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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046502
UUCD1 version UUC-HoS-00262
Ensembl Protein ID ENSP00000368797.3
UniProt Accession Q8WVZ9; B5TZ86; Q5T6Y7; Q8NB99; Q9H0I6; KBTB7_HUMAN
Genbank Protein ID CAB66716.1; ACH92650.1; BAC03641.1; CAI16613.1; EAX08647.1; AAH22033.1
Protein Name Kelch repeat and BTB domain-containing protein 7
Genbank Nucleotide ID AL136782; FJ150424; AK091344; AL354696; CH471075; BC022033
Gene Name KBTBD7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120696.8 ENST00000379483.3 ENSP00000368797.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVar
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 23661552
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 7.60e-19 69.5 63 138
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.10e-10 39.2 170 201
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvv.......g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+++v       g g+ f++ + vLaa++++F+++f++++ es+ +  v+++dv++e+f++l++++Ytg+++++e
   Q: 63   CDVTIEVvtpgsgpGtGRLFSCNRNVLAAACPYFKSMFTGGMYESQ-QASVTMHDVDAESFEVLVDYCYTGRVSLSE 138
           8999999999998867*****************************9.**************************9876 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l Nc++il fAd++d ++L+++a+++i ++Fk
   Q: 170  LTNCTAILKFADAFDHHKLRSQAQSYIAHNFK 201
           58*****************************7 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR 60
LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046502|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTCTCCCG GGCGCCTAGC GGGATCGCCA GCGCGGCAGT GGGGGCTTCC GCGGCTGCAA 60
GCCAGCGGGT CCTGTGAGGG CGAGCGGAGG CGGAGAAAGG GCGCGGGAGT GAGAGAGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046502|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0000165--P:MAPK cascade
GO:0016567--P:protein ubiquitination
KEGG hsa:84078
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002412 Ailuropoda melanoleuca 95.58 0.00e+00 1253.00
IUUC-Ame-010652 Astyanax mexicanus 50.00 0.00e+00 657.00
IUUC-Bta-013332 Bos taurus 95.47 0.00e+00 1244.00
IUUC-Cja-019774 Callithrix jacchus 97.51 0.00e+00 1276.00
IUUC-Cfa-021128 Canis familiaris 94.01 0.00e+00 1233.00
IUUC-Cpo-021647 Cavia porcellus 92.11 0.00e+00 1264.00
IUUC-Csa-024241 Chlorocebus sabaeus 98.10 0.00e+00 1268.00
IUUC-Dre-028122 Danio rerio 50.16 0.00e+00 635.00
IUUC-Dno-029373 Dasypus novemcinctus 93.86 0.00e+00 1237.00
IUUC-Dor-030153 Dipodomys ordii 83.49 0.00e+00 845.00
IUUC-Eca-034128 Equus caballus 95.91 0.00e+00 1274.00
IUUC-Fca-036082 Felis catus 95.32 0.00e+00 1253.00
IUUC-Gmo-039541 Gadus morhua 46.94 1.00e-168 587.00
IUUC-Gac-042257 Gasterosteus aculeatus 48.23 3.00e-170 592.00
IUUC-Ggo-045173 Gorilla gorilla 98.54 0.00e+00 1306.00
IUUC-Itr-048955 Ictidomys tridecemlineatus 95.91 0.00e+00 1262.00
IUUC-Lch-050676 Latimeria chalumnae 62.03 0.00e+00 821.00
IUUC-Loc-052358 Lepisosteus oculatus 55.92 0.00e+00 759.00
IUUC-Laf-054091 Loxodonta africana 95.74 0.00e+00 1269.00
IUUC-Mcc-055345 Macaca mulatta 98.54 0.00e+00 1278.00
IUUC-Meu-056183 Macropus eugenii 76.82 0.00e+00 794.00
IUUC-Mmr-061693 Microcebus murinus 97.37 0.00e+00 1278.00
IUUC-Mdo-062879 Monodelphis domestica 76.05 0.00e+00 984.00
IUUC-Mmu-063250 Mus musculus 93.62 0.00e+00 1233.00
IUUC-Mlu-068069 Myotis lucifugus 93.27 0.00e+00 1244.00
IUUC-Nle-070164 Nomascus leucogenys 99.42 0.00e+00 1283.00
IUUC-Ont-071957 Oreochromis niloticus 46.42 2.00e-164 572.00
IUUC-Oan-073515 Ornithorhynchus anatinus 68.75 0.00e+00 878.00
IUUC-Ocu-074774 Oryctolagus cuniculus 85.90 0.00e+00 1134.00
IUUC-Ola-086695 Oryzias latipes 46.78 1.00e-157 550.00
IUUC-Oga-088566 Otolemur garnettii 95.20 0.00e+00 1253.00
IUUC-Oar-090137 Ovis aries 95.61 0.00e+00 1256.00
IUUC-Ptr-090662 Pan troglodytes 100.00 0.00e+00 1290.00
IUUC-Pan-092452 Papio anubis 97.95 0.00e+00 1298.00
IUUC-Pfo-097430 Poecilia formosa 46.03 2.00e-165 575.00
IUUC-Pab-097925 Pongo abelii 99.71 0.00e+00 1286.00
IUUC-Pca-100592 Procavia capensis 89.47 0.00e+00 1170.00
IUUC-Pyt-104491 Pyrenophora triticirepentis 32.08 1.00e-05 43.90
IUUC-Rno-106015 Rattus norvegicus 80.12 0.00e+00 737.00
IUUC-Sha-107610 Sarcophilus harrisii 69.34 0.00e+00 938.00
IUUC-Ssc-115906 Sus scrofa 95.17 0.00e+00 1223.00
IUUC-Tru-118563 Takifugu rubripes 45.93 2.00e-153 535.00
IUUC-Tni-120867 Tetraodon nigroviridis 45.11 1.00e-132 466.00
IUUC-Tbe-127591 Tupaia belangeri 91.23 0.00e+00 1140.00
IUUC-Ttr-128977 Tursiops truncatus 96.20 0.00e+00 1275.00
IUUC-Vpa-130491 Vicugna pacos 95.91 0.00e+00 1268.00
IUUC-Xtr-132498 Xenopus tropicalis 65.71 0.00e+00 863.00
IUUC-Xma-133681 Xiphophorus maculatus 47.10 2.00e-169 589.00
Created Date 25-Jun-2017

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