iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021414

Ensembl Protein ID

ENSCPOP00000010891.2

UniProt Accession

H0VKP7; H0VKP7_CAVPO

Genbank Protein ID

ENSCPOP00000010891

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AAKN02036001

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000012109.3	ENSCPOT00000012225.2	ENSCPOP00000010891.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.80e-10	38.5	213	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 213  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 259
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MLGQQQQQLY SSAALLTGDR SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 60
KEIDDVYEKY KKEDDSNQKK RLQQHLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAGGGC AACAGCAGCA GCAACTGTAC TCGTCGGCCG CGCTGCTGAC GGGCGACCGG 60
AGCCGGCTTC TCACCTGCTA CGTGCAGGAC TATCTCGAGT GTGTGGAGTC GCTGCCTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	96.79	5.00e-120	423.00
IUUC-Apl-003705	Anas platyrhynchos	87.00	1.00e-89	322.00
IUUC-Aca-004990	Anolis carolinensis	79.92	3.00e-96	344.00
IUUC-Ame-011426	Astyanax mexicanus	69.71	3.00e-83	301.00
IUUC-Bta-012721	Bos taurus	96.11	5.00e-119	420.00
IUUC-Cja-018960	Callithrix jacchus	96.21	2.00e-104	371.00
IUUC-Cfa-020869	Canis familiaris	96.43	1.00e-119	421.00
IUUC-Csa-023304	Chlorocebus sabaeus	96.07	2.00e-110	391.00
IUUC-Dre-028562	Danio rerio	69.55	2.00e-88	318.00
IUUC-Dno-029945	Dasypus novemcinctus	96.21	2.00e-113	401.00
IUUC-Dor-030141	Dipodomys ordii	95.71	8.00e-117	412.00
IUUC-Ete-032709	Echinops telfairi	94.35	9.00e-127	446.00
IUUC-Eca-033432	Equus caballus	97.06	3.00e-118	417.00
IUUC-Eeu-035285	Erinaceus europaeus	95.61	1.00e-88	318.00
IUUC-Fca-036467	Felis catus	96.97	4.00e-114	403.00
IUUC-Fal-036700	Ficedula albicollis	86.22	2.00e-89	321.00
IUUC-Gmo-038748	Gadus morhua	62.32	4.00e-84	304.00
IUUC-Gga-040175	Gallus gallus	86.55	1.00e-89	322.00
IUUC-Gac-041403	Gasterosteus aculeatus	63.87	2.00e-89	322.00
IUUC-Hsa-045837	Homo sapiens	96.07	2.00e-110	391.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.50	7.00e-121	426.00
IUUC-Lch-049965	Latimeria chalumnae	79.39	4.00e-98	350.00
IUUC-Laf-053353	Loxodonta africana	94.22	3.00e-98	350.00
IUUC-Mcc-055155	Macaca mulatta	95.40	5.00e-71	259.00
IUUC-Meu-056470	Macropus eugenii	91.34	4.00e-109	387.00
IUUC-Mga-059570	Meleagris gallopavo	86.55	7.00e-89	319.00
IUUC-Mmr-061385	Microcebus murinus	96.43	7.00e-111	392.00
IUUC-Mdo-062144	Monodelphis domestica	91.41	2.00e-110	392.00
IUUC-Mmu-063215	Mus musculus	95.37	4.00e-118	417.00
IUUC-Mpu-065749	Mustela putorius furo	96.23	3.00e-98	350.00
IUUC-Nle-069968	Nomascus leucogenys	95.26	1.00e-79	288.00
IUUC-Ont-071524	Oreochromis niloticus	66.67	1.00e-86	312.00
IUUC-Ocu-074870	Oryctolagus cuniculus	95.76	2.00e-118	418.00
IUUC-Ola-087400	Oryzias latipes	86.59	2.00e-43	168.00
IUUC-Oga-088336	Otolemur garnettii	95.05	9.00e-109	386.00
IUUC-Oar-090136	Ovis aries	96.67	2.00e-117	414.00
IUUC-Ptr-091348	Pan troglodytes	95.79	3.00e-80	291.00
IUUC-Pan-092819	Papio anubis	96.07	2.00e-110	391.00
IUUC-Pfo-096633	Poecilia formosa	65.17	1.00e-81	296.00
IUUC-Pab-098346	Pongo abelii	95.71	6.00e-110	390.00
IUUC-Pca-100278	Procavia capensis	94.09	6.00e-115	406.00
IUUC-Pva-103190	Pteropus vampyrus	96.97	4.00e-114	404.00
IUUC-Rno-104940	Rattus norvegicus	95.45	1.00e-112	398.00
IUUC-Sha-107533	Sarcophilus harrisii	91.41	2.00e-111	395.00
IUUC-Sar-113630	Sorex araneus	95.61	8.00e-89	319.00
IUUC-Ssc-115734	Sus scrofa	96.97	5.00e-114	403.00
IUUC-Tgu-117034	Taeniopygia guttata	86.22	1.00e-89	322.00
IUUC-Tru-118168	Takifugu rubripes	60.34	4.00e-81	294.00
IUUC-Tsy-119494	Tarsius syrichta	96.32	1.00e-80	292.00
IUUC-Tni-120100	Tetraodon nigroviridis	60.89	6.00e-78	283.00
IUUC-Ttr-128442	Tursiops truncatus	97.07	5.00e-90	323.00
IUUC-Vpa-130063	Vicugna pacos	96.07	4.00e-119	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence