iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050294

Ensembl Protein ID

ENSLACP00000003101.1

UniProt Accession

H3A0D0; H3A0D0_LATCH

Genbank Protein ID

ENSLACP00000003101

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01035442

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000002778.1	ENSLACT00000003131.1	ENSLACP00000003101.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-98	330.7	263	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++++                                           
   Q: 263  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTANgkpkmsgpatcgsgksdkmgspgkqsmlarlnsgtsasrtlel 351
           7******************************8887444444444446677999999999999999999999999999999999999999 PP
   S: 43   ......kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkse 125
                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         e+e+++++ 
   Q: 352  iqpkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWRLIPAFRGYDQQDAQEFLCELLDKVQQEL---------ESEGTKRRI 431
           99999888889************************************************************.........678889999 PP
   S: 126  lsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............slqdcLesftkeeeleg 202
           l   +++k +k+  ++++++F+gql sq++cl+c+ +s++ epf+dlsl++p++ ++ ++            +l+++L++ft++e leg
   Q: 432  LIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCLTCNYKSNTIEPFWDLSLEFPERYHSVEKgavgtntqqthcTLTEMLAKFTETEALEG 520
           9999************************************************9998877799**************************9 PP
   S: 203  enkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkY 278
           +  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+ ++++ ++ +  + +Y
   Q: 521  RI-YACDQCNSKRRksspkplvlseAQKRLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVIFDQVLNMEPYYCRDSLSSLDkaSFIY 607
           65.*******9999999*******************************997.8889****************888766665444599** PP
   S: 279  eLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 608  DLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 665
           ************************9999********************...********98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQNHSILN PQKWHCMDCA TTESVWACLK CSHVACGRYM EEHALKHFQE 60
TRHPLAMEVN DLYVFCYFCE DYVLNDNPEG DLKLLRSTLS AIKNQKRNPL LRSSRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GTAAACATGT GGGGCGGCTT CGTCTCGCCC AGAATCACTC CATTCTTAAC 60
CCCCAGAAGT GGCACTGCAT GGACTGCGCC ACGACGGAGT CCGTCTGGGC CTGCCTCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102356188

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	83.60	0.00e+00	1140.00
IUUC-Aca-005278	Anolis carolinensis	82.54	0.00e+00	1138.00
IUUC-Bta-012911	Bos taurus	75.47	0.00e+00	959.00
IUUC-Cja-019171	Callithrix jacchus	75.93	0.00e+00	997.00
IUUC-Cfa-020408	Canis familiaris	75.36	0.00e+00	974.00
IUUC-Cpo-022233	Cavia porcellus	71.24	0.00e+00	914.00
IUUC-Cho-025051	Choloepus hoffmanni	76.84	6.00e-156	543.00
IUUC-Cin-025587	Ciona intestinalis	47.36	1.00e-109	391.00
IUUC-Csv-025814	Ciona savignyi	43.24	2.00e-148	519.00
IUUC-Dno-029856	Dasypus novemcinctus	75.50	0.00e+00	982.00
IUUC-Eca-033851	Equus caballus	71.11	0.00e+00	875.00
IUUC-Fal-037290	Ficedula albicollis	79.22	0.00e+00	989.00
IUUC-Gmo-039249	Gadus morhua	78.44	9.00e-151	526.00
IUUC-Gga-040383	Gallus gallus	83.06	0.00e+00	837.00
IUUC-Gac-042595	Gasterosteus aculeatus	62.80	0.00e+00	808.00
IUUC-Ggo-044979	Gorilla gorilla	75.93	0.00e+00	992.00
IUUC-Hsa-046743	Homo sapiens	75.79	0.00e+00	990.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	74.64	0.00e+00	988.00
IUUC-Loc-051961	Lepisosteus oculatus	74.55	0.00e+00	690.00
IUUC-Mcc-055048	Macaca mulatta	76.22	0.00e+00	996.00
IUUC-Meu-055971	Macropus eugenii	68.33	2.00e-158	552.00
IUUC-Mdo-062073	Monodelphis domestica	82.01	0.00e+00	1122.00
IUUC-Mmu-064095	Mus musculus	74.28	0.00e+00	974.00
IUUC-Mlu-067090	Myotis lucifugus	73.91	0.00e+00	946.00
IUUC-Nle-069486	Nomascus leucogenys	76.07	0.00e+00	994.00
IUUC-Opr-070563	Ochotona princeps	73.68	0.00e+00	968.00
IUUC-Ont-072103	Oreochromis niloticus	63.79	0.00e+00	821.00
IUUC-Ola-086413	Oryzias latipes	59.80	0.00e+00	749.00
IUUC-Oga-088862	Otolemur garnettii	75.64	0.00e+00	993.00
IUUC-Ptr-091525	Pan troglodytes	75.08	0.00e+00	892.00
IUUC-Pan-092363	Papio anubis	76.84	0.00e+00	976.00
IUUC-Psi-093353	Pelodiscus sinensis	84.63	0.00e+00	1141.00
IUUC-Pma-094155	Petromyzon marinus	59.18	6.00e-85	306.00
IUUC-Pfo-096413	Poecilia formosa	64.02	0.00e+00	830.00
IUUC-Pca-100449	Procavia capensis	75.18	0.00e+00	987.00
IUUC-Pva-102868	Pteropus vampyrus	74.21	0.00e+00	959.00
IUUC-Rno-105190	Rattus norvegicus	74.50	0.00e+00	972.00
IUUC-Sha-107337	Sarcophilus harrisii	82.32	0.00e+00	1113.00
IUUC-Sar-113561	Sorex araneus	85.71	2.00e-81	295.00
IUUC-Ssc-115735	Sus scrofa	74.93	0.00e+00	952.00
IUUC-Tgu-117025	Taeniopygia guttata	74.10	0.00e+00	910.00
IUUC-Tru-117585	Takifugu rubripes	65.02	0.00e+00	806.00
IUUC-Tsy-118814	Tarsius syrichta	75.21	0.00e+00	988.00
IUUC-Tni-120600	Tetraodon nigroviridis	64.19	0.00e+00	767.00
IUUC-Xtr-132090	Xenopus tropicalis	74.89	0.00e+00	981.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence