iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062570

UUCD1 version

UUC-MoD-00375

Ensembl Protein ID

ENSMODP00000021625.3

UniProt Accession

F6WWH0; F6WWH0_MONDO

Protein Name

Uncharacterized protein

Gene Name

TRAF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017325.3	ENSMODT00000022001.3	ENSMODP00000021625.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	82.87	0.00e+00	858.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MDLDSGLLDH LPNSSANLLC DLGGVTNPLC SSVSPSVTMG KLFFNNRRVS SGEQRQLDTP 60
WSLISMGHGQ TEVPVCVTAG QDPGQPVSDT ELHSQALDQG LEVHLGVVAH MATANSTPPG 120

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Nucleotide Sequence
(Fasta)

CTACTTCATG ATTTTTATTT GTGGCTCAAA ACTTCTTTGC TGCTGAAACT TCCTGGTCAA 60
GGTTTGGCAA GGCAGGTTTT ACTTTCTTTT CTGTTTCAGA AAAGTAAAGG AGAAAGAGGG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002344	Ailuropoda melanoleuca	78.01	0.00e+00	861.00
IUUC-Apl-004202	Anas platyrhynchos	78.99	0.00e+00	875.00
IUUC-Aca-005029	Anolis carolinensis	58.85	7.00e-150	523.00
IUUC-Ame-011841	Astyanax mexicanus	51.22	7.00e-163	567.00
IUUC-Bta-013180	Bos taurus	78.43	0.00e+00	842.00
IUUC-Cja-019813	Callithrix jacchus	81.27	0.00e+00	871.00
IUUC-Cfa-021205	Canis familiaris	83.27	0.00e+00	869.00
IUUC-Cpo-021346	Cavia porcellus	79.28	0.00e+00	849.00
IUUC-Csa-023809	Chlorocebus sabaeus	82.21	0.00e+00	768.00
IUUC-Dre-027669	Danio rerio	59.13	0.00e+00	633.00
IUUC-Dno-029458	Dasypus novemcinctus	78.68	0.00e+00	860.00
IUUC-Dor-030338	Dipodomys ordii	77.69	0.00e+00	772.00
IUUC-Eca-034401	Equus caballus	82.18	0.00e+00	886.00
IUUC-Eeu-034668	Erinaceus europaeus	62.99	1.00e-96	347.00
IUUC-Fca-036057	Felis catus	79.09	0.00e+00	882.00
IUUC-Fal-037560	Ficedula albicollis	74.85	0.00e+00	751.00
IUUC-Gmo-038964	Gadus morhua	63.96	0.00e+00	681.00
IUUC-Gga-040425	Gallus gallus	78.62	0.00e+00	883.00
IUUC-Gac-041908	Gasterosteus aculeatus	66.14	0.00e+00	701.00
IUUC-Ggo-044606	Gorilla gorilla	74.90	0.00e+00	788.00
IUUC-Hsa-046952	Homo sapiens	82.67	0.00e+00	880.00
IUUC-Itr-049016	Ictidomys tridecemlineatus	68.98	0.00e+00	716.00
IUUC-Lch-049571	Latimeria chalumnae	63.73	0.00e+00	754.00
IUUC-Loc-051973	Lepisosteus oculatus	63.38	0.00e+00	656.00
IUUC-Laf-053815	Loxodonta africana	79.37	0.00e+00	835.00
IUUC-Mcc-054888	Macaca mulatta	82.47	0.00e+00	874.00
IUUC-Meu-056547	Macropus eugenii	85.88	0.00e+00	764.00
IUUC-Mga-059819	Meleagris gallopavo	79.80	0.00e+00	832.00
IUUC-Mmu-063133	Mus musculus	79.48	0.00e+00	822.00
IUUC-Mac-064547	Musa acuminata	29.59	2.00e-05	45.10
IUUC-Mpu-065802	Mustela putorius furo	79.10	0.00e+00	860.00
IUUC-Nle-070155	Nomascus leucogenys	82.27	0.00e+00	880.00
IUUC-Opr-070856	Ochotona princeps	73.80	7.00e-102	363.00
IUUC-Ont-071930	Oreochromis niloticus	66.93	0.00e+00	736.00
IUUC-Oni-082966	Oryza nivara	23.50	2.00e-08	53.10
IUUC-Ola-087397	Oryzias latipes	62.94	0.00e+00	714.00
IUUC-Oga-088109	Otolemur garnettii	82.07	0.00e+00	881.00
IUUC-Oar-090310	Ovis aries	70.02	0.00e+00	744.00
IUUC-Ptr-090643	Pan troglodytes	82.67	0.00e+00	883.00
IUUC-Pan-091933	Papio anubis	82.27	0.00e+00	872.00
IUUC-Psi-093681	Pelodiscus sinensis	78.82	0.00e+00	842.00
IUUC-Pfo-096148	Poecilia formosa	62.76	0.00e+00	715.00
IUUC-Pab-098631	Pongo abelii	81.08	0.00e+00	889.00
IUUC-Pca-100582	Procavia capensis	65.89	2.00e-88	319.00
IUUC-Pva-102396	Pteropus vampyrus	67.53	0.00e+00	686.00
IUUC-Rno-106120	Rattus norvegicus	77.49	0.00e+00	806.00
IUUC-Sha-106493	Sarcophilus harrisii	97.61	0.00e+00	1025.00
IUUC-Sar-113570	Sorex araneus	90.06	1.00e-98	353.00
IUUC-Ssc-115843	Sus scrofa	76.95	0.00e+00	862.00
IUUC-Tgu-117144	Taeniopygia guttata	72.27	0.00e+00	726.00
IUUC-Tru-117853	Takifugu rubripes	62.81	0.00e+00	711.00
IUUC-Tni-120256	Tetraodon nigroviridis	67.53	0.00e+00	741.00
IUUC-Tbe-127943	Tupaia belangeri	60.40	1.00e-92	332.00
IUUC-Ttr-129246	Tursiops truncatus	79.41	0.00e+00	838.00
IUUC-Xtr-132279	Xenopus tropicalis	63.47	0.00e+00	637.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence