iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117849

Ensembl Protein ID

ENSTRUP00000014545.1

UniProt Accession

H2SQ58; H2SQ58_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

src; LOC101065281

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000005980.1	ENSTRUT00000014613.1	ENSTRUP00000014545.1
ENSTRUG00000005980.1	ENSTRUT00000014614.1	ENSTRUP00000014546.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-11	45.3	90	150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi....ekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ +  +L+++kG+ ++++    + ++ +++W+ + + ++g +G +P+n+v+ 
   Q: 90   TFVALYDYESRTASDLSFRKGERLQIVnntrKLNCREGDWWLARSLTTGDSGYIPSNYVAP 150
           6789***********************655555678**********************975 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGGHKSKPKD VGQRSRSLDG TLSSGGGAGG HHHNSNQQSL TPNRSPTVEG GLGGGQSMPN 60
NAELALFGGV DNNSLTAPSR ITLAAGGVTT FVALYDYESR TASDLSFRKG ERLQIVNNTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGGAC ATAAGAGTAA GCCCAAAGAT GTAGGCCAAC GAAGTCGCAG CCTTGATGGA 60
ACCCTCAGCT CTGGGGGAGG GGCTGGCGGC CACCACCACA ACTCCAATCA ACAGTCTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0070851--F:growth factor receptor binding
GO:0051427--F:hormone receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0045453--P:bone resorption
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0036035--P:osteoclast development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0048920--P:posterior lateral line neuromast primordium migration
GO:0050847--P:progesterone receptor signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042127--P:regulation of cell proliferation
GO:0071801--P:regulation of podosome assembly
GO:0043114--P:regulation of vascular permeability
GO:0001878--P:response to yeast

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	81.68	0.00e+00	908.00
IUUC-Aca-004237	Anolis carolinensis	80.87	0.00e+00	900.00
IUUC-Bta-012982	Bos taurus	80.84	0.00e+00	903.00
IUUC-Bdi-014324	Brachypodium distachyon	29.68	5.00e-25	109.00
IUUC-Cja-019995	Callithrix jacchus	82.05	0.00e+00	914.00
IUUC-Cfa-020060	Canis familiaris	81.68	0.00e+00	908.00
IUUC-Cpo-021557	Cavia porcellus	80.25	0.00e+00	899.00
IUUC-Csa-023711	Chlorocebus sabaeus	82.05	0.00e+00	912.00
IUUC-Dre-028491	Danio rerio	87.73	0.00e+00	956.00
IUUC-Dno-029651	Dasypus novemcinctus	80.00	0.00e+00	895.00
IUUC-Ete-033170	Echinops telfairi	88.43	0.00e+00	853.00
IUUC-Eca-033970	Equus caballus	79.89	0.00e+00	870.00
IUUC-Fca-036113	Felis catus	81.68	0.00e+00	908.00
IUUC-Fal-036785	Ficedula albicollis	82.05	0.00e+00	918.00
IUUC-Gga-040899	Gallus gallus	80.92	0.00e+00	900.00
IUUC-Gac-042332	Gasterosteus aculeatus	92.65	0.00e+00	1023.00
IUUC-Gma-043938	Glycine max	32.56	6.00e-23	103.00
IUUC-Hsa-046192	Homo sapiens	81.68	0.00e+00	913.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	81.68	0.00e+00	913.00
IUUC-Lch-049892	Latimeria chalumnae	81.62	0.00e+00	910.00
IUUC-Loc-052812	Lepisosteus oculatus	87.07	0.00e+00	961.00
IUUC-Laf-053977	Loxodonta africana	82.42	0.00e+00	923.00
IUUC-Mcc-055159	Macaca mulatta	80.43	0.00e+00	903.00
IUUC-Mga-060135	Meleagris gallopavo	81.65	0.00e+00	915.00
IUUC-Mmr-061168	Microcebus murinus	80.22	0.00e+00	913.00
IUUC-Mdo-063030	Monodelphis domestica	80.40	0.00e+00	909.00
IUUC-Mmu-063893	Mus musculus	81.32	0.00e+00	919.00
IUUC-Mpu-066411	Mustela putorius furo	81.68	0.00e+00	908.00
IUUC-Mlu-068139	Myotis lucifugus	81.68	0.00e+00	919.00
IUUC-Nle-070178	Nomascus leucogenys	80.04	0.00e+00	867.00
IUUC-Ont-072666	Oreochromis niloticus	92.46	0.00e+00	979.00
IUUC-Ocu-074403	Oryctolagus cuniculus	81.54	0.00e+00	906.00
IUUC-Ogl-077331	Oryza glaberrima	33.62	6.00e-24	106.00
IUUC-Ogu-078962	Oryza glumaepatula	34.04	2.00e-24	107.00
IUUC-Oin-079172	Oryza indica	34.04	2.00e-24	107.00
IUUC-Olo-080286	Oryza longistaminata	34.04	2.00e-24	107.00
IUUC-Ome-081400	Oryza meridionalis	34.04	2.00e-24	108.00
IUUC-Oru-084741	Oryza rufipogon	35.16	2.00e-24	107.00
IUUC-Osa-085779	Oryza sativa	34.89	3.00e-24	107.00
IUUC-Ola-086953	Oryzias latipes	91.91	0.00e+00	989.00
IUUC-Oga-088493	Otolemur garnettii	81.68	0.00e+00	915.00
IUUC-Ptr-091050	Pan troglodytes	81.68	0.00e+00	913.00
IUUC-Pan-091862	Papio anubis	81.50	0.00e+00	899.00
IUUC-Psi-093071	Pelodiscus sinensis	80.77	0.00e+00	903.00
IUUC-Pab-097902	Pongo abelii	80.25	0.00e+00	905.00
IUUC-Rno-105847	Rattus norvegicus	81.17	0.00e+00	918.00
IUUC-Sha-107539	Sarcophilus harrisii	80.77	0.00e+00	900.00
IUUC-Sbi-114480	Sorghum bicolor	29.88	2.00e-24	107.00
IUUC-Ssc-115762	Sus scrofa	81.57	0.00e+00	918.00
IUUC-Ttr-128702	Tursiops truncatus	76.74	0.00e+00	841.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence