iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048592

Ensembl Protein ID

ENSSTOP00000008987.2

UniProt Accession

I3MEN7; I3MEN7_ICTTR

Genbank Protein ID

ENSSTOP00000008987

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01049938

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000010016.2	ENSSTOT00000010018.2	ENSSTOP00000008987.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.60e-13	48.2	443	494

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy+++ +deL++   d+++ i  e+ degW++g    +g  GlfP+n+v+ l
   Q: 443  VALYDYQGEGSDELSFDPDDIITDI--EKVDEGWWRG--RCHGHFGLFPANYVKLL 494
           68***********************..9*********..8*************977 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRKE HINIHQLRSK 60
VSEEHDVLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGTGGAA GTCTGTAGTG GGTCATGATG TATCTGTTTC CGTGGAGACC CAGGGTGATG 60
ACTGGGACAC AGACCCTGAC TTTGTGGTGA GTTTGAAAGT CGTTTTTCTT GAACGATGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	67.75	9.00e-172	596.00
IUUC-Bta-012591	Bos taurus	74.08	8.00e-141	493.00
IUUC-Cja-019982	Callithrix jacchus	67.40	3.00e-161	560.00
IUUC-Cfa-020262	Canis familiaris	65.18	5.00e-157	547.00
IUUC-Cpo-021362	Cavia porcellus	66.24	4.00e-155	540.00
IUUC-Csa-023911	Chlorocebus sabaeus	74.63	3.00e-140	491.00
IUUC-Dor-030437	Dipodomys ordii	60.25	5.00e-139	487.00
IUUC-Ete-033160	Echinops telfairi	60.10	2.00e-81	295.00
IUUC-Eca-033269	Equus caballus	66.31	2.00e-164	571.00
IUUC-Eeu-035032	Erinaceus europaeus	61.11	4.00e-85	308.00
IUUC-Fca-035999	Felis catus	63.46	5.00e-159	553.00
IUUC-Fal-037107	Ficedula albicollis	60.86	3.00e-104	372.00
IUUC-Gga-040335	Gallus gallus	62.27	2.00e-104	372.00
IUUC-Ggo-044505	Gorilla gorilla	67.68	2.00e-165	575.00
IUUC-Hsa-046728	Homo sapiens	73.59	5.00e-138	484.00
IUUC-Laf-054202	Loxodonta africana	72.62	1.00e-134	473.00
IUUC-Mcc-055824	Macaca mulatta	74.38	3.00e-140	491.00
IUUC-Mmr-061281	Microcebus murinus	56.56	3.00e-95	341.00
IUUC-Mdo-062515	Monodelphis domestica	56.23	4.00e-126	444.00
IUUC-Mmu-064341	Mus musculus	73.96	4.00e-140	490.00
IUUC-Mpu-066565	Mustela putorius furo	72.75	1.00e-135	476.00
IUUC-Mlu-066942	Myotis lucifugus	62.89	8.00e-155	540.00
IUUC-Nle-069436	Nomascus leucogenys	74.57	1.00e-140	492.00
IUUC-Opr-070288	Ochotona princeps	62.84	1.00e-134	473.00
IUUC-Ocu-074686	Oryctolagus cuniculus	74.15	1.00e-126	446.00
IUUC-Ola-086894	Oryzias latipes	47.62	4.00e-83	301.00
IUUC-Oga-088585	Otolemur garnettii	60.75	5.00e-149	520.00
IUUC-Oar-089686	Ovis aries	67.62	8.00e-170	589.00
IUUC-Ptr-090461	Pan troglodytes	74.33	9.00e-140	489.00
IUUC-Pan-091887	Papio anubis	74.88	2.00e-141	495.00
IUUC-Pab-098222	Pongo abelii	73.84	1.00e-140	492.00
IUUC-Pca-100668	Procavia capensis	65.52	7.00e-159	553.00
IUUC-Pva-102767	Pteropus vampyrus	62.36	3.00e-95	341.00
IUUC-Rno-106001	Rattus norvegicus	64.97	8.00e-159	553.00
IUUC-Sar-113338	Sorex araneus	63.25	1.00e-102	366.00
IUUC-Ssc-116027	Sus scrofa	67.38	2.00e-167	582.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence