iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091707

Ensembl Protein ID

ENSPANP00000002438.1

UniProt Accession

A0A096MRN6; A0A096MRN6_PAPAN

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000010398.1	ENSPANT00000005632.1	ENSPANP00000002438.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-90	302.9	363	705

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 363  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 447
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k                  s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 448  DAHEFLIAILDVLHRHSKD----------------DSGVQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 520
           *****************22................2233466899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 521  CATFDSqnperadgtvsrdhhipgipSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 607
           9877668999********************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 608  INTFISFPLELDMTPFLASTKESRMKegqppadcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 694
           ****************999666655578899999999**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 695  -SEGYLLFYHKQ 705
           .********985 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAQVPETSLP SGSGARWISG GGGGASPEEA VEKAGKMEEA AAGATKASSG REAEEMKLEP 60
LQEPKPVPEE NLTWTSSGGD EKVLPSIPLR CHSSSSPVCP RRKPRPRPQP RARSRSQPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAGG TTCCAGAAAC TTCTTTGCCC TCCGGCTCTG GGGCCCGCTG GATCTCCGGA 60
GGTGGGGGAG GAGCCTCTCC TGAGGAGGCG GTTGAGAAGG CGGGGAAAAT GGAGGAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	92.59	0.00e+00	986.00
IUUC-Ang-009694	Aspergillus niger	31.32	2.00e-56	213.00
IUUC-Bra-016962	Brassica rapa	36.94	3.00e-73	269.00
IUUC-Cja-019402	Callithrix jacchus	96.15	0.00e+00	746.00
IUUC-Csa-023824	Chlorocebus sabaeus	99.81	0.00e+00	1060.00
IUUC-Eca-033872	Equus caballus	92.99	0.00e+00	984.00
IUUC-Fca-035534	Felis catus	92.38	0.00e+00	997.00
IUUC-Ggo-045109	Gorilla gorilla	96.16	0.00e+00	1001.00
IUUC-Hsa-045765	Homo sapiens	97.75	0.00e+00	1119.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	92.99	0.00e+00	945.00
IUUC-Mcc-055420	Macaca mulatta	99.63	0.00e+00	1098.00
IUUC-Mmr-061690	Microcebus murinus	93.81	0.00e+00	1018.00
IUUC-Mmu-063435	Mus musculus	79.66	0.00e+00	822.00
IUUC-Mpu-065679	Mustela putorius furo	93.17	0.00e+00	975.00
IUUC-Mlu-067084	Myotis lucifugus	91.11	0.00e+00	996.00
IUUC-Nle-069859	Nomascus leucogenys	98.29	0.00e+00	1042.00
IUUC-Ocu-074365	Oryctolagus cuniculus	92.06	0.00e+00	962.00
IUUC-Ptr-091479	Pan troglodytes	97.33	0.00e+00	1163.00
IUUC-Pab-097894	Pongo abelii	98.30	0.00e+00	1048.00
IUUC-Rno-105644	Rattus norvegicus	78.87	0.00e+00	833.00
IUUC-Sar-113426	Sorex araneus	79.60	0.00e+00	832.00
IUUC-Ssc-115500	Sus scrofa	91.12	0.00e+00	970.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence