331	Sarcophilus harrisii	81.16	0.00e+00	1750.00
IUUC-Smo-109488	Selaginella moellendorffii	38.32	9.00e-109	388.00
IUUC-Sit-109811	Setaria italica	39.96	1.00e-111	397.00
IUUC-Sly-111013	Solanum lycopersicum	39.33	4.00e-103	369.00
IUUC-Sar-113287	Sorex araneus	65.97	9.00e-160	557.00
IUUC-Sbi-114433	Sorghum bicolor	39.90	1.00e-112	401.00
IUUC-Ssc-116103	Sus scrofa	82.06	0.00e+00	1773.00
IUUC-Tgu-117275	Taeniopygia guttata	84.39	0.00e+00	1811.00
IUUC-Tru-118681	Takifugu rubripes	90.65	0.00e+00	1993.00
IUUC-Tsy-118985	Tarsius syrichta	71.82	0.00e+00	827.00
IUUC-Tni-120850	Tetraodon nigroviridis	97.49	0.00e+00	815.00
IUUC-Tca-121770	Theobroma cacao	39.89	1.00e-113	405.00
IUUC-Tae-125466	Triticum aestivum	38.01	3.00e-110	393.00
IUUC-Tur-126086	Triticum urartu	40.14	1.00e-108	388.00
IUUC-Tbe-127461	Tupaia belangeri	76.45	0.00e+00	1608.00
IUUC-Ttr-129269	Tursiops truncatus	81.40	0.00e+00	1751.00
IUUC-Vpa-130523	Vicugna pacos	73.18	1.00e-112	401.00
IUUC-Vvi-131524	Vitis vinifera	39.86	6.00e-112	399.00
IUUC-Xtr-132146	Xenopus tropicalis	82.84	0.00e+00	1820.00
IUUC-Xma-133526	Xiphophorus maculatus	91.39	0.00e+00	1973.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence