iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021397

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02023953

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013415.3	ENSCPOT00000013546.2	ENSCPOP00000012077.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.10e-15	55.4	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP+ L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSILQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MDKVGKMWNT FKYRCQNLFS HEGGSHSENV DMSSNRCLSI KEKNISLGDS APQQQNSSLR 60
ENVALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDSDS CVTPGTRLTR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAAG TGGGGAAAAT GTGGAATACC TTCAAATACA GATGTCAAAA TCTTTTCAGT 60
CACGAGGGAG GAAGCCATAG TGAAAATGTG GACATGAGCT CCAACAGATG TTTGTCTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.20e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	89.55	0.00e+00	994.00
IUUC-Aca-004504	Anolis carolinensis	83.58	0.00e+00	867.00
IUUC-Ame-010677	Astyanax mexicanus	62.06	0.00e+00	639.00
IUUC-Bta-012338	Bos taurus	96.27	0.00e+00	1031.00
IUUC-Cja-019828	Callithrix jacchus	95.52	0.00e+00	1007.00
IUUC-Cfa-020369	Canis familiaris	94.96	0.00e+00	1026.00
IUUC-Csa-023856	Chlorocebus sabaeus	95.71	0.00e+00	1030.00
IUUC-Dre-028262	Danio rerio	62.99	3.00e-172	598.00
IUUC-Dno-029019	Dasypus novemcinctus	95.90	0.00e+00	1057.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	1.00e-69	257.00
IUUC-Eca-033867	Equus caballus	93.84	0.00e+00	1035.00
IUUC-Fca-035806	Felis catus	95.34	0.00e+00	1026.00
IUUC-Fal-037117	Ficedula albicollis	89.74	0.00e+00	984.00
IUUC-Gmo-039066	Gadus morhua	84.83	1.00e-108	387.00
IUUC-Gga-040876	Gallus gallus	88.99	0.00e+00	971.00
IUUC-Gac-042149	Gasterosteus aculeatus	66.85	0.00e+00	646.00
IUUC-Ggo-045169	Gorilla gorilla	94.59	0.00e+00	1023.00
IUUC-Hsa-045805	Homo sapiens	95.71	0.00e+00	1031.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.30e-02	33.10
IUUC-Itr-049048	Ictidomys tridecemlineatus	94.96	0.00e+00	1046.00
IUUC-Lch-049686	Latimeria chalumnae	78.85	0.00e+00	838.00
IUUC-Lpe-051639	Leersia perrieri	29.23	7.80e-01	28.90
IUUC-Loc-051745	Lepisosteus oculatus	72.26	0.00e+00	716.00
IUUC-Lma-053042	Leptosphaeria maculans	26.05	4.20e-01	32.30
IUUC-Laf-054124	Loxodonta africana	93.30	0.00e+00	1015.00
IUUC-Mcc-055175	Macaca mulatta	95.71	0.00e+00	1030.00
IUUC-Meu-056557	Macropus eugenii	90.91	0.00e+00	1011.00
IUUC-Mga-059214	Meleagris gallopavo	88.62	0.00e+00	984.00
IUUC-Mmr-060613	Microcebus murinus	80.04	0.00e+00	797.00
IUUC-Mdo-062788	Monodelphis domestica	90.54	0.00e+00	974.00
IUUC-Mmu-064333	Mus musculus	92.91	0.00e+00	1003.00
IUUC-Mpu-066048	Mustela putorius furo	96.46	0.00e+00	1035.00
IUUC-Mlu-067430	Myotis lucifugus	95.15	0.00e+00	999.00
IUUC-Nle-069086	Nomascus leucogenys	95.71	0.00e+00	1055.00
IUUC-Opr-070312	Ochotona princeps	91.42	0.00e+00	984.00
IUUC-Ont-072299	Oreochromis niloticus	64.12	0.00e+00	641.00
IUUC-Ocu-074123	Oryctolagus cuniculus	90.11	0.00e+00	966.00
IUUC-Ola-086934	Oryzias latipes	66.36	0.00e+00	652.00
IUUC-Oga-088535	Otolemur garnettii	95.52	0.00e+00	1051.00
IUUC-Oar-089875	Ovis aries	95.71	0.00e+00	1030.00
IUUC-Ptr-090541	Pan troglodytes	95.71	0.00e+00	1031.00
IUUC-Pan-092416	Papio anubis	95.71	0.00e+00	1030.00
IUUC-Psi-092960	Pelodiscus sinensis	87.50	0.00e+00	974.00
IUUC-Pma-094222	Petromyzon marinus	50.36	8.00e-137	480.00
IUUC-Pfo-096930	Poecilia formosa	64.54	0.00e+00	659.00
IUUC-Pab-098659	Pongo abelii	95.71	0.00e+00	1031.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.50e-01	30.80
IUUC-Pca-100222	Procavia capensis	91.62	0.00e+00	1007.00
IUUC-Pva-102387	Pteropus vampyrus	95.34	0.00e+00	1025.00
IUUC-Rno-105698	Rattus norvegicus	93.10	0.00e+00	1009.00
IUUC-Sha-107234	Sarcophilus harrisii	89.05	0.00e+00	969.00
IUUC-Sar-113698	Sorex araneus	87.13	0.00e+00	895.00
IUUC-Ssc-115985	Sus scrofa	95.15	0.00e+00	1048.00
IUUC-Tgu-116676	Taeniopygia guttata	89.55	0.00e+00	987.00
IUUC-Tru-118441	Takifugu rubripes	58.56	5.00e-150	524.00
IUUC-Tsy-119163	Tarsius syrichta	88.25	0.00e+00	972.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.30	0.00e+00	645.00
IUUC-Tca-121188	Theobroma cacao	32.81	4.10e-01	29.30
IUUC-Tae-124846	Triticum aestivum	36.73	2.40e-02	32.00
IUUC-Tbe-127353	Tupaia belangeri	95.71	0.00e+00	1026.00
IUUC-Ttr-128907	Tursiops truncatus	95.52	0.00e+00	1007.00
IUUC-Vpa-130140	Vicugna pacos	95.34	0.00e+00	1030.00
IUUC-Xtr-132817	Xenopus tropicalis	79.52	0.00e+00	869.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence