iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004155

Ensembl Protein ID

ENSAPLP00000010236.1

UniProt Accession

U3ISL3; U3ISL3_ANAPL

Genbank Protein ID

ENSAPLP00000010236

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01076797

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000010476.1	ENSAPLT00000010945.1	ENSAPLP00000010236.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-126	421.9	416	752

Active Site

Position(s)	Description	Evidence
721	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGv.treflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dlkkrl+v+f+gEegld+gGv +re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++
   Q: 416  PKDLKKRLMVKFRGEEGLDYGGVaSREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYIN 503
           689*******************9459***********************************9.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
             ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v
   Q: 504  GGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYV 588
           ************************************99...9***8.****************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqF
   Q: 589  NWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQF 676
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 677  VTGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 752
           *******************************99999**************************************76 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

APEPFLVQNL LSARCKMAVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCAGAAC CCTTCTTGGT TCAAAACCTG CTTAGTGCTC GTTGTAAAAT GGGTGGGTTC 60
TGAAACAATG GCAGCAAAAT TCTGTTTTAG CACTTGTGTG AGCATGTAAT ATAGAGACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	88.87	0.00e+00	1378.00
IUUC-Aca-005238	Anolis carolinensis	93.40	0.00e+00	1433.00
IUUC-Ame-010901	Astyanax mexicanus	87.47	0.00e+00	1353.00
IUUC-Bta-013221	Bos taurus	87.17	0.00e+00	1322.00
IUUC-Cja-018985	Callithrix jacchus	93.40	0.00e+00	1454.00
IUUC-Cfa-020568	Canis familiaris	93.84	0.00e+00	1431.00
IUUC-Cpo-022531	Cavia porcellus	92.74	0.00e+00	1446.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.08	0.00e+00	1432.00
IUUC-Cho-024963	Choloepus hoffmanni	76.26	0.00e+00	906.00
IUUC-Dre-028341	Danio rerio	87.62	0.00e+00	1362.00
IUUC-Dno-029705	Dasypus novemcinctus	93.94	0.00e+00	1417.00
IUUC-Dme-031740	Drosophila melanogaster	70.62	4.00e-175	608.00
IUUC-Eca-034125	Equus caballus	94.62	0.00e+00	1446.00
IUUC-Fca-035905	Felis catus	92.69	0.00e+00	1418.00
IUUC-Fal-037336	Ficedula albicollis	95.66	0.00e+00	1444.00
IUUC-Gmo-039486	Gadus morhua	78.14	0.00e+00	860.00
IUUC-Gga-040218	Gallus gallus	96.67	0.00e+00	1503.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.75	0.00e+00	1252.00
IUUC-Ggo-045408	Gorilla gorilla	88.42	0.00e+00	1340.00
IUUC-Hsa-045878	Homo sapiens	93.54	0.00e+00	1456.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	94.60	0.00e+00	1437.00
IUUC-Loc-052628	Lepisosteus oculatus	82.38	0.00e+00	1338.00
IUUC-Laf-053644	Loxodonta africana	88.90	0.00e+00	1361.00
IUUC-Mcc-055479	Macaca mulatta	85.49	0.00e+00	1283.00
IUUC-Mga-059723	Meleagris gallopavo	92.49	0.00e+00	1432.00
IUUC-Mdo-063005	Monodelphis domestica	94.53	0.00e+00	1459.00
IUUC-Mmu-063634	Mus musculus	92.68	0.00e+00	1412.00
IUUC-Mpu-065898	Mustela putorius furo	93.03	0.00e+00	1419.00
IUUC-Mlu-067584	Myotis lucifugus	93.87	0.00e+00	1444.00
IUUC-Nle-069033	Nomascus leucogenys	95.02	0.00e+00	1450.00
IUUC-Ont-072265	Oreochromis niloticus	82.96	0.00e+00	1289.00
IUUC-Oan-073621	Ornithorhynchus anatinus	90.12	0.00e+00	1425.00
IUUC-Ocu-073960	Oryctolagus cuniculus	93.69	0.00e+00	1419.00
IUUC-Oga-088579	Otolemur garnettii	93.54	0.00e+00	1456.00
IUUC-Oar-090396	Ovis aries	90.84	0.00e+00	1345.00
IUUC-Ptr-091624	Pan troglodytes	93.54	0.00e+00	1456.00
IUUC-Pan-092479	Papio anubis	94.14	0.00e+00	1448.00
IUUC-Psi-094074	Pelodiscus sinensis	95.16	0.00e+00	1134.00
IUUC-Pfo-097203	Poecilia formosa	81.94	0.00e+00	1263.00
IUUC-Pab-097540	Pongo abelii	93.10	0.00e+00	1384.00
IUUC-Pca-100379	Procavia capensis	72.47	0.00e+00	632.00
IUUC-Rno-105396	Rattus norvegicus	92.68	0.00e+00	1413.00
IUUC-Sha-107216	Sarcophilus harrisii	95.70	0.00e+00	1464.00
IUUC-Ssc-116413	Sus scrofa	93.75	0.00e+00	1385.00
IUUC-Tgu-116723	Taeniopygia guttata	95.56	0.00e+00	1452.00
IUUC-Tru-117843	Takifugu rubripes	79.66	0.00e+00	1242.00
IUUC-Tsy-119455	Tarsius syrichta	93.05	0.00e+00	1352.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.28	0.00e+00	1215.00
IUUC-Tbe-127879	Tupaia belangeri	80.86	0.00e+00	1181.00
IUUC-Ttr-128423	Tursiops truncatus	93.26	0.00e+00	1366.00
IUUC-Xtr-132237	Xenopus tropicalis	88.74	0.00e+00	1379.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence