iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117916

Ensembl Protein ID

ENSTRUP00000031822.1

UniProt Accession

H2U4G0; H2U4G0_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

yrk; fgr

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012570.1	ENSTRUT00000031945.1	ENSTRUP00000031822.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-15	58.2	84	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++ly+y+a ++d+L++kkG++ ++i  ++++++W+++ + ++g +G +P+n+v+ ++
   Q: 84   LFIALYEYDARTEDDLSFKKGEKFHII--NNTEGDWWEARSLDTGNSGYIPSNYVAPVD 140
           5789***********************..8999**********************9987 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCACCKQKK PAKAAAATNP DGGLSAALAQ GRYCPDPIQT IPDFNKGFSS SIVFPSINTH 60
QRPGCLTSTT VCVCVCGVGG GVTLFIALYE YDARTEDDLS FKKGEKFHII NNTEGDWWEA 120

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Nucleotide Sequence
(Fasta)

ATGGGGTGTG CCTGTTGCAA GCAGAAAAAG CCTGCCAAAG CAGCAGCAGC AACATCAGCA 60
ACAGTAGACA TTACAGATCT GTCTCCTAGC AACCCAGACG GAGGATTGTC TGCGGCCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0048246--P:macrophage chemotaxis
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011816	Astyanax mexicanus	81.13	0.00e+00	892.00
IUUC-Dre-028216	Danio rerio	84.71	0.00e+00	919.00
IUUC-Gac-041918	Gasterosteus aculeatus	91.17	0.00e+00	976.00
IUUC-Ont-072409	Oreochromis niloticus	87.43	0.00e+00	923.00
IUUC-Ola-086657	Oryzias latipes	88.87	0.00e+00	956.00
IUUC-Pfo-096519	Poecilia formosa	82.88	0.00e+00	881.00
IUUC-Tni-120886	Tetraodon nigroviridis	91.64	0.00e+00	1010.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence