iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012880

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DAAA02026216

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018528.3	ENSBTAT00000037865.2	ENSBTAP00000037687.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-85	287.8	191	815

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp.............kepkgellkslqklfeelwkskkkavsprell 74
           +G++NlgNtC++N+v+Q L++   l+el++e  ++  kl+                  ++ g+l+++l  +++++ +++++  sp+ l+
   Q: 191  KGITNLGNTCFFNAVMQNLAQSYILTELMNEikEHGTKLKI--VpssdsqldplvveLSSPGPLTSALFLFLHSMKETERGPLSPKVLF 277
           59**************************9995533333333..2335556666666677777*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksqikcl 157
           ++l+++a+ f++++qqD+qE+l++lld++++e +k+ +  + +++++ ++++ d++ +kk k +       ++i+++F g+l+s+++c+
   Q: 278  NQLCQKAPAFKSFQQQDSQELLHYLLDAVRTEETKRIQAGILKAFNNPTTKTADDETRKKVKAYGregvkmNFIDRIFIGELTSTVMCE 366
           *********************************99788887777777777777774444444443455555****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec n+s+ ++pf+d+slp+ +++ +k+                                                              
   Q: 367  ECSNISTVKDPFIDISLPIIEERVSKPVllgriskygrlqetdngqysgtvpventhqprairkhslskdmnqlihgrkctrksssged 455
           ***********************98777************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  kaaviyqeneslevnrdsslfasimnteltltesptdgsekedslsessvdadseasesesapkqtlllrsrsgyythtnghphypsks 544
           ***************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftke 197
                                                                                        s+q+cL +ft+ 
   Q: 545  epltregdhgdegvaeaiselhlsstiirardfdrenqplsvsnnlcfsedkhmvsqspqnafqtlsqsyittskecSVQSCLYQFTSM 633
           ***************************************************************************************** PP
   S: 198  eelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ 
   Q: 634  ELLMGNNKLLCENCTEKKQkyqkettsaekkaegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLTLDLAPFCSA 720
           ***************99999999999999999999999*********************..9999************************ PP
   S: 268  peekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgs 328
           +++++++  k+ Y L++vv HsGs+++GHY+ayvk                           +  +W++++D++V++v+e++ l+   +
   Q: 721  TCKNVSVggKVLYGLYGVVEHSGSMKGGHYTAYVKVrtpsrklleyitgkknvpglkepdseSASQWVHVSDTYVQVVPESRALS---A 806
           9999887889**************************999999999999999999999888766777*******************...* PP
   S: 329  taYvlfYkr 337
           +aY+lfY+r
   Q: 807  QAYLLFYER 815
           *******98 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MRVKEPSKAS PEKAKRSKRP PIPHDEDSSD DVAVGFTCQH ISHAVSVHHV KKAIAENLWS 60
VCLECVKERR FCDGQPVLLP DIWLCLKCGF QGCGKNSEGQ HSLKHFKSWR AELHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AAGAGCCATC CAAAGCTTCA CCTGAGAAAG CTAAGAGAAG TAAAAGGCCT 60
CCTATACCTC ACGATGAAGA CTCGTCAGAT GACGTTGCTG GTAAGTTATG ATGTCTCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:540972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	75.52	0.00e+00	1152.00
IUUC-Apl-003512	Anas platyrhynchos	68.98	0.00e+00	1091.00
IUUC-Aca-004284	Anolis carolinensis	62.79	0.00e+00	979.00
IUUC-Ame-010735	Astyanax mexicanus	48.87	1.00e-107	383.00
IUUC-Cja-019144	Callithrix jacchus	81.30	0.00e+00	1338.00
IUUC-Cfa-020971	Canis familiaris	82.96	0.00e+00	747.00
IUUC-Cpo-022497	Cavia porcellus	79.25	0.00e+00	721.00
IUUC-Csa-023910	Chlorocebus sabaeus	80.80	0.00e+00	1229.00
IUUC-Cho-024358	Choloepus hoffmanni	62.79	7.00e-115	407.00
IUUC-Dre-028106	Danio rerio	53.16	0.00e+00	806.00
IUUC-Dno-029456	Dasypus novemcinctus	75.00	0.00e+00	709.00
IUUC-Dor-030438	Dipodomys ordii	64.63	0.00e+00	969.00
IUUC-Dme-031870	Drosophila melanogaster	47.90	2.00e-36	147.00
IUUC-Ete-032736	Echinops telfairi	65.74	0.00e+00	979.00
IUUC-Eca-034211	Equus caballus	86.31	0.00e+00	1413.00
IUUC-Eeu-034797	Erinaceus europaeus	78.57	4.00e-87	315.00
IUUC-Fca-035947	Felis catus	81.17	0.00e+00	1218.00
IUUC-Fal-037199	Ficedula albicollis	68.35	0.00e+00	950.00
IUUC-Gmo-039228	Gadus morhua	60.00	6.00e-139	488.00
IUUC-Gga-040823	Gallus gallus	65.94	3.00e-175	608.00
IUUC-Gac-042406	Gasterosteus aculeatus	52.83	0.00e+00	777.00
IUUC-Ggo-045402	Gorilla gorilla	81.71	0.00e+00	1323.00
IUUC-Hsa-046430	Homo sapiens	81.56	0.00e+00	1326.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	82.05	0.00e+00	770.00
IUUC-Lch-049547	Latimeria chalumnae	58.42	0.00e+00	915.00
IUUC-Loc-052842	Lepisosteus oculatus	58.24	0.00e+00	904.00
IUUC-Laf-053988	Loxodonta africana	81.95	0.00e+00	1325.00
IUUC-Mcc-055491	Macaca mulatta	77.90	0.00e+00	1248.00
IUUC-Meu-056256	Macropus eugenii	65.25	0.00e+00	637.00
IUUC-Mla-059026	Melampsora laricipopulina	31.71	1.00e-17	84.70
IUUC-Mga-059833	Meleagris gallopavo	62.43	5.00e-177	613.00
IUUC-Mmr-060952	Microcebus murinus	80.44	0.00e+00	1278.00
IUUC-Mdo-062642	Monodelphis domestica	70.62	0.00e+00	1099.00
IUUC-Mmu-063945	Mus musculus	77.87	0.00e+00	1243.00
IUUC-Mac-064941	Musa acuminata	29.08	6.00e-49	189.00
IUUC-Mpu-065944	Mustela putorius furo	79.19	0.00e+00	1228.00
IUUC-Mlu-067049	Myotis lucifugus	84.62	0.00e+00	1337.00
IUUC-Nle-069828	Nomascus leucogenys	81.56	0.00e+00	1316.00
IUUC-Opr-070672	Ochotona princeps	67.84	1.00e-136	480.00
IUUC-Ont-072121	Oreochromis niloticus	59.26	1.00e-136	480.00
IUUC-Oan-073656	Ornithorhynchus anatinus	65.62	0.00e+00	1050.00
IUUC-Ocu-074323	Oryctolagus cuniculus	78.36	0.00e+00	1232.00
IUUC-Ola-087238	Oryzias latipes	52.32	0.00e+00	798.00
IUUC-Oga-088379	Otolemur garnettii	75.30	0.00e+00	1209.00
IUUC-Oar-089718	Ovis aries	97.31	0.00e+00	1547.00
IUUC-Ptr-091358	Pan troglodytes	81.81	0.00e+00	1330.00
IUUC-Pan-092023	Papio anubis	81.81	0.00e+00	1323.00
IUUC-Psi-093256	Pelodiscus sinensis	67.23	0.00e+00	1009.00
IUUC-Pfo-097285	Poecilia formosa	48.97	0.00e+00	711.00
IUUC-Pab-098539	Pongo abelii	81.54	0.00e+00	1322.00
IUUC-Pca-100610	Procavia capensis	67.53	0.00e+00	924.00
IUUC-Pva-102985	Pteropus vampyrus	91.89	0.00e+00	709.00
IUUC-Rno-105538	Rattus norvegicus	77.14	0.00e+00	1240.00
IUUC-Sha-107022	Sarcophilus harrisii	62.46	0.00e+00	979.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.07	1.00e-20	94.70
IUUC-Spo-108149	Schizosaccharomyces pombe	30.39	2.00e-21	97.40
IUUC-Sar-113637	Sorex araneus	73.11	0.00e+00	1092.00
IUUC-Ssc-115870	Sus scrofa	88.13	0.00e+00	1458.00
IUUC-Tgu-116907	Taeniopygia guttata	67.80	0.00e+00	1075.00
IUUC-Tru-117835	Takifugu rubripes	52.25	5.00e-108	385.00
IUUC-Tsy-118869	Tarsius syrichta	80.88	0.00e+00	1140.00
IUUC-Tni-119716	Tetraodon nigroviridis	63.86	1.00e-94	340.00
IUUC-Tbe-128041	Tupaia belangeri	69.97	0.00e+00	924.00
IUUC-Ttr-128901	Tursiops truncatus	87.15	0.00e+00	1408.00
IUUC-Vpa-130331	Vicugna pacos	88.08	0.00e+00	1318.00
IUUC-Xtr-131794	Xenopus tropicalis	52.42	0.00e+00	780.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence