iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074365

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02064501

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000022810.2	ENSOCUT00000025241.2	ENSOCUP00000017084.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-89	299.5	359	701

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 359  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-NKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 443
           9*****************************.88888875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k        +         s  +e+++ +  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 444  DAHEFLIAILDVLHRHSKD-------D---------SVGQESSNSNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 516
           *****************22.......2.........2334578999*****************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 517  CATFSPqntemadstmsradhipgipSLTDCLQWFTRPEDLGSSAKIKCSSCQSYQESTKQLTMKKLPMVACFHLKRF--EHVGKQRRK 603
           977666899999******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 604  INTFISFPLELDMTPFLASTKESRMKecqpstdcvsnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 690
           ****************999665555578888888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 691  -SEGYLLFYHKQ 701
           .********985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAQVPEASSF SGSVACWSSR VGGGASPEKA VEKAGKMEEE AVGAAKAYAG REAEMKVESL 60
EELKPAAKDN LTWSGSGGDE KVLPSTPPYR YSSSSPVCPR RKPRPRPQPG ARSRGPPGNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCAGG TTCCAGAAGC TTCCTCGTTC TCCGGCTCCG TGGCTTGCTG GAGCTCGCGA 60
GTGGGGGGAG GAGCCTCGCC CGAAAAGGCG GTTGAGAAGG CGGGGAAAAT GGAGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100345883

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.71	4.00e-63	236.00
IUUC-Aml-001480	Ailuropoda melanoleuca	92.21	0.00e+00	971.00
IUUC-Afl-008464	Aspergillus flavus	31.85	6.00e-53	201.00
IUUC-Ang-009694	Aspergillus niger	31.31	1.00e-57	217.00
IUUC-Aor-010035	Aspergillus oryzae	34.21	1.00e-37	149.00
IUUC-Ate-010382	Aspergillus terreus	32.48	5.00e-52	197.00
IUUC-Bol-016509	Brassica oleracea	36.48	9.00e-73	268.00
IUUC-Bra-016962	Brassica rapa	36.08	8.00e-73	267.00
IUUC-Cja-019402	Callithrix jacchus	90.51	0.00e+00	699.00
IUUC-Csa-023824	Chlorocebus sabaeus	92.78	0.00e+00	976.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	28.98	2.00e-55	210.00
IUUC-Cne-027085	Cryptococcus neoformans	30.94	1.00e-60	227.00
IUUC-Eca-033872	Equus caballus	91.67	0.00e+00	963.00
IUUC-Fca-035534	Felis catus	92.01	0.00e+00	982.00
IUUC-Ggo-045109	Gorilla gorilla	92.31	0.00e+00	954.00
IUUC-Hsa-045765	Homo sapiens	93.28	0.00e+00	994.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	92.99	0.00e+00	929.00
IUUC-Mcc-055420	Macaca mulatta	92.29	0.00e+00	1007.00
IUUC-Mor-057103	Magnaporthe oryzae	30.96	5.00e-55	208.00
IUUC-Mla-059185	Melampsora laricipopulina	32.77	1.00e-41	164.00
IUUC-Mmr-061690	Microcebus murinus	92.68	0.00e+00	997.00
IUUC-Mmu-063435	Mus musculus	81.13	0.00e+00	838.00
IUUC-Mac-065419	Musa acuminata	33.47	2.00e-72	266.00
IUUC-Mpu-065679	Mustela putorius furo	91.65	0.00e+00	947.00
IUUC-Mlu-067084	Myotis lucifugus	90.38	0.00e+00	979.00
IUUC-Nle-069859	Nomascus leucogenys	93.55	0.00e+00	986.00
IUUC-Ptr-091479	Pan troglodytes	93.10	0.00e+00	996.00
IUUC-Pan-091707	Papio anubis	92.59	0.00e+00	973.00
IUUC-Pab-097894	Pongo abelii	93.96	0.00e+00	997.00
IUUC-Pgr-103657	Puccinia graminis	28.54	7.00e-38	151.00
IUUC-Rno-105644	Rattus norvegicus	79.96	0.00e+00	835.00
IUUC-Sar-113426	Sorex araneus	72.32	0.00e+00	856.00
IUUC-Ssc-115500	Sus scrofa	83.80	0.00e+00	1002.00
IUUC-Tsy-119413	Tarsius syrichta	90.74	0.00e+00	977.00
IUUC-Tre-122139	Trichoderma reesei	31.81	4.00e-53	202.00
IUUC-Uma-129455	Ustilago maydis	27.02	7.00e-58	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence