iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050663

Ensembl Protein ID

ENSLACP00000008307.2

UniProt Accession

H3AF86; H3AF86_LATCH

Genbank Protein ID

ENSLACP00000008307

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AFYH01175270

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000007353.2	ENSLACT00000008373.2	ENSLACP00000008307.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-135	452.0	550	882

Active Site

Position(s)	Description	Evidence
851	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 550  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLAYFRFIGRFIAMALYHGKFIDT 637
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGeni+Vt+eNkeeY+ ++++
   Q: 638  GFTLPFYKRMLNKKPTLKDLESIDPEFYNSILWIKEN---NLEECGLELYFAQDMEILGKVTTHELKEGGENIRVTEENKEEYIMRLTD 723
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 724  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRH-YTKTSKQIQWFWQVVKEMDNEKRIRLLQFV 811
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+++lkekLlyA+eet+gF++
   Q: 812  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYDQLKEKLLYAVEETEGFGQ 882
           *********************************************************************96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MASASSSRAG AEPASDRSQL TLKVISAKPK INNRQSRINS YVEVTPDGLA NEAKKTGKRS 60
GNPELQWNEN LTVNVTPQSR LDLKLWSCHT LRNELFGSAS VDVCETLKNN NGKMENIHLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCTTCCTG TTTGGCTGGG TCGGAGGGAG TTTCCGATCA GGTGAGGCGG AAGTTCAGTG 60
GCTGAAGGGA GCTGCCGAAG TGACGGAGAA AGAGGAGACG GGGCAGCCGG GACAGGTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

KEGG

lcm:102355333

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	78.28	0.00e+00	1353.00
IUUC-Apl-003912	Anas platyrhynchos	70.90	0.00e+00	1139.00
IUUC-Aca-004291	Anolis carolinensis	76.28	0.00e+00	1342.00
IUUC-Bta-013231	Bos taurus	78.57	0.00e+00	1342.00
IUUC-Cja-019455	Callithrix jacchus	78.23	0.00e+00	1369.00
IUUC-Cfa-021017	Canis familiaris	78.60	0.00e+00	1345.00
IUUC-Cpo-021988	Cavia porcellus	78.69	0.00e+00	1370.00
IUUC-Csa-023549	Chlorocebus sabaeus	78.39	0.00e+00	1379.00
IUUC-Dre-028513	Danio rerio	92.82	0.00e+00	1146.00
IUUC-Dno-028976	Dasypus novemcinctus	77.36	0.00e+00	1367.00
IUUC-Dor-030176	Dipodomys ordii	78.00	0.00e+00	1322.00
IUUC-Eca-033949	Equus caballus	78.71	0.00e+00	1354.00
IUUC-Eeu-034529	Erinaceus europaeus	82.76	0.00e+00	999.00
IUUC-Fca-036236	Felis catus	78.57	0.00e+00	1368.00
IUUC-Fal-036948	Ficedula albicollis	95.29	0.00e+00	1167.00
IUUC-Gmo-038842	Gadus morhua	89.77	0.00e+00	1073.00
IUUC-Gga-040617	Gallus gallus	74.23	0.00e+00	1308.00
IUUC-Gac-041338	Gasterosteus aculeatus	71.35	0.00e+00	1269.00
IUUC-Ggo-045278	Gorilla gorilla	78.74	0.00e+00	1384.00
IUUC-Hsa-046148	Homo sapiens	78.74	0.00e+00	1387.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	93.66	0.00e+00	1067.00
IUUC-Loc-052604	Lepisosteus oculatus	77.75	0.00e+00	1366.00
IUUC-Laf-053944	Loxodonta africana	78.83	0.00e+00	1368.00
IUUC-Mcc-055655	Macaca mulatta	78.39	0.00e+00	1382.00
IUUC-Meu-055953	Macropus eugenii	79.64	0.00e+00	1005.00
IUUC-Mga-060190	Meleagris gallopavo	74.92	0.00e+00	1332.00
IUUC-Mmr-060896	Microcebus murinus	78.46	0.00e+00	1356.00
IUUC-Mdo-062536	Monodelphis domestica	78.60	0.00e+00	1391.00
IUUC-Mmu-064017	Mus musculus	78.69	0.00e+00	1359.00
IUUC-Mpu-066608	Mustela putorius furo	74.66	0.00e+00	1291.00
IUUC-Mlu-067623	Myotis lucifugus	76.46	0.00e+00	1311.00
IUUC-Nle-069496	Nomascus leucogenys	76.83	0.00e+00	1338.00
IUUC-Opr-071054	Ochotona princeps	94.71	0.00e+00	1141.00
IUUC-Ont-071279	Oreochromis niloticus	76.33	0.00e+00	1311.00
IUUC-Oan-073512	Ornithorhynchus anatinus	76.46	0.00e+00	1339.00
IUUC-Ocu-074271	Oryctolagus cuniculus	78.69	0.00e+00	1358.00
IUUC-Ola-087237	Oryzias latipes	70.25	0.00e+00	1249.00
IUUC-Oga-088164	Otolemur garnettii	79.26	0.00e+00	1366.00
IUUC-Oar-089698	Ovis aries	78.57	0.00e+00	1341.00
IUUC-Ptr-091306	Pan troglodytes	77.36	0.00e+00	1353.00
IUUC-Pan-092814	Papio anubis	75.11	0.00e+00	1300.00
IUUC-Pfo-096709	Poecilia formosa	73.25	0.00e+00	1275.00
IUUC-Pab-098494	Pongo abelii	77.36	0.00e+00	1352.00
IUUC-Pca-100596	Procavia capensis	70.08	0.00e+00	1177.00
IUUC-Pva-103154	Pteropus vampyrus	75.92	0.00e+00	1290.00
IUUC-Rno-104954	Rattus norvegicus	79.22	0.00e+00	1204.00
IUUC-Sha-106781	Sarcophilus harrisii	78.87	0.00e+00	1407.00
IUUC-Ssc-116307	Sus scrofa	70.15	0.00e+00	1216.00
IUUC-Tgu-116530	Taeniopygia guttata	70.34	0.00e+00	1094.00
IUUC-Tru-118287	Takifugu rubripes	91.39	0.00e+00	1084.00
IUUC-Tsy-119097	Tarsius syrichta	65.94	0.00e+00	979.00
IUUC-Tni-120801	Tetraodon nigroviridis	72.29	0.00e+00	1237.00
IUUC-Tbe-127793	Tupaia belangeri	69.01	0.00e+00	1149.00
IUUC-Ttr-128275	Tursiops truncatus	94.71	0.00e+00	1153.00
IUUC-Uma-129332	Ustilago maydis	45.78	1.00e-141	497.00
IUUC-Xtr-132866	Xenopus tropicalis	81.55	0.00e+00	1128.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence