iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	97.57	3.00e-106	382.00	IUUC-Hsa-046401

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

Protein Sequence
(Fasta)

MASQPPEEPA EFQVSDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK IIDFGDSPQG 60
VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGSKGKKC LPENPTELLL TPKRLASLVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAATCGCCG GCGCCGCCGC CGGAGTGGCT CTCGGTCCTT CCATCGATCC TCCGGTCCGT 60
CCTCCCGCGG CCCCCGCCGC CGCTGGTCAG GTAAGGCGCG CGCCAGTACG CGCGACCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

rno:498726

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002157	Ailuropoda melanoleuca	95.90	1.00e-103	369.00
IUUC-Apl-003754	Anas platyrhynchos	92.62	1.00e-107	382.00
IUUC-Aca-005163	Anolis carolinensis	89.34	3.00e-102	363.00
IUUC-Ame-010899	Astyanax mexicanus	53.60	7.00e-52	197.00
IUUC-Bta-012609	Bos taurus	92.68	3.00e-94	337.00
IUUC-Cel-018112	Caenorhabditis elegans	42.86	3.00e-08	52.40
IUUC-Cja-019820	Callithrix jacchus	97.95	3.00e-107	380.00
IUUC-Cfa-020982	Canis familiaris	90.55	5.00e-56	209.00
IUUC-Cpo-021400	Cavia porcellus	96.76	2.00e-106	378.00
IUUC-Csa-023232	Chlorocebus sabaeus	97.17	8.00e-108	382.00
IUUC-Cho-024286	Choloepus hoffmanni	94.33	3.00e-103	367.00
IUUC-Dre-027461	Danio rerio	52.17	1.00e-39	156.00
IUUC-Dno-029613	Dasypus novemcinctus	92.17	3.00e-101	361.00
IUUC-Dor-030647	Dipodomys ordii	95.56	1.00e-104	372.00
IUUC-Eca-034110	Equus caballus	97.13	2.00e-105	375.00
IUUC-Eeu-034580	Erinaceus europaeus	97.13	7.00e-106	376.00
IUUC-Fca-036483	Felis catus	96.31	4.00e-105	373.00
IUUC-Fal-037213	Ficedula albicollis	90.98	1.00e-108	385.00
IUUC-Gmo-038766	Gadus morhua	49.44	5.00e-25	105.00
IUUC-Gga-041249	Gallus gallus	93.78	1.00e-99	355.00
IUUC-Gac-042045	Gasterosteus aculeatus	50.21	7.00e-54	203.00
IUUC-Ggo-045237	Gorilla gorilla	97.57	6.00e-108	383.00
IUUC-Hsa-046401	Homo sapiens	97.57	6.00e-108	383.00
IUUC-Itr-048794	Ictidomys tridecemlineatus	93.52	1.00e-103	368.00
IUUC-Lch-050274	Latimeria chalumnae	71.14	1.00e-83	302.00
IUUC-Loc-052382	Lepisosteus oculatus	58.54	7.00e-66	244.00
IUUC-Mcc-055173	Macaca mulatta	97.98	1.00e-108	385.00
IUUC-Meu-056310	Macropus eugenii	46.70	1.00e-47	182.00
IUUC-Mga-059578	Meleagris gallopavo	91.39	4.00e-105	374.00
IUUC-Mmr-060739	Microcebus murinus	97.17	3.00e-106	377.00
IUUC-Mdo-062765	Monodelphis domestica	93.12	1.00e-109	389.00
IUUC-Mmu-064145	Mus musculus	98.38	6.00e-109	386.00
IUUC-Mpu-066170	Mustela putorius furo	97.95	7.00e-107	379.00
IUUC-Mlu-067774	Myotis lucifugus	97.54	8.00e-118	416.00
IUUC-Nle-070141	Nomascus leucogenys	97.17	2.00e-107	381.00
IUUC-Opr-070247	Ochotona princeps	95.56	4.00e-108	383.00
IUUC-Ont-072312	Oreochromis niloticus	47.73	1.00e-58	219.00
IUUC-Oan-073640	Ornithorhynchus anatinus	85.37	2.00e-97	348.00
IUUC-Ocu-074191	Oryctolagus cuniculus	96.76	2.00e-106	378.00
IUUC-Ola-086432	Oryzias latipes	52.42	2.00e-56	211.00
IUUC-Oga-088498	Otolemur garnettii	98.36	9.00e-108	382.00
IUUC-Oar-089917	Ovis aries	94.31	1.00e-100	358.00
IUUC-Ptr-090460	Pan troglodytes	97.57	6.00e-108	383.00
IUUC-Pan-092766	Papio anubis	97.98	1.00e-108	385.00
IUUC-Psi-093943	Pelodiscus sinensis	91.39	3.00e-105	374.00
IUUC-Pfo-096878	Poecilia formosa	54.26	3.00e-60	224.00
IUUC-Pab-097922	Pongo abelii	97.17	9.00e-107	379.00
IUUC-Pca-100996	Procavia capensis	95.78	5.00e-58	216.00
IUUC-Pva-102313	Pteropus vampyrus	95.90	1.00e-115	408.00
IUUC-Sha-106544	Sarcophilus harrisii	93.93	2.00e-111	394.00
IUUC-Ssc-115614	Sus scrofa	95.49	2.00e-103	368.00
IUUC-Tgu-117096	Taeniopygia guttata	90.98	1.00e-108	385.00
IUUC-Tru-117656	Takifugu rubripes	48.88	1.00e-39	156.00
IUUC-Tsy-119244	Tarsius syrichta	96.76	9.00e-107	379.00
IUUC-Tni-120008	Tetraodon nigroviridis	42.06	6.00e-32	130.00
IUUC-Tbe-127391	Tupaia belangeri	98.36	6.00e-108	383.00
IUUC-Ttr-129115	Tursiops truncatus	93.85	5.00e-102	363.00
IUUC-Vpa-130722	Vicugna pacos	96.72	4.00e-105	374.00
IUUC-Xtr-131837	Xenopus tropicalis	83.84	3.00e-91	327.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence