iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097194

Ensembl Protein ID

ENSPFOP00000005486.1

UniProt Accession

A0A087XI83; A0A087XI83_POEFO

Genbank Protein ID

ENSPFOP00000005486

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AYCK01023398

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000005450.1	ENSPFOT00000005495.1	ENSPFOP00000005486.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	9.50e-10	38.8	3	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihlle 71
           v+v+   g    ++++ ++ VaeLKe + +++g+p++  r +++G++L+  ++L+ ++l+d st+h+++
   Q: 3    VFVRFNRGPGVAVELSAAAHVAELKEIVGRQQGVPAQALRVLFAGRELQSSDSLQGCDLPDQSTVHVVL 71
           7777888886688999999************************************************96 PP

Organism

Poecilia formosa

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

VAVFVRFNRG PGVAVELSAA AHVAELKEIV GRQQGVPAQA LRVLFAGREL QSSDSLQGCD 60
LPDQSTVHVV LPPPGSIHLL PLAARGTRLT RLDLSSSRLA VLEGGRGGGD EDQRTEQQAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGCAGTGT TTGTGCGGTT CAACCGCGGC CCCGGCGTTG CCGTGGAGCT CAGTGCGGCG 60
GCCCACGTGG CAGAGCTGAA GGAGATCGTG GGGAGGCAGC AGGGAGTTCC TGCCCAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0051865--P:protein autoubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	49.31	3.00e-71	261.00
IUUC-Apl-003304	Anas platyrhynchos	59.20	6.00e-117	413.00
IUUC-Aca-004908	Anolis carolinensis	50.47	5.00e-29	119.00
IUUC-Ame-011856	Astyanax mexicanus	61.09	1.00e-157	549.00
IUUC-Bta-013014	Bos taurus	52.94	9.00e-111	394.00
IUUC-Cel-018687	Caenorhabditis elegans	27.92	5.00e-44	171.00
IUUC-Cja-019274	Callithrix jacchus	47.75	1.00e-70	259.00
IUUC-Cfa-020461	Canis familiaris	48.96	1.00e-70	259.00
IUUC-Cpo-022251	Cavia porcellus	49.48	1.00e-72	266.00
IUUC-Csa-023112	Chlorocebus sabaeus	48.26	3.00e-67	248.00
IUUC-Cho-024504	Choloepus hoffmanni	37.09	1.00e-75	276.00
IUUC-Cne-027073	Cryptococcus neoformans	26.46	4.00e-11	62.00
IUUC-Dre-028202	Danio rerio	60.04	5.00e-145	507.00
IUUC-Dno-028946	Dasypus novemcinctus	56.00	2.00e-23	100.00
IUUC-Dor-030508	Dipodomys ordii	45.25	2.00e-75	276.00
IUUC-Dme-031980	Drosophila melanogaster	41.79	3.00e-103	369.00
IUUC-Ete-032281	Echinops telfairi	42.11	3.00e-48	186.00
IUUC-Eca-033228	Equus caballus	48.10	7.00e-71	260.00
IUUC-Fal-037507	Ficedula albicollis	54.45	2.00e-139	489.00
IUUC-Gmo-038744	Gadus morhua	60.78	7.00e-95	340.00
IUUC-Gga-040353	Gallus gallus	53.45	2.00e-136	479.00
IUUC-Gac-042519	Gasterosteus aculeatus	63.66	4.00e-169	587.00
IUUC-Hsa-046016	Homo sapiens	52.16	7.00e-131	460.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	53.23	3.00e-124	438.00
IUUC-Loc-052389	Lepisosteus oculatus	56.37	5.00e-142	497.00
IUUC-Mcc-054933	Macaca mulatta	51.94	3.00e-130	458.00
IUUC-Meu-055963	Macropus eugenii	42.26	1.00e-76	280.00
IUUC-Mga-059626	Meleagris gallopavo	58.67	6.00e-21	91.70
IUUC-Mmr-061566	Microcebus murinus	61.29	1.00e-62	232.00
IUUC-Mdo-061952	Monodelphis domestica	59.65	2.00e-18	83.60
IUUC-Mmu-063561	Mus musculus	53.13	7.00e-141	493.00
IUUC-Mpu-065799	Mustela putorius furo	49.00	2.00e-70	259.00
IUUC-Mlu-068134	Myotis lucifugus	51.12	1.00e-91	330.00
IUUC-Nle-070078	Nomascus leucogenys	48.00	3.00e-74	271.00
IUUC-Opr-070541	Ochotona princeps	52.36	3.00e-123	435.00
IUUC-Ont-071743	Oreochromis niloticus	70.18	8.00e-179	619.00
IUUC-Ola-086426	Oryzias latipes	71.35	1.00e-72	265.00
IUUC-Oga-088867	Otolemur garnettii	52.60	5.00e-132	464.00
IUUC-Oar-089365	Ovis aries	53.20	8.00e-101	360.00
IUUC-Ptr-091371	Pan troglodytes	51.94	1.00e-129	456.00
IUUC-Pan-092443	Papio anubis	47.92	5.00e-70	257.00
IUUC-Psi-093851	Pelodiscus sinensis	48.09	6.00e-58	217.00
IUUC-Pab-097999	Pongo abelii	44.15	3.00e-69	255.00
IUUC-Pca-100410	Procavia capensis	50.35	2.00e-107	382.00
IUUC-Pva-102300	Pteropus vampyrus	46.52	4.00e-107	382.00
IUUC-Rno-105556	Rattus norvegicus	49.83	3.00e-75	275.00
IUUC-Sar-113121	Sorex araneus	71.05	4.00e-43	168.00
IUUC-Ssc-116435	Sus scrofa	50.35	6.00e-72	264.00
IUUC-Tgu-117489	Taeniopygia guttata	53.46	5.00e-139	487.00
IUUC-Tru-117927	Takifugu rubripes	62.16	5.00e-171	593.00
IUUC-Tsy-119372	Tarsius syrichta	59.50	3.00e-110	392.00
IUUC-Tni-120043	Tetraodon nigroviridis	61.88	2.00e-161	562.00
IUUC-Tbe-127539	Tupaia belangeri	46.42	5.00e-107	381.00
IUUC-Ttr-129149	Tursiops truncatus	50.86	6.00e-133	467.00
IUUC-Vpa-130439	Vicugna pacos	40.69	4.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence