iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066207

Ensembl Protein ID

ENSMPUP00000007145.1

UniProt Accession

M3Y741; M3Y741_MUSPF

Genbank Protein ID

ENSMPUP00000007145

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01024628

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000007203.1	ENSMPUT00000007264.1	ENSMPUP00000007145.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.90e-97	325.5	272	676

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+           ++        +                                    
   Q: 272  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnrwlavtaSD--------Ktrspykhppitdtvyqmnecqekdtgsapsrhpsls 352
           7******************************8887666555422........1334455558888888888888888899999999999 PP
   S: 43   .....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkke 110
                                +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el   
   Q: 353  lglsggasksrkmeliqprepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQHEL--- 438
           99999988888888887777666677************************************************************... PP
   S: 111  knkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLe 192
                 e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L+
   Q: 439  ------ETTGTRLPALLPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGReitsqpcLVTEMLA 521
           ......67888888899999***********************************************9888766688888889****** PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ 
   Q: 522  KFTETEALEGKI-YVCDHCNSKRRrfssksvilteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRESL 608
           *********965.*******999999999*****9***********************998.7778********************998 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 609  KSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 676
           8876779***************************9999********************...********98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLTMDKCKHI GQLRLAQDHS ILNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQDSSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDMKLLRS MLSAIKSQNY QGTTRSGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAATCTCTCT GCTGAATGTG GAACCTTACT TGCCCAACTG CTAACTGAGG AAACCGAATT 60
CAAGGGGGAT AACCTGGATC TCACACCTAG GTTGCACCTC GGAAAGGAAA CTTTTTCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	95.78	0.00e+00	1391.00
IUUC-Apl-003673	Anas platyrhynchos	74.75	0.00e+00	1052.00
IUUC-Aca-004434	Anolis carolinensis	71.05	0.00e+00	1032.00
IUUC-Ame-010986	Astyanax mexicanus	64.00	0.00e+00	874.00
IUUC-Bta-012774	Bos taurus	89.03	0.00e+00	1288.00
IUUC-Cja-019619	Callithrix jacchus	88.64	0.00e+00	1273.00
IUUC-Cfa-020957	Canis familiaris	94.37	0.00e+00	1390.00
IUUC-Csa-023177	Chlorocebus sabaeus	88.78	0.00e+00	1277.00
IUUC-Cho-024877	Choloepus hoffmanni	88.66	0.00e+00	852.00
IUUC-Cin-025587	Ciona intestinalis	48.39	2.00e-107	383.00
IUUC-Csv-025814	Ciona savignyi	45.02	2.00e-155	543.00
IUUC-Dre-027878	Danio rerio	63.22	0.00e+00	840.00
IUUC-Dno-029832	Dasypus novemcinctus	91.42	0.00e+00	1337.00
IUUC-Ete-032627	Echinops telfairi	85.83	0.00e+00	1250.00
IUUC-Eca-033863	Equus caballus	84.63	0.00e+00	1221.00
IUUC-Eeu-035225	Erinaceus europaeus	84.69	0.00e+00	1211.00
IUUC-Fca-036288	Felis catus	94.23	0.00e+00	1375.00
IUUC-Fal-037207	Ficedula albicollis	74.61	0.00e+00	1016.00
IUUC-Gga-040457	Gallus gallus	74.23	0.00e+00	1016.00
IUUC-Gac-042595	Gasterosteus aculeatus	53.42	0.00e+00	702.00
IUUC-Ggo-044926	Gorilla gorilla	88.64	0.00e+00	1267.00
IUUC-Hsa-046079	Homo sapiens	88.22	0.00e+00	1265.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	90.17	0.00e+00	1295.00
IUUC-Lch-050260	Latimeria chalumnae	67.56	0.00e+00	931.00
IUUC-Loc-051981	Lepisosteus oculatus	76.98	0.00e+00	674.00
IUUC-Laf-054491	Loxodonta africana	88.39	0.00e+00	1214.00
IUUC-Mcc-055694	Macaca mulatta	88.64	0.00e+00	1274.00
IUUC-Mga-059523	Meleagris gallopavo	74.33	0.00e+00	1040.00
IUUC-Mmr-060885	Microcebus murinus	91.58	0.00e+00	1310.00
IUUC-Mdo-063018	Monodelphis domestica	79.32	0.00e+00	1113.00
IUUC-Mmu-064012	Mus musculus	78.65	0.00e+00	1087.00
IUUC-Mlu-066929	Myotis lucifugus	87.05	0.00e+00	1199.00
IUUC-Nle-069313	Nomascus leucogenys	79.06	0.00e+00	1097.00
IUUC-Opr-070375	Ochotona princeps	80.25	0.00e+00	1109.00
IUUC-Ont-071637	Oreochromis niloticus	63.55	0.00e+00	854.00
IUUC-Oan-073030	Ornithorhynchus anatinus	78.31	0.00e+00	842.00
IUUC-Ocu-074836	Oryctolagus cuniculus	86.06	0.00e+00	1225.00
IUUC-Oga-088367	Otolemur garnettii	91.30	0.00e+00	1291.00
IUUC-Oar-089953	Ovis aries	91.29	0.00e+00	1335.00
IUUC-Ptr-090980	Pan troglodytes	88.36	0.00e+00	1269.00
IUUC-Pan-092748	Papio anubis	89.33	0.00e+00	1287.00
IUUC-Psi-094078	Pelodiscus sinensis	76.08	0.00e+00	845.00
IUUC-Pfo-096413	Poecilia formosa	54.31	0.00e+00	728.00
IUUC-Pab-098514	Pongo abelii	88.78	0.00e+00	1274.00
IUUC-Pva-102984	Pteropus vampyrus	90.58	0.00e+00	1287.00
IUUC-Rno-106019	Rattus norvegicus	79.30	0.00e+00	1132.00
IUUC-Sha-106965	Sarcophilus harrisii	78.09	0.00e+00	1108.00
IUUC-Ssc-115299	Sus scrofa	92.12	0.00e+00	1355.00
IUUC-Tgu-117160	Taeniopygia guttata	74.85	0.00e+00	1017.00
IUUC-Tru-118156	Takifugu rubripes	61.55	0.00e+00	838.00
IUUC-Tni-119733	Tetraodon nigroviridis	61.02	0.00e+00	845.00
IUUC-Tbe-128084	Tupaia belangeri	84.83	0.00e+00	1226.00
IUUC-Ttr-128928	Tursiops truncatus	92.83	0.00e+00	1350.00
IUUC-Vpa-130706	Vicugna pacos	91.70	0.00e+00	1334.00
IUUC-Xtr-132061	Xenopus tropicalis	70.34	0.00e+00	932.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence