iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.30e-16	61.3	230	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR++Ir++lg+qrl++i  LPLP+sLk+YL+y+
   Q: 230  LDPEPLPLMDLCRRSIRSALGRQRLRDIGSLPLPQSLKNYLQYQ 273
           5679**************************************97 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQKLSGSLK SVEVREPALR PAKRELRGLE PGRPARLDQL LDMPAAGLAV QLRHAWNPED 60
RSLNVFVKDD DRLTFHRHPV AQSTDGIRGK VGHARGLHAW QIHWPARQRG THAVVGVATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGATCGGC TTTCAGCTGC AGCCTCCGGG CCGGCCGGGA AGGCGGGGAG CGAGCGGCCG 60
TGGAGGAGGA GGGGGAGGCG GCGGCTGCAG CATCCAGAGC TGGCCCTGGC GGTCGGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

mmu:211949

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001823	Ailuropoda melanoleuca	96.34	1.00e-153	535.00
IUUC-Aca-004723	Anolis carolinensis	82.05	1.00e-134	472.00
IUUC-Ame-010730	Astyanax mexicanus	77.98	3.00e-118	417.00
IUUC-Bta-012654	Bos taurus	97.07	5.00e-155	540.00
IUUC-Cel-018566	Caenorhabditis elegans	54.65	8.00e-79	287.00
IUUC-Cja-019343	Callithrix jacchus	97.07	5.00e-155	540.00
IUUC-Cfa-020061	Canis familiaris	96.34	4.00e-154	536.00
IUUC-Cpo-021975	Cavia porcellus	96.34	8.00e-153	532.00
IUUC-Csa-023630	Chlorocebus sabaeus	98.24	5.00e-131	459.00
IUUC-Cho-024458	Choloepus hoffmanni	92.41	9.00e-76	276.00
IUUC-Dre-028237	Danio rerio	78.70	6.00e-120	423.00
IUUC-Ete-033077	Echinops telfairi	94.87	3.00e-151	527.00
IUUC-Eca-033453	Equus caballus	94.53	5.00e-149	520.00
IUUC-Fal-036622	Ficedula albicollis	82.05	2.00e-134	471.00
IUUC-Gmo-038808	Gadus morhua	76.26	7.00e-120	423.00
IUUC-Gga-040436	Gallus gallus	81.68	1.00e-134	472.00
IUUC-Ggo-045156	Gorilla gorilla	97.80	3.00e-156	543.00
IUUC-Hsa-046998	Homo sapiens	97.80	3.00e-156	543.00
IUUC-Itr-048821	Ictidomys tridecemlineatus	98.27	3.00e-132	463.00
IUUC-Lch-050022	Latimeria chalumnae	81.06	4.00e-123	433.00
IUUC-Loc-051943	Lepisosteus oculatus	82.05	2.00e-135	474.00
IUUC-Laf-053747	Loxodonta africana	93.04	3.00e-147	514.00
IUUC-Meu-056163	Macropus eugenii	85.35	4.00e-137	480.00
IUUC-Mmr-061796	Microcebus murinus	97.80	5.00e-156	543.00
IUUC-Mdo-062070	Monodelphis domestica	84.98	1.00e-136	478.00
IUUC-Mpu-066192	Mustela putorius furo	97.07	8.00e-155	539.00
IUUC-Mlu-067789	Myotis lucifugus	94.12	1.00e-130	458.00
IUUC-Nle-069241	Nomascus leucogenys	97.07	4.00e-155	540.00
IUUC-Ont-071823	Oreochromis niloticus	78.06	4.00e-121	427.00
IUUC-Oan-072734	Ornithorhynchus anatinus	82.05	4.00e-135	473.00
IUUC-Ola-087207	Oryzias latipes	76.26	2.00e-117	415.00
IUUC-Oga-089170	Otolemur garnettii	86.72	2.00e-136	477.00
IUUC-Ptr-090656	Pan troglodytes	97.80	3.00e-156	543.00
IUUC-Pan-092077	Papio anubis	98.17	8.00e-157	545.00
IUUC-Psi-093552	Pelodiscus sinensis	83.52	2.00e-136	478.00
IUUC-Pma-094441	Petromyzon marinus	53.11	3.00e-80	291.00
IUUC-Pfo-096646	Poecilia formosa	78.78	1.00e-121	429.00
IUUC-Pab-098256	Pongo abelii	97.07	1.00e-155	541.00
IUUC-Pca-100533	Procavia capensis	97.27	8.00e-104	369.00
IUUC-Pva-102621	Pteropus vampyrus	96.70	3.00e-154	536.00
IUUC-Rno-105152	Rattus norvegicus	100.00	4.00e-159	553.00
IUUC-Sha-107522	Sarcophilus harrisii	84.98	2.00e-136	478.00
IUUC-Sar-113664	Sorex araneus	95.60	6.00e-153	532.00
IUUC-Ssc-115430	Sus scrofa	97.80	1.00e-156	545.00
IUUC-Tgu-116552	Taeniopygia guttata	81.68	6.00e-134	469.00
IUUC-Tru-118631	Takifugu rubripes	74.48	2.00e-113	401.00
IUUC-Tsy-119192	Tarsius syrichta	98.27	1.00e-131	461.00
IUUC-Tni-120160	Tetraodon nigroviridis	77.74	3.00e-112	397.00
IUUC-Tae-124746	Triticum aestivum	45.45	4.10e-01	30.00
IUUC-Ttr-128238	Tursiops truncatus	97.44	3.00e-154	537.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence