iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026171.12	ENSMUST00000135140.7	ENSMUSP00000138040.1
ENSMUSG00000026171.12	ENSMUST00000027357.11	ENSMUSP00000027357.5
ENSMUSG00000026171.12	ENSMUST00000113721.7	ENSMUSP00000109350.1
ENSMUSG00000026171.12	ENSMUST00000136078.1	ENSMUSP00000117692.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.90e-06	28.4	134	199

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkw...........pglknssskefr.................CPlCr 46
           C iCl+ f  k+    +pC H fh +Cl ++                      +                 CP+Cr
   Q: 134  CVICLYGFqeKEAFTKTPCYHYFHCHCLARYiqhmeqelttqE----------QeqerqhvvtkqkavgvqCPVCR 199
           ********65333556************999755554444330..........244555666666667777****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity).

Protein Sequence
(Fasta)

MAASASTAAG EEDWVLPSEV EVLESIYLDE LQVMKGNGRS PWEIFITLHP ATAEVQDSQF 60
VCFTLVLRIP VQYPHEVPQI SIRNPRGLSD EQIHKISQAL GHVAKEGLGT AMLYELIEKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCCGGTT CCGGCCAAGA GCCGGAGAAG ACATGGCGGC GTCTGCGTCG ACAGCTGCTG 60
GGGAAGAGGA CTGGTAACTT TGGGTCATAG GTTTTGGCTG GCTGCCTGGA TCTGGTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50908--RWD
PS50089--ZF_RING_2

Pfam

PF05773--RWD

SMART

SM00184--RING
SM00591--RWD

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0051059--F:NF-kappaB binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0016567--P:protein ubiquitination

KEGG

mmu:57751

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001954	Ailuropoda melanoleuca	80.17	0.00e+00	640.00
IUUC-Atr-002830	Amborella trichopoda	24.02	6.00e-15	75.10
IUUC-Apl-003293	Anas platyrhynchos	68.77	6.00e-94	337.00
IUUC-Aca-005092	Anolis carolinensis	48.43	1.00e-110	393.00
IUUC-Aly-005434	Arabidopsis lyrata	28.05	5.00e-19	88.20
IUUC-Ath-006770	Arabidopsis thaliana	28.40	2.00e-17	83.20
IUUC-Ame-011754	Astyanax mexicanus	49.62	1.00e-57	217.00
IUUC-Bta-012592	Bos taurus	77.07	0.00e+00	641.00
IUUC-Bdi-015061	Brachypodium distachyon	25.00	1.00e-15	77.40
IUUC-Bol-015743	Brassica oleracea	29.91	2.00e-17	83.20
IUUC-Bra-018072	Brassica rapa	28.51	1.00e-14	74.30
IUUC-Cel-018515	Caenorhabditis elegans	25.76	2.00e-06	46.20
IUUC-Cja-018930	Callithrix jacchus	83.15	0.00e+00	702.00
IUUC-Cfa-020156	Canis familiaris	80.39	0.00e+00	675.00
IUUC-Cpo-021290	Cavia porcellus	77.16	0.00e+00	671.00
IUUC-Csa-023214	Chlorocebus sabaeus	82.57	0.00e+00	694.00
IUUC-Cin-025416	Ciona intestinalis	34.24	1.00e-41	164.00
IUUC-Csv-026360	Ciona savignyi	34.08	1.00e-43	171.00
IUUC-Dre-028670	Danio rerio	49.25	2.00e-55	209.00
IUUC-Dno-029970	Dasypus novemcinctus	78.65	0.00e+00	681.00
IUUC-Dor-030152	Dipodomys ordii	79.69	0.00e+00	649.00
IUUC-Dme-031914	Drosophila melanogaster	34.57	3.00e-37	149.00
IUUC-Ete-033105	Echinops telfairi	69.72	4.00e-142	498.00
IUUC-Eca-033800	Equus caballus	79.74	0.00e+00	634.00
IUUC-Eeu-034525	Erinaceus europaeus	60.04	2.00e-111	395.00
IUUC-Fca-035644	Felis catus	81.84	0.00e+00	715.00
IUUC-Fal-037121	Ficedula albicollis	50.80	7.00e-110	390.00
IUUC-Gmo-039444	Gadus morhua	50.40	2.00e-57	216.00
IUUC-Gga-041221	Gallus gallus	44.25	2.00e-75	276.00
IUUC-Gac-042354	Gasterosteus aculeatus	47.83	8.00e-68	251.00
IUUC-Gma-043721	Glycine max	28.25	1.00e-14	74.30
IUUC-Ggo-044879	Gorilla gorilla	82.57	0.00e+00	702.00
IUUC-Hsa-045739	Homo sapiens	82.35	0.00e+00	701.00
IUUC-Itr-047915	Ictidomys tridecemlineatus	84.53	0.00e+00	677.00
IUUC-Lch-050277	Latimeria chalumnae	58.90	2.00e-66	246.00
IUUC-Lpe-051139	Leersia perrieri	28.57	5.00e-18	85.10
IUUC-Loc-052367	Lepisosteus oculatus	56.96	2.00e-19	86.30
IUUC-Laf-053559	Loxodonta africana	75.27	0.00e+00	682.00
IUUC-Mcc-055367	Macaca mulatta	74.73	0.00e+00	639.00
IUUC-Meu-056730	Macropus eugenii	66.14	7.00e-134	470.00
IUUC-Mtr-058418	Medicago truncatula	26.18	5.00e-15	75.50
IUUC-Mga-060090	Meleagris gallopavo	68.75	2.00e-63	236.00
IUUC-Mmr-060618	Microcebus murinus	83.44	0.00e+00	713.00
IUUC-Mdo-063084	Monodelphis domestica	67.18	8.00e-145	506.00
IUUC-Mac-064922	Musa acuminata	27.82	2.00e-17	82.80
IUUC-Mpu-066419	Mustela putorius furo	79.30	0.00e+00	650.00
IUUC-Mlu-067289	Myotis lucifugus	76.96	0.00e+00	648.00
IUUC-Nle-069090	Nomascus leucogenys	83.01	0.00e+00	726.00
IUUC-Opr-070601	Ochotona princeps	77.46	2.00e-180	625.00
IUUC-Ont-072434	Oreochromis niloticus	51.36	1.00e-66	246.00
IUUC-Ocu-074855	Oryctolagus cuniculus	79.65	0.00e+00	667.00
IUUC-Oba-075792	Oryza barthii	27.02	2.00e-17	83.20
IUUC-Obr-076917	Oryza brachyantha	26.01	2.00e-17	83.20
IUUC-Ogl-077872	Oryza glaberrima	25.26	4.00e-15	75.90
IUUC-Ogu-078151	Oryza glumaepatula	25.42	2.00e-16	80.10
IUUC-Oin-079465	Oryza indica	25.78	8.00e-17	81.30
IUUC-Olo-080907	Oryza longistaminata	26.32	5.00e-13	69.70
IUUC-Ome-081752	Oryza meridionalis	25.26	5.00e-16	79.00
IUUC-Oni-082420	Oryza nivara	26.46	2.00e-16	80.50
IUUC-Opu-083810	Oryza punctata	27.68	1.00e-17	84.30
IUUC-Oru-085177	Oryza rufipogon	26.33	2.00e-17	83.20
IUUC-Ola-087231	Oryzias latipes	50.72	2.00e-49	188.00
IUUC-Oga-088963	Otolemur garnettii	83.44	0.00e+00	722.00
IUUC-Oar-089292	Ovis aries	77.17	0.00e+00	691.00
IUUC-Ptr-091214	Pan troglodytes	83.01	0.00e+00	707.00
IUUC-Pan-092823	Papio anubis	82.79	0.00e+00	749.00
IUUC-Psi-094084	Pelodiscus sinensis	39.02	1.00e-43	170.00
IUUC-Pfo-096406	Poecilia formosa	48.25	9.00e-61	227.00
IUUC-Pab-098212	Pongo abelii	83.44	0.00e+00	712.00
IUUC-Pop-099369	Populus trichocarpa	25.51	2.00e-15	76.60
IUUC-Pca-100897	Procavia capensis	70.81	4.00e-168	584.00
IUUC-Ppe-101702	Prunus persica	24.51	3.00e-14	72.80
IUUC-Pva-102899	Pteropus vampyrus	78.43	0.00e+00	654.00
IUUC-Rno-105369	Rattus norvegicus	94.96	0.00e+00	842.00
IUUC-Sha-107344	Sarcophilus harrisii	66.14	7.00e-136	477.00
IUUC-Smo-109636	Selaginella moellendorffii	25.33	2.00e-09	55.10
IUUC-Sit-109795	Setaria italica	26.38	6.00e-19	88.20
IUUC-Sly-111014	Solanum lycopersicum	25.16	6.00e-17	83.20
IUUC-Stu-112139	Solanum tuberosum	25.93	7.00e-19	87.80
IUUC-Sar-113487	Sorex araneus	85.71	1.00e-49	191.00
IUUC-Sbi-114714	Sorghum bicolor	26.80	1.00e-17	83.60
IUUC-Ssc-115465	Sus scrofa	75.82	0.00e+00	676.00
IUUC-Tgu-117113	Taeniopygia guttata	72.17	2.00e-95	342.00
IUUC-Tsy-119186	Tarsius syrichta	70.83	1.00e-52	200.00
IUUC-Tni-120219	Tetraodon nigroviridis	51.70	1.00e-35	141.00
IUUC-Tca-121748	Theobroma cacao	27.38	6.00e-14	71.60
IUUC-Tae-123014	Triticum aestivum	27.76	7.00e-15	74.70
IUUC-Tbe-127584	Tupaia belangeri	70.50	3.00e-113	401.00
IUUC-Ttr-128244	Tursiops truncatus	78.65	0.00e+00	643.00
IUUC-Vpa-130354	Vicugna pacos	79.33	0.00e+00	671.00
IUUC-Xtr-132402	Xenopus tropicalis	52.16	2.00e-70	259.00
IUUC-Xma-133442	Xiphophorus maculatus	46.43	3.00e-61	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence