iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/RAWUL	RAWUL	9566890; 18588675

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.12	13.0	263	301
ULD/UDP/UFD/RAWUL	4.30e-23	81.7	371	465

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C +C+  + + + ++ C H f+++Cl +++       +ke  CP C
   Q: 263  CHLCQGYLINATTIVECLHSFCHSCLiNHL-------RKERFCPRC 301
           99******999999***********95655.......66666**99 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk......lkkkylrcsarltVkhlkkflaeklkl.sssyevdllce..devLednetLeeikyifiwkkegpLvLqYr 86
           +slsLe++e  + k+ds+      l+ +yl+c+a+++V+hlkkf+++k+++  +++++d++++  + vL d++tL++i+yi++wk+++p+ ++Yr
   Q: 371  MSLSLEYAELGELKTDSEpelvdtLRPRYLQCPAMCRVSHLKKFVYDKFEIdAQRFSIDIMYKvkTIVLLDYYTLMDIAYIYTWKRDAPMRFYYR 465
           79*************************************************77889******988999**************************9 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.

Protein Sequence
(Fasta)

MMTPESKAIQ PAAATTKQTA EATATTTMAH TQQKSQLSTL AKTTTTTATN KAAKSVVSNA 60
NSSGNNSSKK LALSQSQKTT TTTTPPTTTT TTTAAAAAEA TTNADKMQKQ QQLKQQLFAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTAGTGC AACACCAACA TTCAACGAGA GCGGTTCGTC GACGCTGTGC GGAAAGATTA 60
CAGAGCGAAC GAGAGAGACC GAGCCAGAGC GACGACGCCC CGCAACGAGA ACAACAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

Gene Ontology

GO:0005725--C:intercalary heterochromatin
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0005704--C:polytene chromosome band
GO:0035102--C:PRC1 complex
GO:0001047--F:core promoter binding
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0006338--P:chromatin remodeling
GO:0006342--P:chromatin silencing
GO:0035186--P:syncytial blastoderm mitotic cell cycle
GO:0007419--P:ventral cord development

KEGG

dme:Dmel_CG3886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001498	Ailuropoda melanoleuca	44.74	1.00e-52	199.00
IUUC-Apl-004208	Anas platyrhynchos	41.67	8.00e-37	146.00
IUUC-Aca-004661	Anolis carolinensis	44.44	5.00e-49	187.00
IUUC-Afl-008661	Aspergillus flavus	29.41	5.00e-07	49.70
IUUC-Ang-009542	Aspergillus niger	29.41	2.00e-06	47.40
IUUC-Aor-010000	Aspergillus oryzae	28.24	2.00e-06	47.80
IUUC-Ame-010610	Astyanax mexicanus	44.93	2.00e-53	201.00
IUUC-Bta-012606	Bos taurus	44.74	5.00e-50	190.00
IUUC-Bdi-015045	Brachypodium distachyon	44.44	1.00e-12	67.00
IUUC-Cja-019482	Callithrix jacchus	45.02	8.00e-54	202.00
IUUC-Cfa-020482	Canis familiaris	44.74	1.00e-52	199.00
IUUC-Cpo-022061	Cavia porcellus	45.45	3.00e-54	204.00
IUUC-Cre-022788	Chlamydomonas reinhardtii	32.99	1.00e-07	50.10
IUUC-Csa-024102	Chlorocebus sabaeus	44.68	1.00e-53	202.00
IUUC-Cho-025081	Choloepus hoffmanni	34.68	1.00e-35	142.00
IUUC-Dre-027953	Danio rerio	40.87	2.00e-49	188.00
IUUC-Dno-029797	Dasypus novemcinctus	45.02	5.00e-54	203.00
IUUC-Dor-030256	Dipodomys ordii	44.25	7.00e-52	196.00
IUUC-Eca-033318	Equus caballus	45.02	5.00e-53	200.00
IUUC-Eeu-034547	Erinaceus europaeus	37.40	8.00e-40	156.00
IUUC-Fca-035866	Felis catus	44.74	2.00e-52	198.00
IUUC-Fal-036660	Ficedula albicollis	44.30	8.00e-52	196.00
IUUC-Fox-037824	Fusarium oxysporum	32.26	3.00e-04	39.30
IUUC-Gmo-039341	Gadus morhua	43.42	9.00e-51	192.00
IUUC-Gga-040611	Gallus gallus	44.30	4.00e-52	197.00
IUUC-Gac-041888	Gasterosteus aculeatus	43.17	2.00e-53	201.00
IUUC-Ggo-045027	Gorilla gorilla	45.02	8.00e-54	203.00
IUUC-Hsa-045665	Homo sapiens	44.68	2.00e-53	202.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	45.13	5.00e-54	203.00
IUUC-Lch-049714	Latimeria chalumnae	42.06	2.00e-54	205.00
IUUC-Loc-052161	Lepisosteus oculatus	44.08	1.00e-52	198.00
IUUC-Laf-054108	Loxodonta africana	43.83	3.00e-53	201.00
IUUC-Mcc-055562	Macaca mulatta	44.68	2.00e-53	202.00
IUUC-Meu-056709	Macropus eugenii	45.02	2.00e-53	201.00
IUUC-Mga-060104	Meleagris gallopavo	44.10	9.00e-30	122.00
IUUC-Mmr-061191	Microcebus murinus	44.68	2.00e-53	202.00
IUUC-Mdo-062711	Monodelphis domestica	41.32	4.00e-51	194.00
IUUC-Mmu-064255	Mus musculus	45.13	1.00e-52	199.00
IUUC-Mpu-066466	Mustela putorius furo	44.74	6.00e-53	200.00
IUUC-Mlu-067622	Myotis lucifugus	44.59	2.00e-53	201.00
IUUC-Nle-069253	Nomascus leucogenys	44.68	1.00e-53	202.00
IUUC-Opr-070511	Ochotona princeps	45.02	9.00e-54	202.00
IUUC-Ont-072177	Oreochromis niloticus	44.69	8.00e-54	203.00
IUUC-Oan-073336	Ornithorhynchus anatinus	44.74	1.00e-53	202.00
IUUC-Ocu-074113	Oryctolagus cuniculus	44.74	5.00e-52	197.00
IUUC-Ola-087057	Oryzias latipes	43.81	3.00e-52	198.00
IUUC-Oga-088346	Otolemur garnettii	45.02	8.00e-54	203.00
IUUC-Oar-089843	Ovis aries	44.74	5.00e-50	190.00
IUUC-Ptr-090486	Pan troglodytes	45.02	8.00e-54	203.00
IUUC-Pan-092667	Papio anubis	44.40	4.00e-53	201.00
IUUC-Psi-093469	Pelodiscus sinensis	44.59	1.00e-53	202.00
IUUC-Pma-094481	Petromyzon marinus	42.58	6.00e-42	162.00
IUUC-Pfo-097156	Poecilia formosa	43.16	3.00e-52	197.00
IUUC-Pab-097670	Pongo abelii	45.02	8.00e-54	203.00
IUUC-Pca-100551	Procavia capensis	42.06	6.00e-47	180.00
IUUC-Pva-102800	Pteropus vampyrus	45.02	8.00e-54	203.00
IUUC-Rno-105128	Rattus norvegicus	44.25	1.00e-52	199.00
IUUC-Sha-106747	Sarcophilus harrisii	44.74	6.00e-49	187.00
IUUC-Sar-113416	Sorex araneus	45.02	7.00e-54	203.00
IUUC-Sbi-114041	Sorghum bicolor	32.22	5.00e-11	59.70
IUUC-Ssc-115864	Sus scrofa	45.02	8.00e-54	202.00
IUUC-Tgu-116851	Taeniopygia guttata	41.97	1.00e-36	145.00
IUUC-Tru-117698	Takifugu rubripes	43.53	1.00e-51	196.00
IUUC-Tsy-119590	Tarsius syrichta	45.02	7.00e-54	203.00
IUUC-Tni-120170	Tetraodon nigroviridis	44.00	6.00e-52	196.00
IUUC-Tbe-127790	Tupaia belangeri	45.02	7.00e-54	203.00
IUUC-Ttr-129316	Tursiops truncatus	45.02	2.00e-53	201.00
IUUC-Vpa-130669	Vicugna pacos	44.74	5.00e-50	190.00
IUUC-Xtr-131912	Xenopus tropicalis	43.42	6.00e-48	183.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence