iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	22306998

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.50e-08	34.9	71	157

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 64   rgpsaaakpkaglrseaaaapapapaptp....tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           rg s+++   +g       +p p+    p    +   + ++ ++drlp++ +v+i+++l++++l+r+arvcrrw++la +++lw+t+
   Q: 71   RGSSTSSSSITGETVAMVHSPPPTRLTHPlirlASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 157
           5555555555555555555555554444411112334567889********************************99999****997 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Protein Sequence
(Fasta)

MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT LSTPSPALIC 60
PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACTCGCTC CGGGGACCCG CAACAAGTGG CCGCCGCGCC CTCCCCGGGG AAGCCGCGGG 60
CGCGCAGGGG CAGCCGAAGG AGGCGGTCGA GCCGCGGAGC CCAGGGGCCT GCCCGGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0433--Leucine-rich repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0008283--P:cell proliferation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0010265--P:SCF complex assembly
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:23194

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002298	Ailuropoda melanoleuca	98.00	0.00e+00	887.00
IUUC-Apl-003410	Anas platyrhynchos	95.32	0.00e+00	872.00
IUUC-Aca-004422	Anolis carolinensis	91.04	0.00e+00	876.00
IUUC-Aly-006311	Arabidopsis lyrata	26.54	4.00e-27	116.00
IUUC-Ago-007947	Ashbya gossypii	26.29	9.00e-24	106.00
IUUC-Afl-008576	Aspergillus flavus	26.61	1.00e-26	115.00
IUUC-Ang-009819	Aspergillus niger	27.12	2.00e-27	117.00
IUUC-Aor-010050	Aspergillus oryzae	26.61	1.00e-26	115.00
IUUC-Ate-010306	Aspergillus terreus	25.40	3.00e-28	120.00
IUUC-Ame-010878	Astyanax mexicanus	82.30	0.00e+00	735.00
IUUC-Bgr-012097	Blumeria graminis	25.94	1.00e-26	115.00
IUUC-Bta-013145	Bos taurus	97.77	0.00e+00	889.00
IUUC-Bci-013923	Botrytis cinerea	25.91	1.00e-24	108.00
IUUC-Bra-016671	Brassica rapa	30.51	9.00e-29	122.00
IUUC-Cja-019612	Callithrix jacchus	98.89	0.00e+00	895.00
IUUC-Cfa-020920	Canis familiaris	87.28	0.00e+00	799.00
IUUC-Cpo-022293	Cavia porcellus	96.88	0.00e+00	882.00
IUUC-Csa-024100	Chlorocebus sabaeus	99.77	0.00e+00	898.00
IUUC-Dre-028464	Danio rerio	81.50	0.00e+00	759.00
IUUC-Dno-028849	Dasypus novemcinctus	97.07	0.00e+00	875.00
IUUC-Dor-030835	Dipodomys ordii	89.50	8.00e-91	327.00
IUUC-Dme-031686	Drosophila melanogaster	49.47	2.00e-108	387.00
IUUC-Eca-034259	Equus caballus	98.54	0.00e+00	930.00
IUUC-Fca-035850	Felis catus	97.97	0.00e+00	879.00
IUUC-Fal-037009	Ficedula albicollis	95.93	0.00e+00	919.00
IUUC-Fox-037823	Fusarium oxysporum	26.07	6.00e-34	139.00
IUUC-Gmo-038560	Gadus morhua	72.85	4.00e-100	357.00
IUUC-Gga-040391	Gallus gallus	94.43	0.00e+00	864.00
IUUC-Gac-041464	Gasterosteus aculeatus	71.14	0.00e+00	651.00
IUUC-Ggo-044556	Gorilla gorilla	99.78	0.00e+00	909.00
IUUC-Itr-048013	Ictidomys tridecemlineatus	98.37	0.00e+00	936.00
IUUC-Lch-050268	Latimeria chalumnae	89.53	0.00e+00	801.00
IUUC-Loc-051910	Lepisosteus oculatus	90.02	0.00e+00	856.00
IUUC-Lma-053322	Leptosphaeria maculans	24.16	8.00e-22	99.80
IUUC-Laf-053599	Loxodonta africana	97.55	0.00e+00	884.00
IUUC-Mcc-055225	Macaca mulatta	100.00	0.00e+00	951.00
IUUC-Meu-056341	Macropus eugenii	97.08	0.00e+00	917.00
IUUC-Mga-059525	Meleagris gallopavo	94.65	0.00e+00	860.00
IUUC-Mmr-060571	Microcebus murinus	98.98	0.00e+00	941.00
IUUC-Mdo-062229	Monodelphis domestica	97.55	0.00e+00	884.00
IUUC-Mmu-063408	Mus musculus	98.37	0.00e+00	954.00
IUUC-Mpu-065742	Mustela putorius furo	98.17	0.00e+00	935.00
IUUC-Mlu-067442	Myotis lucifugus	96.13	0.00e+00	896.00
IUUC-Nle-069404	Nomascus leucogenys	99.79	0.00e+00	937.00
IUUC-Opr-070457	Ochotona princeps	97.70	0.00e+00	919.00
IUUC-Ont-072288	Oreochromis niloticus	70.88	0.00e+00	677.00
IUUC-Oan-073492	Ornithorhynchus anatinus	95.50	0.00e+00	862.00
IUUC-Ocu-074513	Oryctolagus cuniculus	97.30	0.00e+00	874.00
IUUC-Ola-086573	Oryzias latipes	70.88	0.00e+00	648.00
IUUC-Oga-088674	Otolemur garnettii	97.71	0.00e+00	922.00
IUUC-Oar-090268	Ovis aries	91.98	0.00e+00	837.00
IUUC-Ptr-091375	Pan troglodytes	100.00	0.00e+00	951.00
IUUC-Pan-091683	Papio anubis	100.00	0.00e+00	909.00
IUUC-Psi-093199	Pelodiscus sinensis	95.55	0.00e+00	872.00
IUUC-Pma-094494	Petromyzon marinus	54.07	5.00e-112	397.00
IUUC-Pno-094936	Phaeosphaeria nodorum	25.45	5.00e-22	100.00
IUUC-Pfo-097004	Poecilia formosa	70.00	0.00e+00	673.00
IUUC-Pab-098590	Pongo abelii	99.77	0.00e+00	898.00
IUUC-Pca-100228	Procavia capensis	84.60	0.00e+00	754.00
IUUC-Pva-103166	Pteropus vampyrus	98.12	0.00e+00	918.00
IUUC-Pte-104075	Pyrenophora teres	24.74	3.00e-19	90.90
IUUC-Rno-104887	Rattus norvegicus	98.65	0.00e+00	882.00
IUUC-Sha-107379	Sarcophilus harrisii	97.10	0.00e+00	882.00
IUUC-Ssl-108575	Sclerotinia sclerotiorum	26.95	2.00e-15	78.20
IUUC-Sly-111591	Solanum lycopersicum	34.04	3.00e-30	127.00
IUUC-Stu-112488	Solanum tuberosum	33.46	2.00e-29	124.00
IUUC-Sar-113379	Sorex araneus	96.24	0.00e+00	909.00
IUUC-Ssc-115408	Sus scrofa	98.22	0.00e+00	892.00
IUUC-Tgu-117432	Taeniopygia guttata	94.99	0.00e+00	899.00
IUUC-Tru-117799	Takifugu rubripes	70.28	0.00e+00	674.00
IUUC-Tsy-119149	Tarsius syrichta	71.43	7.00e-55	207.00
IUUC-Tni-120688	Tetraodon nigroviridis	71.29	0.00e+00	670.00
IUUC-Tbe-127372	Tupaia belangeri	98.33	0.00e+00	921.00
IUUC-Ttr-128176	Tursiops truncatus	97.29	0.00e+00	917.00
IUUC-Vpa-130343	Vicugna pacos	98.77	7.00e-141	493.00
IUUC-Xtr-132187	Xenopus tropicalis	92.90	0.00e+00	856.00
IUUC-Xma-134176	Xiphophorus maculatus	70.00	0.00e+00	671.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence