iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019650.3	ENSMMUT00000027602.3	ENSMMUP00000025816.3
ENSMMUG00000019650.3	ENSMMUT00000027600.3	ENSMMUP00000025814.3
ENSMMUG00000019650.3	ENSMMUT00000071482.1	ENSMMUP00000042735.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-113	380.7	703	1068

Active Site

Position(s)	Description	Evidence
1036	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka++
   Q: 703  QHAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVY 787
           7899********************************************99987665.59*******76.****************** PP
   S: 84   dgrlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           +g ++d+p++++f+++llg+       s+++l+++d+e+yk+l++ik++ + di +lgl+l++  +e+++g+  ++eL+pgG++ipV
   Q: 788  EGIVVDVPFASFFLSQLLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDIADLGLTLSY--DEDVMGQLVCHELIPGGKTIPV 871
           ********************777777999********************.6788887777766..6999****************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwe 251
           tneNk +Y++l++++r++++ik+q++a+ +Gf+++i++e++++F++ el+ li+G+ +eid+edlkk+t y gg++ ++++i+w+w+
   Q: 872  TNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSAPELQRLISGDnAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD 958
           ********************************************************9****************************** PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++f+ +er++fL+FvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Y
   Q: 959  ILaSDFTPDERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
           **99*************************************************************8888****************** PP
   S: 314  sskeilkekLlyAieetkgFels 336
           s+k++l+ekL+yAi++++gFels
   Q: 1046 SKKSVLREKLRYAISMNTGFELS 1068
           ********************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MFTLSQTSRA WFIDRARQAR EERLVQKERE RAAVVIQAHV RSFLCRSRLQ RDIRREIDDF 60
FKADDPGSTK RSALCVFKIA RKLLFVFRIK EDNERFEKLC RSILSSMDAE NEPKVWYVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAATAAC AAGCTTTTCT GAAGTGAGAA GCTGTTCTCA GCCACGAGTC CCGTGCAAGA 60
TCACTAATGA TTACCTGACA TTTCTGCGAC ACAGGCAGGT CCTCAGGTGA GATCTCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mcc:707324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	36.38	6.00e-107	382.00
IUUC-Aml-002107	Ailuropoda melanoleuca	96.63	0.00e+00	2095.00
IUUC-Atr-003017	Amborella trichopoda	38.65	2.00e-110	394.00
IUUC-Apl-003328	Anas platyrhynchos	89.99	0.00e+00	1860.00
IUUC-Aly-005794	Arabidopsis lyrata	39.11	7.00e-110	392.00
IUUC-Ath-007269	Arabidopsis thaliana	39.46	3.00e-112	400.00
IUUC-Bta-013547	Bos taurus	95.69	0.00e+00	2100.00
IUUC-Bdi-014502	Brachypodium distachyon	39.32	2.00e-110	394.00
IUUC-Bol-015093	Brassica oleracea	39.82	1.00e-112	401.00
IUUC-Bra-016722	Brassica rapa	40.18	2.00e-114	407.00
IUUC-Cel-018447	Caenorhabditis elegans	38.04	0.00e+00	686.00
IUUC-Cja-019855	Callithrix jacchus	98.60	0.00e+00	2137.00
IUUC-Cfa-020066	Canis familiaris	96.40	0.00e+00	2072.00
IUUC-Cpo-021504	Cavia porcellus	95.32	0.00e+00	2083.00
IUUC-Csa-023579	Chlorocebus sabaeus	99.91	0.00e+00	2161.00
IUUC-Cho-024430	Choloepus hoffmanni	85.68	0.00e+00	1548.00
IUUC-Cin-025750	Ciona intestinalis	47.44	0.00e+00	978.00
IUUC-Csv-026016	Ciona savignyi	48.23	0.00e+00	1027.00
IUUC-Dre-028271	Danio rerio	81.40	0.00e+00	1763.00
IUUC-Dno-029054	Dasypus novemcinctus	96.07	0.00e+00	2085.00
IUUC-Dor-030938	Dipodomys ordii	87.83	0.00e+00	1865.00
IUUC-Dme-031602	Drosophila melanogaster	47.92	0.00e+00	966.00
IUUC-Ete-033041	Echinops telfairi	76.82	0.00e+00	1377.00
IUUC-Eca-034411	Equus caballus	96.72	0.00e+00	2074.00
IUUC-Eeu-035201	Erinaceus europaeus	85.13	0.00e+00	808.00
IUUC-Fca-036594	Felis catus	95.41	0.00e+00	2048.00
IUUC-Fal-037317	Ficedula albicollis	85.11	0.00e+00	1871.00
IUUC-Gmo-039412	Gadus morhua	77.65	0.00e+00	1726.00
IUUC-Gga-040149	Gallus gallus	88.60	0.00e+00	1890.00
IUUC-Gac-042088	Gasterosteus aculeatus	80.21	0.00e+00	1812.00
IUUC-Gma-042728	Glycine max	40.85	5.00e-112	399.00
IUUC-Ggo-045279	Gorilla gorilla	98.88	0.00e+00	2144.00
IUUC-Hsa-045660	Homo sapiens	98.60	0.00e+00	2137.00
IUUC-Hvu-047102	Hordeum vulgare	36.38	3.00e-107	383.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	94.31	0.00e+00	1058.00
IUUC-Lch-050664	Latimeria chalumnae	82.45	0.00e+00	1823.00
IUUC-Lpe-050755	Leersia perrieri	37.21	8.00e-99	355.00
IUUC-Loc-052791	Lepisosteus oculatus	82.77	0.00e+00	1785.00
IUUC-Laf-053902	Loxodonta africana	96.25	0.00e+00	2092.00
IUUC-Meu-056527	Macropus eugenii	79.94	0.00e+00	1677.00
IUUC-Mtr-057671	Medicago truncatula	39.61	3.00e-112	400.00
IUUC-Mga-059260	Meleagris gallopavo	88.34	0.00e+00	1892.00
IUUC-Mmr-060804	Microcebus murinus	94.67	0.00e+00	2011.00
IUUC-Mdo-062575	Monodelphis domestica	83.94	0.00e+00	1790.00
IUUC-Mmu-063636	Mus musculus	91.87	0.00e+00	1952.00
IUUC-Mac-064989	Musa acuminata	39.54	9.00e-108	385.00
IUUC-Mpu-066677	Mustela putorius furo	96.42	0.00e+00	1961.00
IUUC-Mlu-067952	Myotis lucifugus	95.32	0.00e+00	1993.00
IUUC-Nle-069153	Nomascus leucogenys	98.69	0.00e+00	2139.00
IUUC-Opr-070554	Ochotona princeps	94.79	0.00e+00	1879.00
IUUC-Ont-071372	Oreochromis niloticus	81.20	0.00e+00	1794.00
IUUC-Oan-073327	Ornithorhynchus anatinus	71.21	0.00e+00	734.00
IUUC-Ocu-074183	Oryctolagus cuniculus	95.33	0.00e+00	2049.00
IUUC-Oba-075213	Oryza barthii	38.82	5.00e-107	382.00
IUUC-Obr-076320	Oryza brachyantha	35.52	3.00e-110	393.00
IUUC-Ogl-077093	Oryza glaberrima	39.27	1.00e-109	391.00
IUUC-Ogu-078947	Oryza glumaepatula	36.81	6.00e-110	392.00
IUUC-Oin-080058	Oryza indica	39.27	2.00e-109	390.00
IUUC-Olo-080742	Oryza longistaminata	35.32	7.00e-109	389.00
IUUC-Ome-081741	Oryza meridionalis	34.86	1.00e-102	368.00
IUUC-Oni-082385	Oryza nivara	36.81	5.00e-110	392.00
IUUC-Opu-083529	Oryza punctata	35.36	1.00e-109	391.00
IUUC-Oru-085128	Oryza rufipogon	36.87	5.00e-96	346.00
IUUC-Osa-085557	Oryza sativa	39.54	4.00e-109	389.00
IUUC-Ola-087337	Oryzias latipes	80.54	0.00e+00	1732.00
IUUC-Oga-088342	Otolemur garnettii	95.70	0.00e+00	1993.00
IUUC-Oar-090234	Ovis aries	95.55	0.00e+00	2073.00
IUUC-Ptr-091661	Pan troglodytes	98.97	0.00e+00	2145.00
IUUC-Pan-092728	Papio anubis	99.63	0.00e+00	2155.00
IUUC-Psi-093251	Pelodiscus sinensis	87.88	0.00e+00	1756.00
IUUC-Pma-094195	Petromyzon marinus	69.74	0.00e+00	1444.00
IUUC-Ppa-095544	Physcomitrella patens	38.03	1.00e-110	394.00
IUUC-Pfo-097472	Poecilia formosa	80.82	0.00e+00	1796.00
IUUC-Pab-098570	Pongo abelii	98.60	0.00e+00	2136.00
IUUC-Pca-100110	Procavia capensis	83.61	0.00e+00	1745.00
IUUC-Ppe-101281	Prunus persica	39.18	8.00e-108	385.00
IUUC-Pva-102887	Pteropus vampyrus	91.39	0.00e+00	1947.00
IUUC-Rno-106028	Rattus norvegicus	89.08	0.00e+00	1852.00
IUUC-Sha-107331	Sarcophilus harrisii	85.26	0.00e+00	1815.00
IUUC-Smo-109488	Selaginella moellendorffii	37.14	4.00e-106	379.00
IUUC-Sit-109811	Setaria italica	35.90	7.00e-112	398.00
IUUC-Sly-111362	Solanum lycopersicum	35.35	2.00e-101	363.00
IUUC-Sar-113287	Sorex araneus	85.95	0.00e+00	738.00
IUUC-Sbi-114433	Sorghum bicolor	35.81	2.00e-112	400.00
IUUC-Ssc-116103	Sus scrofa	96.63	0.00e+00	2063.00
IUUC-Tgu-117275	Taeniopygia guttata	88.22	0.00e+00	1879.00
IUUC-Tru-118681	Takifugu rubripes	79.70	0.00e+00	1801.00
IUUC-Tsy-118985	Tarsius syrichta	92.59	0.00e+00	1050.00
IUUC-Tni-120850	Tetraodon nigroviridis	91.23	0.00e+00	775.00
IUUC-Tca-121770	Theobroma cacao	39.36	5.00e-112	399.00
IUUC-Tae-125466	Triticum aestivum	36.66	2.00e-108	387.00
IUUC-Tur-126086	Triticum urartu	36.38	3.00e-106	380.00
IUUC-Tbe-127461	Tupaia belangeri	91.67	0.00e+00	1905.00
IUUC-Ttr-129269	Tursiops truncatus	95.88	0.00e+00	2045.00
IUUC-Vpa-130523	Vicugna pacos	76.68	6.00e-128	452.00
IUUC-Vvi-131524	Vitis vinifera	39.22	1.00e-109	391.00
IUUC-Xtr-132146	Xenopus tropicalis	83.77	0.00e+00	1841.00
IUUC-Xma-133526	Xiphophorus maculatus	80.54	0.00e+00	1789.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence