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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046378
Ensembl Protein ID ENSP00000365012.2
UniProt Accession J3KPD6; J3KPD6_HUMAN
Genbank Protein ID ENSP00000365012
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID AL049539
Gene Name HCK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101336.12 ENST00000375862.6 ENSP00000365022.2
ENSG00000101336.12 ENST00000486475.5 ENSP00000420457.1
ENSG00000101336.12 ENST00000262651.3 ENSP00000262651.3
ENSG00000101336.12 ENST00000375852.2 ENSP00000365012.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircRNADbCircNetmicroRNA
TRANSFACRepTarmiRcodeRAID2
Protein-protein Interaction
HINTInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.30e-15 58.8 82 137
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 82   IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 137
           689************************...99*************************97 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
LGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK 60
PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046378|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGTTAGCC TCGCTCAGGG CGCGGCTAAG GCGCCCAGAT GGCCTGCGGG CGCCACCACG 60
TCCCTGGTCC CAGCTCGGGA GCACATCAGA GGCTTAGAGG CGAGTGGGAA GGGACTCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046378|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000140 Aegilops tauschii 30.62 9.00e-22 99.40
IUUC-Aml-001284 Ailuropoda melanoleuca 90.70 0.00e+00 987.00
IUUC-Apl-003285 Anas platyrhynchos 78.45 0.00e+00 815.00
IUUC-Aca-004724 Anolis carolinensis 78.24 0.00e+00 798.00
IUUC-Ame-011954 Astyanax mexicanus 75.74 0.00e+00 773.00
IUUC-Bta-013060 Bos taurus 91.25 0.00e+00 999.00
IUUC-Bdi-014122 Brachypodium distachyon 31.40 7.00e-22 99.40
IUUC-Cja-019817 Callithrix jacchus 95.26 0.00e+00 984.00
IUUC-Cfa-020511 Canis familiaris 91.44 0.00e+00 998.00
IUUC-Cpo-022538 Cavia porcellus 90.53 0.00e+00 951.00
IUUC-Csa-024143 Chlorocebus sabaeus 98.02 0.00e+00 1031.00
IUUC-Dre-028157 Danio rerio 75.74 0.00e+00 795.00
IUUC-Dno-029761 Dasypus novemcinctus 89.31 0.00e+00 939.00
IUUC-Eca-034090 Equus caballus 88.40 0.00e+00 958.00
IUUC-Fca-035937 Felis catus 88.76 0.00e+00 939.00
IUUC-Fal-036624 Ficedula albicollis 78.24 0.00e+00 806.00
IUUC-Gmo-039009 Gadus morhua 72.48 0.00e+00 759.00
IUUC-Gga-040296 Gallus gallus 78.90 0.00e+00 785.00
IUUC-Gac-042362 Gasterosteus aculeatus 74.12 0.00e+00 786.00
IUUC-Ggo-044570 Gorilla gorilla 99.62 0.00e+00 1085.00
IUUC-Itr-048695 Ictidomys tridecemlineatus 87.64 0.00e+00 949.00
IUUC-Loc-052904 Lepisosteus oculatus 78.30 0.00e+00 825.00
IUUC-Laf-053654 Loxodonta africana 89.96 0.00e+00 939.00
IUUC-Mcc-055317 Macaca mulatta 98.02 0.00e+00 1033.00
IUUC-Mga-060194 Meleagris gallopavo 80.89 0.00e+00 769.00
IUUC-Mmr-061510 Microcebus murinus 89.50 0.00e+00 943.00
IUUC-Mdo-062035 Monodelphis domestica 83.50 0.00e+00 877.00
IUUC-Mmu-064037 Mus musculus 89.73 0.00e+00 984.00
IUUC-Mpu-066874 Mustela putorius furo 90.69 0.00e+00 954.00
IUUC-Mlu-068202 Myotis lucifugus 86.96 0.00e+00 899.00
IUUC-Nle-069222 Nomascus leucogenys 98.02 0.00e+00 1022.00
IUUC-Opr-070705 Ochotona princeps 87.64 0.00e+00 971.00
IUUC-Ont-072347 Oreochromis niloticus 82.74 0.00e+00 771.00
IUUC-Ocu-074490 Oryctolagus cuniculus 89.11 0.00e+00 928.00
IUUC-Ola-086521 Oryzias latipes 81.61 0.00e+00 781.00
IUUC-Oga-088153 Otolemur garnettii 92.09 0.00e+00 969.00
IUUC-Oar-090184 Ovis aries 90.02 0.00e+00 964.00
IUUC-Ptr-090505 Pan troglodytes 96.01 0.00e+00 1033.00
IUUC-Pan-092260 Papio anubis 98.22 0.00e+00 1036.00
IUUC-Pma-094311 Petromyzon marinus 75.73 0.00e+00 734.00
IUUC-Pfo-096566 Poecilia formosa 75.49 0.00e+00 796.00
IUUC-Pab-097908 Pongo abelii 79.28 0.00e+00 825.00
IUUC-Pva-103021 Pteropus vampyrus 90.50 0.00e+00 949.00
IUUC-Rno-105309 Rattus norvegicus 89.70 0.00e+00 940.00
IUUC-Sha-107099 Sarcophilus harrisii 83.01 0.00e+00 876.00
IUUC-Tgu-116912 Taeniopygia guttata 78.22 0.00e+00 797.00
IUUC-Tru-118449 Takifugu rubripes 81.35 0.00e+00 764.00
IUUC-Tae-123192 Triticum aestivum 31.01 3.00e-22 100.00
IUUC-Tur-126022 Triticum urartu 31.01 3.00e-22 100.00
IUUC-Tbe-128144 Tupaia belangeri 77.57 0.00e+00 823.00
IUUC-Xma-133902 Xiphophorus maculatus 75.30 0.00e+00 792.00
Created Date 25-Jun-2017

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