iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045487

Ensembl Protein ID

ENSGGOP00000025725.1

UniProt Accession

G3SC98; G3SC98_GORGO

Protein Name

Uncharacterized protein

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000025524.1	ENSGGOT00000025832.1	ENSGGOP00000025725.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-46	156.1	193	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ ++
   Q: 193  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTVMQ 252
           689**************************************.59*************9765 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

KMAEEVVVVA KFDYVAQQEQ ELDIKKNERL WLLDDSKSWW RVRNSMNKTG FVPSNYVERK 60
NSARKASIVK NLKDTLGIGK VKRKPSVPDS ASPADDSFVD PGERLYDLNM PAYVKFNYMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAGAGCTA CGCGGCGGCG GCGGAGCGCA GGCCTCGTGC CTTTACGGCC ATCACGGCGG 60
CCGCGGTGGC GTCCTGGAGC CCTCCTCAGG TGAGCTGGAG CTGCCCGGCT CGGCAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.94	0.00e+00	739.00
IUUC-Ame-011235	Astyanax mexicanus	78.36	2.00e-180	624.00
IUUC-Bta-013039	Bos taurus	98.94	0.00e+00	738.00
IUUC-Cja-019546	Callithrix jacchus	98.67	0.00e+00	731.00
IUUC-Cfa-020462	Canis familiaris	99.20	0.00e+00	740.00
IUUC-Cpo-022009	Cavia porcellus	98.41	0.00e+00	734.00
IUUC-Csa-023875	Chlorocebus sabaeus	100.00	0.00e+00	741.00
IUUC-Cho-024368	Choloepus hoffmanni	97.38	0.00e+00	651.00
IUUC-Csv-026046	Ciona savignyi	40.85	5.00e-72	264.00
IUUC-Dre-028407	Danio rerio	77.31	8.00e-178	615.00
IUUC-Dno-029593	Dasypus novemcinctus	99.04	4.00e-175	606.00
IUUC-Dor-030730	Dipodomys ordii	98.40	0.00e+00	644.00
IUUC-Dme-031846	Drosophila melanogaster	43.35	5.00e-92	331.00
IUUC-Ete-032906	Echinops telfairi	98.14	0.00e+00	728.00
IUUC-Eca-033378	Equus caballus	98.78	0.00e+00	639.00
IUUC-Eeu-034743	Erinaceus europaeus	88.33	0.00e+00	676.00
IUUC-Fca-035745	Felis catus	98.94	0.00e+00	780.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.90	1.00e-159	555.00
IUUC-Hsa-045902	Homo sapiens	100.00	0.00e+00	741.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	99.20	0.00e+00	739.00
IUUC-Lch-050165	Latimeria chalumnae	83.02	0.00e+00	627.00
IUUC-Loc-052523	Lepisosteus oculatus	78.95	7.00e-180	622.00
IUUC-Laf-053845	Loxodonta africana	98.94	0.00e+00	737.00
IUUC-Meu-056139	Macropus eugenii	92.04	0.00e+00	668.00
IUUC-Mmr-061108	Microcebus murinus	87.53	1.00e-174	605.00
IUUC-Mdo-062258	Monodelphis domestica	94.96	0.00e+00	713.00
IUUC-Mmu-063970	Mus musculus	98.94	0.00e+00	780.00
IUUC-Mpu-066093	Mustela putorius furo	98.68	0.00e+00	738.00
IUUC-Mlu-067193	Myotis lucifugus	98.94	0.00e+00	738.00
IUUC-Nle-069611	Nomascus leucogenys	100.00	0.00e+00	741.00
IUUC-Opr-070984	Ochotona princeps	97.67	2.00e-179	621.00
IUUC-Ont-072241	Oreochromis niloticus	75.90	1.00e-171	595.00
IUUC-Oan-072976	Ornithorhynchus anatinus	90.23	1.00e-167	582.00
IUUC-Ocu-073905	Oryctolagus cuniculus	99.47	0.00e+00	740.00
IUUC-Ola-086513	Oryzias latipes	74.94	1.00e-159	555.00
IUUC-Oga-088588	Otolemur garnettii	99.47	0.00e+00	739.00
IUUC-Oar-089973	Ovis aries	99.20	0.00e+00	740.00
IUUC-Ptr-090968	Pan troglodytes	100.00	0.00e+00	741.00
IUUC-Pan-092840	Papio anubis	100.00	4.00e-176	610.00
IUUC-Pfo-096057	Poecilia formosa	74.23	6.00e-169	586.00
IUUC-Pab-097807	Pongo abelii	99.73	0.00e+00	741.00
IUUC-Pca-100522	Procavia capensis	98.40	8.00e-174	602.00
IUUC-Pva-103083	Pteropus vampyrus	99.20	0.00e+00	739.00
IUUC-Rno-104839	Rattus norvegicus	96.55	0.00e+00	743.00
IUUC-Sha-107294	Sarcophilus harrisii	94.43	0.00e+00	706.00
IUUC-Sar-113675	Sorex araneus	97.35	0.00e+00	724.00
IUUC-Ssc-116442	Sus scrofa	97.61	0.00e+00	771.00
IUUC-Tru-118058	Takifugu rubripes	74.55	2.00e-168	585.00
IUUC-Tsy-119184	Tarsius syrichta	91.94	0.00e+00	632.00
IUUC-Tni-119974	Tetraodon nigroviridis	74.74	5.00e-157	546.00
IUUC-Ttr-129155	Tursiops truncatus	96.82	0.00e+00	732.00
IUUC-Vpa-130344	Vicugna pacos	98.94	0.00e+00	739.00
IUUC-Xtr-132372	Xenopus tropicalis	87.50	0.00e+00	659.00
IUUC-Xma-133087	Xiphophorus maculatus	74.23	4.00e-169	587.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence