iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091514

Ensembl Protein ID

ENSPTRP00000025728.4

UniProt Accession

H2QMK4; H2QMK4_PANTR

Genbank Protein ID

JAA07148.1; JAA15167.1; JAA31320.1; JAA33830.1

Protein Name

Ariadne homolog 2

Genbank Nucleotide ID

AACZ03025966; GABF01006978; GABD01001780; GABE01010909

Gene Name

ARIH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014902.5	ENSPTRT00000027893.4	ENSPTRP00000025728.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.10e-55	189.2	139	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC+ ++  +e++ +l+C+h+fC++C++q++++ +k+g  + +sc+a++cp +++e+ +  ll++eel ++y+++l++++ve++++l++
   Q: 139  CAVCM-QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQL 227
           9***9.77777888899************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp +dC +v+++++  ++ +v+c++c+++fC++C++++H++++C +++++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 228  CPGADCPMVIRVQEP-RARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCA---DDSETANYISAHTKDCPKCNICIEKNGGCNHM 313
           **************7.99*************************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C+kCk++fCw+C
   Q: 314  QCSKCKHDFCWMC 326
           ************* PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSVDMNSQGS DSNEEDYDPN CEEEEEEEDE DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ 60
FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGGACGA CTCTTCTGGA GGAAGCAGCG CGGGCTTGAC CGGCGTCGGC CCGCCGCCTC 60
CGCTGCCGCT TCGCCCCAAT CCGGTCCCTC TGACCCGGCC TGACCCGGTC TGGCTTGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0048588--P:developmental cell growth
GO:0071425--P:hematopoietic stem cell proliferation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001557	Ailuropoda melanoleuca	98.38	0.00e+00	937.00
IUUC-Apl-003878	Anas platyrhynchos	93.31	0.00e+00	876.00
IUUC-Aca-004865	Anolis carolinensis	92.49	0.00e+00	880.00
IUUC-Bta-012901	Bos taurus	98.17	0.00e+00	932.00
IUUC-Bra-017081	Brassica rapa	28.97	8.00e-58	218.00
IUUC-Cel-018334	Caenorhabditis elegans	48.64	5.00e-127	447.00
IUUC-Cja-019728	Callithrix jacchus	99.39	0.00e+00	941.00
IUUC-Cfa-020953	Canis familiaris	98.58	0.00e+00	937.00
IUUC-Cpo-021445	Cavia porcellus	98.78	0.00e+00	937.00
IUUC-Csa-023769	Chlorocebus sabaeus	99.59	0.00e+00	945.00
IUUC-Cho-024650	Choloepus hoffmanni	87.83	0.00e+00	793.00
IUUC-Cin-025577	Ciona intestinalis	54.55	1.00e-143	503.00
IUUC-Csv-025849	Ciona savignyi	55.84	2.00e-120	425.00
IUUC-Dre-028490	Danio rerio	79.64	0.00e+00	777.00
IUUC-Dno-029942	Dasypus novemcinctus	98.38	0.00e+00	934.00
IUUC-Dor-030134	Dipodomys ordii	84.98	5.00e-151	527.00
IUUC-Dme-031853	Drosophila melanogaster	55.06	2.00e-149	522.00
IUUC-Ete-032355	Echinops telfairi	89.27	0.00e+00	837.00
IUUC-Eca-033440	Equus caballus	98.58	0.00e+00	938.00
IUUC-Eeu-035230	Erinaceus europaeus	89.36	2.00e-115	408.00
IUUC-Fca-036308	Felis catus	92.31	0.00e+00	867.00
IUUC-Fal-036974	Ficedula albicollis	93.31	0.00e+00	876.00
IUUC-Gmo-038642	Gadus morhua	81.31	0.00e+00	779.00
IUUC-Gga-041019	Gallus gallus	93.31	0.00e+00	876.00
IUUC-Gac-042014	Gasterosteus aculeatus	80.28	0.00e+00	801.00
IUUC-Ggo-045329	Gorilla gorilla	100.00	0.00e+00	946.00
IUUC-Hsa-046712	Homo sapiens	99.59	0.00e+00	946.00
IUUC-Itr-048370	Ictidomys tridecemlineatus	99.04	0.00e+00	844.00
IUUC-Lch-049584	Latimeria chalumnae	85.83	0.00e+00	817.00
IUUC-Loc-051826	Lepisosteus oculatus	79.89	1.00e-164	572.00
IUUC-Laf-054567	Loxodonta africana	96.96	0.00e+00	917.00
IUUC-Mcc-054919	Macaca mulatta	99.59	0.00e+00	945.00
IUUC-Meu-056332	Macropus eugenii	91.28	0.00e+00	849.00
IUUC-Mga-060132	Meleagris gallopavo	93.33	0.00e+00	881.00
IUUC-Mmr-061599	Microcebus murinus	95.14	0.00e+00	887.00
IUUC-Mdo-062186	Monodelphis domestica	94.93	0.00e+00	801.00
IUUC-Mmu-064271	Mus musculus	97.77	0.00e+00	932.00
IUUC-Mpu-066827	Mustela putorius furo	96.67	0.00e+00	828.00
IUUC-Mlu-067528	Myotis lucifugus	97.36	0.00e+00	892.00
IUUC-Nle-068995	Nomascus leucogenys	100.00	0.00e+00	946.00
IUUC-Opr-070518	Ochotona princeps	98.58	0.00e+00	901.00
IUUC-Ont-071650	Oreochromis niloticus	83.27	0.00e+00	821.00
IUUC-Oan-073676	Ornithorhynchus anatinus	93.87	0.00e+00	753.00
IUUC-Ocu-073761	Oryctolagus cuniculus	99.59	0.00e+00	944.00
IUUC-Obr-076705	Oryza brachyantha	30.05	1.00e-58	221.00
IUUC-Ola-087204	Oryzias latipes	79.57	0.00e+00	793.00
IUUC-Oga-088098	Otolemur garnettii	98.78	0.00e+00	934.00
IUUC-Oar-089205	Ovis aries	98.17	0.00e+00	932.00
IUUC-Pan-092493	Papio anubis	94.83	0.00e+00	900.00
IUUC-Psi-093024	Pelodiscus sinensis	87.50	1.00e-117	415.00
IUUC-Pfo-097256	Poecilia formosa	82.04	0.00e+00	810.00
IUUC-Pab-098504	Pongo abelii	92.29	0.00e+00	846.00
IUUC-Pop-099547	Populus trichocarpa	30.85	2.00e-55	209.00
IUUC-Pca-100700	Procavia capensis	91.48	0.00e+00	837.00
IUUC-Pva-103105	Pteropus vampyrus	97.57	0.00e+00	923.00
IUUC-Rno-105289	Rattus norvegicus	97.97	0.00e+00	934.00
IUUC-Sha-107417	Sarcophilus harrisii	95.33	0.00e+00	872.00
IUUC-Sar-113042	Sorex araneus	95.98	0.00e+00	926.00
IUUC-Ssc-115362	Sus scrofa	98.78	0.00e+00	937.00
IUUC-Tgu-117469	Taeniopygia guttata	92.98	0.00e+00	828.00
IUUC-Tru-117976	Takifugu rubripes	80.39	0.00e+00	813.00
IUUC-Tsy-118876	Tarsius syrichta	86.36	2.00e-91	329.00
IUUC-Tni-119831	Tetraodon nigroviridis	80.20	0.00e+00	794.00
IUUC-Tca-121326	Theobroma cacao	28.91	3.00e-59	223.00
IUUC-Tbe-127386	Tupaia belangeri	92.50	4.00e-161	561.00
IUUC-Ttr-128315	Tursiops truncatus	98.38	0.00e+00	936.00
IUUC-Vpa-130383	Vicugna pacos	90.87	0.00e+00	837.00
IUUC-Xtr-132945	Xenopus tropicalis	90.67	0.00e+00	872.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence