iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/Josephin	35.53	1.00e-43	174.00	IUUC-Mmu-063600
UBD/Alpha-Helix/UIM	35.53	1.00e-43	174.00	IUUC-Mmu-063600

Active Site

Position(s)	Description	Evidence
20	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
117	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}
132	N/A	{ECO:0000255\|PROSITE-ProRule:PRU00331}

Organism

Caenorhabditis elegans

Functional Description
(View)

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity).

Protein Sequence
(Fasta)

MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME QQILGNANPT 60
PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY KNNPLTARAY ICNLREHWFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTATCCGTC TTACAAAAAA TATCGATTTT GGCATTCAGC ATGAGGAATA TTATTGTGAA 60
ATCGAAAAAA TAAAACTATT TCCAAGTTTT CTTCTCCAAA ATTTGAGGTG TTTTATTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:0016579--P:protein deubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

cel:CELE_F28F8.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	34.53	1.00e-44	172.00
IUUC-Apl-003210	Anas platyrhynchos	36.64	3.00e-40	157.00
IUUC-Aca-005171	Anolis carolinensis	35.46	8.00e-34	136.00
IUUC-Aly-005625	Arabidopsis lyrata	34.32	2.00e-27	114.00
IUUC-Ath-007088	Arabidopsis thaliana	34.32	2.00e-27	114.00
IUUC-Ame-010715	Astyanax mexicanus	32.41	9.00e-40	155.00
IUUC-Bta-013538	Bos taurus	35.67	4.00e-46	177.00
IUUC-Bdi-015000	Brachypodium distachyon	32.79	2.00e-23	101.00
IUUC-Bol-015894	Brassica oleracea	35.50	2.00e-27	115.00
IUUC-Bra-018020	Brassica rapa	36.59	1.00e-27	116.00
IUUC-Cja-018840	Callithrix jacchus	34.38	6.00e-47	179.00
IUUC-Cfa-021035	Canis familiaris	34.92	2.00e-47	181.00
IUUC-Cpo-021776	Cavia porcellus	34.81	3.00e-44	171.00
IUUC-Csa-023257	Chlorocebus sabaeus	35.93	5.00e-44	170.00
IUUC-Cho-024878	Choloepus hoffmanni	33.44	1.00e-42	165.00
IUUC-Cme-027158	Cyanidioschyzon merolae	28.38	2.00e-09	54.30
IUUC-Dre-027506	Danio rerio	45.76	9.00e-32	129.00
IUUC-Dno-029172	Dasypus novemcinctus	32.59	5.00e-43	167.00
IUUC-Dor-030900	Dipodomys ordii	37.83	3.00e-44	170.00
IUUC-Ete-033000	Echinops telfairi	29.31	6.00e-09	53.50
IUUC-Eca-034338	Equus caballus	34.20	7.00e-45	172.00
IUUC-Eeu-034585	Erinaceus europaeus	46.46	2.00e-23	101.00
IUUC-Fal-037525	Ficedula albicollis	42.77	2.00e-38	151.00
IUUC-Gmo-039718	Gadus morhua	42.62	1.00e-39	155.00
IUUC-Gga-040774	Gallus gallus	35.45	7.00e-42	163.00
IUUC-Gac-041671	Gasterosteus aculeatus	42.08	1.00e-38	152.00
IUUC-Gma-042801	Glycine max	36.02	2.00e-28	118.00
IUUC-Ggo-044759	Gorilla gorilla	34.80	8.00e-38	149.00
IUUC-Hsa-046591	Homo sapiens	37.41	1.00e-45	175.00
IUUC-Hvu-047492	Hordeum vulgare	31.30	3.00e-25	107.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	28.62	9.00e-23	99.00
IUUC-Lch-049519	Latimeria chalumnae	35.02	8.00e-38	149.00
IUUC-Lpe-050819	Leersia perrieri	34.88	1.00e-25	108.00
IUUC-Loc-051816	Lepisosteus oculatus	34.07	9.00e-44	169.00
IUUC-Laf-053784	Loxodonta africana	33.75	1.00e-44	172.00
IUUC-Mcc-055283	Macaca mulatta	34.71	2.00e-46	177.00
IUUC-Meu-056589	Macropus eugenii	31.72	2.00e-36	145.00
IUUC-Mtr-058233	Medicago truncatula	34.36	1.00e-26	112.00
IUUC-Mla-059013	Melampsora laricipopulina	38.29	8.00e-29	119.00
IUUC-Mga-059301	Meleagris gallopavo	33.95	4.00e-44	170.00
IUUC-Mmr-061038	Microcebus murinus	34.60	1.00e-46	179.00
IUUC-Mdo-062927	Monodelphis domestica	36.26	5.00e-43	166.00
IUUC-Mmu-063600	Mus musculus	38.11	6.00e-45	173.00
IUUC-Mpu-065897	Mustela putorius furo	34.49	3.00e-46	177.00
IUUC-Mlu-067543	Myotis lucifugus	34.28	4.00e-45	174.00
IUUC-Nle-069430	Nomascus leucogenys	34.67	9.00e-39	152.00
IUUC-Opr-070550	Ochotona princeps	28.34	5.00e-29	120.00
IUUC-Ont-071723	Oreochromis niloticus	32.81	4.00e-40	157.00
IUUC-Oan-073569	Ornithorhynchus anatinus	36.67	5.00e-44	170.00
IUUC-Ocu-074632	Oryctolagus cuniculus	33.75	1.00e-42	165.00
IUUC-Oba-075288	Oryza barthii	33.72	8.00e-28	116.00
IUUC-Obr-076050	Oryza brachyantha	34.30	4.00e-24	104.00
IUUC-Ogl-077174	Oryza glaberrima	33.72	8.00e-28	116.00
IUUC-Ogu-078006	Oryza glumaepatula	33.72	8.00e-28	116.00
IUUC-Oin-079278	Oryza indica	31.87	2.00e-25	108.00
IUUC-Olo-080941	Oryza longistaminata	33.72	8.00e-28	116.00
IUUC-Ome-081172	Oryza meridionalis	33.72	8.00e-28	116.00
IUUC-Oni-082239	Oryza nivara	33.72	5.00e-28	117.00
IUUC-Opu-083939	Oryza punctata	34.30	2.00e-28	118.00
IUUC-Oru-084393	Oryza rufipogon	33.72	8.00e-28	116.00
IUUC-Osa-086080	Oryza sativa	33.72	5.00e-28	117.00
IUUC-Ola-087566	Oryzias latipes	33.87	4.00e-42	163.00
IUUC-Oga-088617	Otolemur garnettii	28.84	1.00e-25	108.00
IUUC-Oar-090052	Ovis aries	34.29	3.00e-43	167.00
IUUC-Ptr-091435	Pan troglodytes	34.60	1.00e-46	179.00
IUUC-Pan-092742	Papio anubis	35.59	3.00e-43	167.00
IUUC-Psi-093313	Pelodiscus sinensis	36.50	4.00e-42	163.00
IUUC-Pma-094374	Petromyzon marinus	41.85	3.00e-39	154.00
IUUC-Ppa-095601	Physcomitrella patens	36.09	4.00e-31	127.00
IUUC-Pfo-097327	Poecilia formosa	35.85	3.00e-41	160.00
IUUC-Pab-098435	Pongo abelii	33.90	3.00e-42	164.00
IUUC-Pca-101022	Procavia capensis	36.84	4.00e-17	80.90
IUUC-Ppe-101545	Prunus persica	35.54	3.00e-27	114.00
IUUC-Pva-102844	Pteropus vampyrus	35.24	2.00e-48	184.00
IUUC-Rno-104896	Rattus norvegicus	34.70	2.00e-44	171.00
IUUC-Sha-107106	Sarcophilus harrisii	36.86	2.00e-43	167.00
IUUC-Sit-110477	Setaria italica	31.34	8.00e-26	109.00
IUUC-Sly-111416	Solanum lycopersicum	30.28	7.00e-16	75.50
IUUC-Stu-112227	Solanum tuberosum	30.07	5.00e-17	79.30
IUUC-Sar-113534	Sorex araneus	33.99	2.00e-43	168.00
IUUC-Sbi-114751	Sorghum bicolor	31.01	9.00e-26	109.00
IUUC-Ssc-115274	Sus scrofa	35.24	7.00e-47	179.00
IUUC-Tgu-117426	Taeniopygia guttata	34.78	1.00e-39	155.00
IUUC-Tru-118059	Takifugu rubripes	40.31	5.00e-39	153.00
IUUC-Tsy-119448	Tarsius syrichta	35.43	6.00e-26	110.00
IUUC-Tni-120681	Tetraodon nigroviridis	38.76	3.00e-21	92.40
IUUC-Tca-121442	Theobroma cacao	30.00	3.00e-29	120.00
IUUC-Tae-123969	Triticum aestivum	30.19	5.00e-24	103.00
IUUC-Tbe-127638	Tupaia belangeri	30.29	7.00e-32	129.00
IUUC-Ttr-129288	Tursiops truncatus	32.48	6.00e-39	153.00
IUUC-Uma-129359	Ustilago maydis	36.08	1.00e-28	120.00
IUUC-Vpa-130788	Vicugna pacos	34.85	2.00e-44	171.00
IUUC-Vvi-131227	Vitis vinifera	35.15	8.00e-24	102.00
IUUC-Xtr-132147	Xenopus tropicalis	35.24	2.00e-45	174.00
IUUC-Xma-133144	Xiphophorus maculatus	34.71	3.00e-41	160.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence