iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108223

Ensembl Protein ID

SPAC26A3.16.1:pep

UniProt Accession

Q10169; DSK2_SCHPO

Genbank Protein ID

CAA93239.1

Protein Name

Deubiquitination-protection protein dph1

Genbank Nucleotide ID

CU329670

Gene Name

dph1; SPAC26A3.16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC26A3.16	SPAC26A3.16.1	SPAC26A3.16.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	11584278; 12560082; 12672455
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10487753; 15209385

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	9.90e-11	39.6	315	352
ULD/UDP/UBQ/UBQ_PIM	2.90e-25	86.1	4	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGF.dreealqaLraannnleaAveyLld 40
            ++l ql eMGF d+e+++qaLr++++n++ A+e Ll+
   Q: 315  AEQLSQLNEMGFvDFERNVQALRRSGGNVQGAIESLLS 352
           589*********************************97 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           ++lt+k+ +++++ ++v+++++v +lKe+ia + ++++e+q+LIyaG++LkD+++L+ ++i+dg+ +hlv++ 
   Q: 4    ISLTIKAANDQKYAVTVDSESSVLALKEAIAPVADIEKERQRLIYAGRVLKDEESLKTYKIQDGHSIHLVKTL 76
           689*******************************************************************986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.

Protein Sequence
(Fasta)

MTNISLTIKA ANDQKYAVTV DSESSVLALK EAIAPVADIE KERQRLIYAG RVLKDEESLK 60
TYKIQDGHSI HLVKTLGQNP AAAATNVSDR TQQVPTNIQA GQGANNPLAN LTSARYAGFN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGAGTGGA AAATACCTAA CCAAACCCAA CAACATGACC AATATATCGT TGACTATTAA 60
GGCGGCAAAT GATCAAAAGT ACGCAGTTAC AGTTGATAGT GAATCTTCTG TACTTGCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0031593--F:polyubiquitin binding
GO:0042177--P:negative regulation of protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

spo:SPAC26A3.16

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000364	Aegilops tauschii	47.14	7.00e-14	71.20
IUUC-Aml-001461	Ailuropoda melanoleuca	52.38	3.00e-07	48.10
IUUC-Atr-002470	Amborella trichopoda	43.66	8.00e-16	76.60
IUUC-Apl-003681	Anas platyrhynchos	50.00	2.00e-08	52.00
IUUC-Aca-005226	Anolis carolinensis	43.06	2.00e-11	63.50
IUUC-Aly-005419	Arabidopsis lyrata	28.57	1.00e-16	79.30
IUUC-Ath-007350	Arabidopsis thaliana	28.57	3.00e-16	77.80
IUUC-Ago-007963	Ashbya gossypii	42.52	1.00e-42	164.00
IUUC-Acl-008361	Aspergillus clavatus	50.45	1.00e-46	178.00
IUUC-Afl-008403	Aspergillus flavus	49.33	1.00e-46	178.00
IUUC-Afu-009029	Aspergillus fumigatus	46.61	4.00e-42	163.00
IUUC-Ani-009418	Aspergillus nidulans	48.64	2.00e-40	157.00
IUUC-Ang-009826	Aspergillus niger	50.67	6.00e-49	186.00
IUUC-Aor-010091	Aspergillus oryzae	49.33	1.00e-46	178.00
IUUC-Ate-010419	Aspergillus terreus	47.77	9.00e-51	192.00
IUUC-Ame-011606	Astyanax mexicanus	44.44	6.00e-12	65.10
IUUC-Bgr-012188	Blumeria graminis	40.62	9.00e-43	165.00
IUUC-Bta-013571	Bos taurus	54.76	8.00e-08	50.10
IUUC-Bci-013628	Botrytis cinerea	42.51	6.00e-37	146.00
IUUC-Bdi-015055	Brachypodium distachyon	48.61	2.00e-14	72.40
IUUC-Bol-016303	Brassica oleracea	26.37	2.00e-14	72.00
IUUC-Bra-017101	Brassica rapa	27.32	3.00e-20	90.90
IUUC-Cel-018631	Caenorhabditis elegans	41.10	8.00e-11	59.70
IUUC-Cja-019976	Callithrix jacchus	52.38	3.00e-07	48.10
IUUC-Cfa-020092	Canis familiaris	52.38	3.00e-07	48.10
IUUC-Cpo-022093	Cavia porcellus	26.90	7.00e-09	53.90
IUUC-Csa-023627	Chlorocebus sabaeus	54.76	7.00e-08	50.40
IUUC-Cho-024834	Choloepus hoffmanni	36.67	2.00e-07	48.90
IUUC-Cin-025136	Ciona intestinalis	35.00	6.00e-08	50.40
IUUC-Csv-026009	Ciona savignyi	34.29	5.00e-09	54.30
IUUC-Cgl-026590	Colletotrichum gloeosporioides	33.33	1.00e-26	111.00
IUUC-Cne-026833	Cryptococcus neoformans	37.79	1.00e-35	142.00
IUUC-Cme-027155	Cyanidioschyzon merolae	36.84	8.00e-10	56.60
IUUC-Dre-028009	Danio rerio	24.69	6.00e-11	60.50
IUUC-Dno-029647	Dasypus novemcinctus	54.76	8.00e-08	50.10
IUUC-Dor-030519	Dipodomys ordii	39.29	2.00e-07	48.50
IUUC-Dse-031421	Dothistroma septosporum	41.63	9.00e-33	132.00
IUUC-Dme-032013	Drosophila melanogaster	53.06	3.00e-09	54.70
IUUC-Ete-032486	Echinops telfairi	34.29	8.00e-09	53.10
IUUC-Eca-033667	Equus caballus	34.29	4.00e-08	51.20
IUUC-Eeu-034865	Erinaceus europaeus	38.89	6.00e-07	47.40
IUUC-Fca-036179	Felis catus	37.50	6.00e-07	47.00
IUUC-Fal-037180	Ficedula albicollis	54.76	5.00e-08	50.80
IUUC-Fox-037726	Fusarium oxysporum	38.61	5.00e-35	140.00
IUUC-Fso-038204	Fusarium solani	37.62	2.00e-32	131.00
IUUC-Gmo-039317	Gadus morhua	36.11	2.00e-09	55.50
IUUC-Ggr-039961	Gaeumannomyces graminis	42.65	1.00e-39	154.00
IUUC-Gga-041050	Gallus gallus	35.71	9.00e-09	53.10
IUUC-Gac-042311	Gasterosteus aculeatus	26.76	3.00e-10	58.20
IUUC-Gma-043430	Glycine max	36.62	2.00e-15	75.10
IUUC-Ggo-044519	Gorilla gorilla	54.76	7.00e-08	50.40
IUUC-Hsa-046768	Homo sapiens	54.76	8.00e-08	50.10
IUUC-Hvu-047698	Hordeum vulgare	41.24	9.00e-15	73.20
IUUC-Itr-048007	Ictidomys tridecemlineatus	38.89	1.00e-09	57.00
IUUC-Kpa-049251	Komagataella pastoris	44.44	6.00e-48	182.00
IUUC-Lch-049762	Latimeria chalumnae	44.44	1.00e-11	63.20
IUUC-Lpe-050974	Leersia perrieri	44.29	8.00e-16	76.60
IUUC-Loc-051845	Lepisosteus oculatus	34.29	2.00e-08	52.40
IUUC-Lma-053152	Leptosphaeria maculans	43.89	4.00e-35	140.00
IUUC-Laf-053920	Loxodonta africana	54.76	7.00e-08	50.10
IUUC-Mcc-054658	Macaca mulatta	54.76	7.00e-08	50.10
IUUC-Meu-056280	Macropus eugenii	43.06	5.00e-11	61.60
IUUC-Mor-057194	Magnaporthe oryzae	43.06	8.00e-40	155.00
IUUC-Mpo-057467	Magnaporthe poae	82.98	5.00e-19	84.30
IUUC-Mtr-057772	Medicago truncatula	38.67	8.00e-16	76.60
IUUC-Mla-058987	Melampsora laricipopulina	43.69	5.00e-25	106.00
IUUC-Mga-059730	Meleagris gallopavo	36.17	1.00e-05	43.10
IUUC-Mvi-060466	Microbotryum violaceum	38.92	3.00e-24	103.00
IUUC-Mmr-061094	Microcebus murinus	52.38	3.00e-07	48.10
IUUC-Mdo-062059	Monodelphis domestica	41.67	2.00e-10	60.10
IUUC-Mmu-064088	Mus musculus	27.09	3.00e-09	54.70
IUUC-Mac-065526	Musa acuminata	29.86	1.00e-19	89.40
IUUC-Mpu-066282	Mustela putorius furo	52.38	3.00e-07	48.10
IUUC-Mlu-068158	Myotis lucifugus	52.38	3.00e-07	48.10
IUUC-Nfi-068487	Neosartorya fischeri	46.61	1.00e-42	165.00
IUUC-Ncr-068732	Neurospora crassa	38.73	4.00e-35	140.00
IUUC-Nle-069038	Nomascus leucogenys	54.76	7.00e-08	50.40
IUUC-Opr-070323	Ochotona princeps	35.71	8.00e-09	53.50
IUUC-Ont-071931	Oreochromis niloticus	43.06	3.00e-11	62.80
IUUC-Oan-072808	Ornithorhynchus anatinus	48.94	3.00e-07	48.10
IUUC-Ocu-074301	Oryctolagus cuniculus	28.17	6.00e-10	57.40
IUUC-Oba-075114	Oryza barthii	29.73	2.00e-16	79.00
IUUC-Obr-076574	Oryza brachyantha	41.05	2.00e-14	72.40
IUUC-Ogl-077147	Oryza glaberrima	29.73	2.00e-16	79.00
IUUC-Ogu-078322	Oryza glumaepatula	29.73	2.00e-16	79.00
IUUC-Oin-080117	Oryza indica	29.73	2.00e-16	79.00
IUUC-Olo-080565	Oryza longistaminata	43.10	1.00e-10	59.30
IUUC-Ome-081155	Oryza meridionalis	45.71	8.00e-17	79.70
IUUC-Oni-082060	Oryza nivara	29.73	2.00e-16	79.00
IUUC-Opu-083366	Oryza punctata	47.22	4.00e-14	71.20
IUUC-Oru-084808	Oryza rufipogon	29.73	2.00e-16	79.00
IUUC-Osa-085932	Oryza sativa	29.73	2.00e-16	79.00
IUUC-Ola-086802	Oryzias latipes	27.47	2.00e-12	65.50
IUUC-Olu-087597	Ostreococcus lucimarinus	38.46	5.00e-11	60.50
IUUC-Oga-088005	Otolemur garnettii	54.76	7.00e-08	50.40
IUUC-Oar-089711	Ovis aries	52.38	3.00e-07	48.10
IUUC-Ptr-090781	Pan troglodytes	54.76	8.00e-08	50.10
IUUC-Pan-091716	Papio anubis	54.76	7.00e-08	50.10
IUUC-Psi-093261	Pelodiscus sinensis	26.22	3.00e-11	61.20
IUUC-Pno-094908	Phaeosphaeria nodorum	45.55	3.00e-32	130.00
IUUC-Ppa-095891	Physcomitrella patens	46.03	1.00e-13	69.30
IUUC-Pfo-096638	Poecilia formosa	27.23	3.00e-14	71.60
IUUC-Pab-097891	Pongo abelii	54.76	8.00e-08	50.10
IUUC-Pop-099077	Populus trichocarpa	36.62	3.00e-14	71.20
IUUC-Pca-100227	Procavia capensis	54.76	8.00e-08	50.10
IUUC-Ppe-101590	Prunus persica	37.88	6.00e-14	70.10
IUUC-Pva-102513	Pteropus vampyrus	52.38	5.00e-07	47.80
IUUC-Pgr-103261	Puccinia graminis	40.00	2.00e-29	121.00
IUUC-Ptt-103817	Puccinia triticina	39.21	1.00e-27	115.00
IUUC-Pte-104090	Pyrenophora teres	44.98	6.00e-35	139.00
IUUC-Pyt-104472	Pyrenophora triticirepentis	43.75	2.00e-32	131.00
IUUC-Rno-104908	Rattus norvegicus	28.08	7.00e-09	53.50
IUUC-Sce-106332	Saccharomyces cerevisiae	44.55	1.00e-43	168.00
IUUC-Sha-106964	Sarcophilus harrisii	41.67	2.00e-10	60.10
IUUC-Ssl-108425	Sclerotinia sclerotiorum	82.61	8.00e-19	85.50
IUUC-Smo-108910	Selaginella moellendorffii	46.27	8.00e-16	76.30
IUUC-Sit-110381	Setaria italica	44.29	8.00e-16	76.60
IUUC-Sly-111731	Solanum lycopersicum	40.85	9.00e-15	73.20
IUUC-Stu-112263	Solanum tuberosum	40.85	3.00e-15	74.70
IUUC-Sar-113198	Sorex araneus	37.50	8.00e-09	54.70
IUUC-Sbi-114273	Sorghum bicolor	44.29	9.00e-16	76.60
IUUC-Sre-115081	Sporisorium reilianum	36.91	2.00e-33	134.00
IUUC-Ssc-115820	Sus scrofa	52.38	3.00e-07	48.10
IUUC-Tru-118652	Takifugu rubripes	36.11	5.00e-09	53.90
IUUC-Tsy-119596	Tarsius syrichta	52.38	3.00e-07	48.10
IUUC-Tni-119780	Tetraodon nigroviridis	24.66	1.00e-10	59.30
IUUC-Tca-121577	Theobroma cacao	46.77	9.00e-13	67.00
IUUC-Tre-122085	Trichoderma reesei	41.92	2.00e-29	121.00
IUUC-Tvi-122381	Trichoderma virens	40.85	4.00e-34	136.00
IUUC-Tae-125468	Triticum aestivum	44.29	8.00e-16	76.60
IUUC-Tur-126783	Triticum urartu	44.29	7.00e-16	76.60
IUUC-Tme-127116	Tuber melanosporum	46.95	5.00e-44	169.00
IUUC-Tbe-127897	Tupaia belangeri	37.50	7.00e-09	54.70
IUUC-Ttr-128630	Tursiops truncatus	37.50	5.00e-07	47.40
IUUC-Uma-129639	Ustilago maydis	38.20	1.00e-35	141.00
IUUC-Vda-129991	Verticillium dahliae	39.22	2.00e-34	138.00
IUUC-Vpa-130633	Vicugna pacos	54.76	2.00e-08	51.20
IUUC-Vvi-131493	Vitis vinifera	33.56	3.00e-15	75.10
IUUC-Xtr-132680	Xenopus tropicalis	42.25	5.00e-11	61.60
IUUC-Xma-134155	Xiphophorus maculatus	26.58	1.00e-11	62.80
IUUC-Yli-134630	Yarrowia lipolytica	40.35	1.00e-40	158.00
IUUC-Zma-135583	Zea mays	28.29	1.00e-16	79.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence