iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020859

Ensembl Protein ID

ENSCAFP00000001118.3

UniProt Accession

Q95N78; PPARA_CANLF

Genbank Protein ID

AAK38655.1

Protein Name

Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1

Genbank Nucleotide ID

AF350327

Gene Name

PPARA; NR1C1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000788.3	ENSCAFT00000001222.3	ENSCAFP00000001118.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	94.66	0.00e+00	924.00	IUUC-Hsa-046893

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).

Protein Sequence
(Fasta)

MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFS FTEYQYLGSG 60
PGSDGSVITD TLSPAPSPSS VTHPAAPGGA EEPSSVALNI ECRICGDRAS GYHYGVHACE 120

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Nucleotide Sequence
(Fasta)

GGTTTCCCAT TACCGCTCAA GTAGGGTCAC CGTGACTTTC CTCTTCCAAG GTGGTGGAGA 60
GTTGGGGAGA ATCCAGAGGC CATATCGTAG CCGTTTCCTC CTTTACCTCC GAACTGCCAA 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0004872--F:receptor activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0032099--P:negative regulation of appetite
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0019217--P:regulation of fatty acid metabolic process
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0042060--P:wound healing

KEGG

cfa:403654

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002222	Ailuropoda melanoleuca	96.60	0.00e+00	944.00
IUUC-Apl-003330	Anas platyrhynchos	87.71	0.00e+00	834.00
IUUC-Aca-004598	Anolis carolinensis	84.62	0.00e+00	815.00
IUUC-Acl-008339	Aspergillus clavatus	45.45	1.80e-01	29.30
IUUC-Ame-011508	Astyanax mexicanus	74.04	0.00e+00	702.00
IUUC-Bta-012621	Bos taurus	95.30	0.00e+00	899.00
IUUC-Cja-019688	Callithrix jacchus	94.02	0.00e+00	887.00
IUUC-Cpo-021607	Cavia porcellus	87.61	0.00e+00	834.00
IUUC-Csa-023313	Chlorocebus sabaeus	94.23	0.00e+00	888.00
IUUC-Cho-024741	Choloepus hoffmanni	84.40	0.00e+00	755.00
IUUC-Cgl-026615	Colletotrichum gloeosporioides	34.48	3.80e-01	27.30
IUUC-Dre-027446	Danio rerio	72.34	0.00e+00	688.00
IUUC-Dno-029173	Dasypus novemcinctus	92.52	0.00e+00	862.00
IUUC-Dor-030581	Dipodomys ordii	89.72	0.00e+00	808.00
IUUC-Ete-032330	Echinops telfairi	91.24	0.00e+00	881.00
IUUC-Eca-033712	Equus caballus	94.66	0.00e+00	884.00
IUUC-Fca-036555	Felis catus	97.66	0.00e+00	951.00
IUUC-Fal-036677	Ficedula albicollis	87.18	0.00e+00	828.00
IUUC-Gmo-039240	Gadus morhua	81.55	0.00e+00	641.00
IUUC-Gga-040473	Gallus gallus	88.46	0.00e+00	840.00
IUUC-Gac-041872	Gasterosteus aculeatus	72.09	0.00e+00	699.00
IUUC-Ggo-045226	Gorilla gorilla	94.66	0.00e+00	893.00
IUUC-Hsa-046893	Homo sapiens	94.66	0.00e+00	893.00
IUUC-Itr-048952	Ictidomys tridecemlineatus	91.45	0.00e+00	869.00
IUUC-Lch-050116	Latimeria chalumnae	79.91	0.00e+00	766.00
IUUC-Loc-052131	Lepisosteus oculatus	83.00	0.00e+00	686.00
IUUC-Laf-054323	Loxodonta africana	94.23	0.00e+00	891.00
IUUC-Mcc-054841	Macaca mulatta	94.66	0.00e+00	888.00
IUUC-Meu-056833	Macropus eugenii	83.33	0.00e+00	755.00
IUUC-Mtr-058471	Medicago truncatula	29.82	2.20e-01	30.00
IUUC-Mga-059995	Meleagris gallopavo	79.24	0.00e+00	739.00
IUUC-Mdo-061954	Monodelphis domestica	90.58	0.00e+00	779.00
IUUC-Mmu-064295	Mus musculus	90.17	0.00e+00	825.00
IUUC-Mpu-066216	Mustela putorius furo	97.01	0.00e+00	947.00
IUUC-Nle-069970	Nomascus leucogenys	94.44	0.00e+00	889.00
IUUC-Ont-071594	Oreochromis niloticus	72.94	0.00e+00	690.00
IUUC-Oan-073501	Ornithorhynchus anatinus	90.22	0.00e+00	757.00
IUUC-Ocu-074634	Oryctolagus cuniculus	84.49	0.00e+00	830.00
IUUC-Oni-082926	Oryza nivara	29.41	8.00e-03	31.20
IUUC-Ola-086585	Oryzias latipes	79.58	0.00e+00	633.00
IUUC-Oga-088738	Otolemur garnettii	94.87	0.00e+00	885.00
IUUC-Oar-090453	Ovis aries	94.87	0.00e+00	894.00
IUUC-Ptr-091518	Pan troglodytes	94.44	0.00e+00	885.00
IUUC-Pan-092006	Papio anubis	94.44	0.00e+00	886.00
IUUC-Psi-093352	Pelodiscus sinensis	86.23	0.00e+00	834.00
IUUC-Pfo-096060	Poecilia formosa	72.73	0.00e+00	683.00
IUUC-Pab-098602	Pongo abelii	88.19	0.00e+00	791.00
IUUC-Pva-102175	Pteropus vampyrus	89.10	0.00e+00	860.00
IUUC-Rno-105283	Rattus norvegicus	91.03	0.00e+00	828.00
IUUC-Sce-106436	Saccharomyces cerevisiae	29.03	1.00e-02	31.60
IUUC-Sha-106560	Sarcophilus harrisii	91.67	0.00e+00	860.00
IUUC-Smo-109075	Selaginella moellendorffii	30.00	8.70e-02	30.00
IUUC-Ssc-115266	Sus scrofa	95.30	0.00e+00	932.00
IUUC-Tgu-116778	Taeniopygia guttata	87.18	0.00e+00	829.00
IUUC-Tru-118436	Takifugu rubripes	71.25	0.00e+00	687.00
IUUC-Tsy-119642	Tarsius syrichta	81.41	0.00e+00	742.00
IUUC-Tni-119859	Tetraodon nigroviridis	71.67	0.00e+00	685.00
IUUC-Tvi-122624	Trichoderma virens	30.91	2.90e-01	27.70
IUUC-Tbe-127464	Tupaia belangeri	93.16	0.00e+00	906.00
IUUC-Ttr-129307	Tursiops truncatus	91.68	0.00e+00	850.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence