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Tag Content
UUCD2 ID IUUC-Gga-040218
UUCD1 version UUC-GaG-00415
Ensembl Protein ID ENSGALP00000007405.3
UniProt Accession F1NFN4; F1NFN4_CHICK
Genbank Protein ID ENSGALP00000007405
Protein Name Uncharacterized protein
Genbank Nucleotide ID AADN04000130
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000004655.5 ENSGALT00000007417.4 ENSGALP00000007405.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.00e-128 428.3 406 741
Active Site
Position(s) Description Evidence
710 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 406  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 493
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 494  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYVN 578
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 579  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 666
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 667  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 741
           ******************************99999**************************************76 PP
   
Organism Gallus gallus
Protein Sequence
(Fasta)
MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040218|E3,HECT|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCGAACC CCGGGACGCG TCGGAACGGC TCCAGCATCA AGATCCGCCT CACAGGTAAT 60
AACGGGGCGG GAGGGGCCCT CGCGCGGCCC GGGGCCCTCC TTCGCGCAGA GGGGCCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040218|E3,HECT|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 90.17 0.00e+00 1389.00
IUUC-Apl-004155 Anas platyrhynchos 96.67 0.00e+00 1503.00
IUUC-Aca-005238 Anolis carolinensis 94.89 0.00e+00 1449.00
IUUC-Ame-010901 Astyanax mexicanus 90.70 0.00e+00 1392.00
IUUC-Bta-013221 Bos taurus 88.01 0.00e+00 1333.00
IUUC-Cja-018985 Callithrix jacchus 95.26 0.00e+00 1487.00
IUUC-Cfa-020568 Canis familiaris 93.12 0.00e+00 1434.00
IUUC-Cpo-022531 Cavia porcellus 94.60 0.00e+00 1477.00
IUUC-Csa-024145 Chlorocebus sabaeus 95.83 0.00e+00 1470.00
IUUC-Cho-024963 Choloepus hoffmanni 82.44 0.00e+00 757.00
IUUC-Cin-025126 Ciona intestinalis 62.89 0.00e+00 922.00
IUUC-Csv-026339 Ciona savignyi 62.25 0.00e+00 943.00
IUUC-Dre-028341 Danio rerio 90.71 0.00e+00 1402.00
IUUC-Dno-029705 Dasypus novemcinctus 93.49 0.00e+00 1424.00
IUUC-Dme-031740 Drosophila melanogaster 70.54 4.00e-176 612.00
IUUC-Eca-034125 Equus caballus 94.87 0.00e+00 1446.00
IUUC-Fca-035905 Felis catus 94.57 0.00e+00 1424.00
IUUC-Fal-037336 Ficedula albicollis 96.97 0.00e+00 1449.00
IUUC-Gmo-039486 Gadus morhua 79.74 0.00e+00 868.00
IUUC-Gac-041707 Gasterosteus aculeatus 84.63 0.00e+00 1292.00
IUUC-Ggo-045408 Gorilla gorilla 89.07 0.00e+00 1339.00
IUUC-Hsa-045878 Homo sapiens 95.13 0.00e+00 1485.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 94.73 0.00e+00 1440.00
IUUC-Loc-052628 Lepisosteus oculatus 85.34 0.00e+00 1377.00
IUUC-Laf-053644 Loxodonta africana 90.20 0.00e+00 1369.00
IUUC-Mcc-055479 Macaca mulatta 88.16 0.00e+00 1319.00
IUUC-Mga-059723 Meleagris gallopavo 93.99 0.00e+00 1432.00
IUUC-Mdo-063005 Monodelphis domestica 97.17 0.00e+00 1494.00
IUUC-Mmu-063634 Mus musculus 95.69 0.00e+00 1449.00
IUUC-Mpu-065898 Mustela putorius furo 95.21 0.00e+00 1429.00
IUUC-Mlu-067584 Myotis lucifugus 93.98 0.00e+00 1443.00
IUUC-Nle-069033 Nomascus leucogenys 95.01 0.00e+00 1449.00
IUUC-Ont-072265 Oreochromis niloticus 84.25 0.00e+00 1319.00
IUUC-Oan-073621 Ornithorhynchus anatinus 90.43 0.00e+00 1432.00
IUUC-Ocu-073960 Oryctolagus cuniculus 93.94 0.00e+00 1419.00
IUUC-Oga-088579 Otolemur garnettii 95.13 0.00e+00 1485.00
IUUC-Oar-090396 Ovis aries 91.81 0.00e+00 1350.00
IUUC-Ptr-091624 Pan troglodytes 95.13 0.00e+00 1485.00
IUUC-Pan-092479 Papio anubis 94.74 0.00e+00 1446.00
IUUC-Psi-094074 Pelodiscus sinensis 96.65 0.00e+00 1139.00
IUUC-Pfo-097203 Poecilia formosa 84.38 0.00e+00 1300.00
IUUC-Pab-097540 Pongo abelii 94.77 0.00e+00 1414.00
IUUC-Pca-100379 Procavia capensis 72.20 0.00e+00 634.00
IUUC-Rno-105396 Rattus norvegicus 95.69 0.00e+00 1451.00
IUUC-Sha-107216 Sarcophilus harrisii 95.09 0.00e+00 1474.00
IUUC-Ssc-116413 Sus scrofa 93.52 0.00e+00 1398.00
IUUC-Tgu-116723 Taeniopygia guttata 95.55 0.00e+00 1450.00
IUUC-Tru-117843 Takifugu rubripes 82.03 0.00e+00 1279.00
IUUC-Tsy-119455 Tarsius syrichta 94.35 0.00e+00 1353.00
IUUC-Tni-120037 Tetraodon nigroviridis 82.03 0.00e+00 1235.00
IUUC-Tbe-127879 Tupaia belangeri 80.81 0.00e+00 1177.00
IUUC-Ttr-128423 Tursiops truncatus 93.65 0.00e+00 1369.00
IUUC-Xtr-132237 Xenopus tropicalis 89.02 0.00e+00 1402.00
Created Date 25-Jun-2017

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