iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/MIU	42.80	6.00e-109	392.00	IUUC-Hsa-136747
DUB/MINDY	42.80	6.00e-109	392.00	IUUC-Hsa-136747

Active Site

Position(s)	Description	Evidence
139	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
403	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Organism

Drosophila melanogaster

Functional Description
(View)

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

Protein Sequence
(Fasta)

MNEKIVREQR GGEDSPSSVS AKSATAAASA STASMTFASA ALESHKTTTI TTASSSPRTS 60
GASASASSSS RSASAPASSS SQQEKQPMLN ATDMRELREI KQLLWGDNVR EDVFKRWSQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCACTAGTC AATCGATTGG CTGTGCCAAA TAACGCCTCC TGCTATCGAT ATCAATCAAG 60
AAAAAATAAA ATTTATTAAA TAGATTTGTA CATAGGAAAT CGGGTGACGC GAAGCGAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR025257--DUF4205
IPR011992--EF-hand-dom_pair

Pfam

PF13898--DUF4205

SMART

SM01174--DUF4205

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity

KEGG

dme:Dmel_CG7332

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136377	Aegilops tauschii	25.67	5.00e-39	154.00
IUUC-Aml-136379	Ailuropoda melanoleuca	43.19	3.00e-106	377.00
IUUC-Atr-136383	Amborella trichopoda	33.33	1.00e-34	140.00
IUUC-Apl-136385	Anas platyrhynchos	44.08	8.00e-92	329.00
IUUC-Aca-136389	Anolis carolinensis	41.06	1.00e-102	365.00
IUUC-Aly-136394	Arabidopsis lyrata	27.05	5.00e-37	148.00
IUUC-Ath-136396	Arabidopsis thaliana	25.90	7.00e-37	147.00
IUUC-Ani-136403	Aspergillus nidulans	35.00	5.20e-02	32.70
IUUC-Ame-136407	Astyanax mexicanus	44.42	2.00e-112	398.00
IUUC-Bta-136411	Bos taurus	44.54	1.00e-108	385.00
IUUC-Bdi-136416	Brachypodium distachyon	24.82	1.00e-41	163.00
IUUC-Bol-136419	Brassica oleracea	25.96	3.00e-29	122.00
IUUC-Bra-136421	Brassica rapa	26.17	3.00e-30	125.00
IUUC-Cja-136424	Callithrix jacchus	43.91	4.00e-108	384.00
IUUC-Cfa-136428	Canis familiaris	42.92	3.00e-95	340.00
IUUC-Cpo-136432	Cavia porcellus	42.62	3.00e-108	384.00
IUUC-Cre-136436	Chlamydomonas reinhardtii	36.97	3.00e-19	87.40
IUUC-Csa-136438	Chlorocebus sabaeus	44.12	6.00e-108	383.00
IUUC-Cho-136444	Choloepus hoffmanni	46.56	2.00e-82	298.00
IUUC-Cin-136447	Ciona intestinalis	34.96	3.00e-81	294.00
IUUC-Csv-136448	Ciona savignyi	36.11	4.00e-82	297.00
IUUC-Dre-136452	Danio rerio	42.95	2.00e-101	361.00
IUUC-Dno-136456	Dasypus novemcinctus	42.80	6.00e-107	380.00
IUUC-Dor-136461	Dipodomys ordii	43.04	2.00e-87	315.00
IUUC-Ete-136467	Echinops telfairi	35.37	2.00e-76	279.00
IUUC-Eca-136471	Equus caballus	43.91	1.00e-107	382.00
IUUC-Eeu-136476	Erinaceus europaeus	40.76	7.00e-90	323.00
IUUC-Fca-136477	Felis catus	42.59	1.00e-106	379.00
IUUC-Fal-136481	Ficedula albicollis	43.45	7.00e-104	369.00
IUUC-Fox-136484	Fusarium oxysporum	27.66	7.70e-01	28.10
IUUC-Fso-136485	Fusarium solani	28.72	5.80e-01	28.90
IUUC-Gmo-136486	Gadus morhua	40.84	2.00e-98	351.00
IUUC-Gga-136491	Gallus gallus	42.80	8.00e-106	376.00
IUUC-Gac-136495	Gasterosteus aculeatus	40.43	7.00e-100	356.00
IUUC-Gma-136501	Glycine max	26.91	3.00e-40	159.00
IUUC-Ggo-136502	Gorilla gorilla	40.29	8.00e-91	326.00
IUUC-Hsa-136747	Homo sapiens	44.12	6.00e-108	383.00
IUUC-Hvu-136508	Hordeum vulgare	26.75	1.00e-33	135.00
IUUC-Itr-136510	Ictidomys tridecemlineatus	38.27	2.00e-35	141.00
IUUC-Lch-136515	Latimeria chalumnae	43.34	9.00e-108	382.00
IUUC-Lpe-136518	Leersia perrieri	28.38	6.00e-29	121.00
IUUC-Loc-136521	Lepisosteus oculatus	42.98	5.00e-103	367.00
IUUC-Laf-136527	Loxodonta africana	43.91	4.00e-108	384.00
IUUC-Mcc-136530	Macaca mulatta	44.12	6.00e-108	383.00
IUUC-Meu-136534	Macropus eugenii	30.21	4.00e-35	141.00
IUUC-Mtr-136540	Medicago truncatula	29.21	9.00e-40	157.00
IUUC-Mga-136543	Meleagris gallopavo	42.32	2.00e-100	358.00
IUUC-Mmr-136547	Microcebus murinus	43.91	2.00e-107	381.00
IUUC-Mdo-136551	Monodelphis domestica	43.70	1.00e-110	392.00
IUUC-Mmu-136555	Mus musculus	43.40	5.00e-107	380.00
IUUC-Mac-136559	Musa acuminata	27.57	3.00e-36	145.00
IUUC-Mpu-136561	Mustela putorius furo	41.94	3.00e-78	284.00
IUUC-Mlu-136565	Myotis lucifugus	41.72	2.00e-106	378.00
IUUC-Nle-136572	Nomascus leucogenys	44.12	6.00e-108	383.00
IUUC-Opr-136576	Ochotona princeps	31.65	3.00e-45	175.00
IUUC-Ont-136579	Oreochromis niloticus	39.96	1.00e-97	348.00
IUUC-Oan-136582	Ornithorhynchus anatinus	42.86	4.00e-99	354.00
IUUC-Ocu-136585	Oryctolagus cuniculus	43.91	3.00e-107	380.00
IUUC-Oba-136589	Oryza barthii	25.67	4.00e-40	158.00
IUUC-Obr-136592	Oryza brachyantha	25.83	3.00e-39	155.00
IUUC-Ogl-136593	Oryza glaberrima	25.67	3.00e-40	159.00
IUUC-Ogu-136595	Oryza glumaepatula	25.67	5.00e-40	158.00
IUUC-Oin-136597	Oryza indica	25.41	3.00e-37	148.00
IUUC-Olo-136599	Oryza longistaminata	26.11	4.00e-40	158.00
IUUC-Oni-136602	Oryza nivara	25.67	3.00e-40	159.00
IUUC-Opu-136604	Oryza punctata	25.63	3.00e-40	159.00
IUUC-Oru-136606	Oryza rufipogon	25.67	3.00e-40	159.00
IUUC-Osa-136608	Oryza sativa	28.05	2.00e-28	119.00
IUUC-Ola-136610	Oryzias latipes	41.14	1.00e-106	379.00
IUUC-Oga-136614	Otolemur garnettii	43.49	4.00e-108	384.00
IUUC-Oar-136619	Ovis aries	44.33	3.00e-108	384.00
IUUC-Ptr-136623	Pan troglodytes	44.12	1.00e-107	382.00
IUUC-Pan-136627	Papio anubis	44.12	6.00e-108	383.00
IUUC-Psi-136631	Pelodiscus sinensis	46.38	5.00e-91	327.00
IUUC-Pma-136635	Petromyzon marinus	44.37	2.00e-23	100.00
IUUC-Ppa-136638	Physcomitrella patens	28.10	2.00e-35	142.00
IUUC-Pfo-136641	Poecilia formosa	41.98	2.00e-102	365.00
IUUC-Pab-136645	Pongo abelii	43.70	4.00e-108	384.00
IUUC-Pop-136650	Populus trichocarpa	24.91	2.00e-33	136.00
IUUC-Pca-136652	Procavia capensis	48.25	8.00e-62	230.00
IUUC-Ppe-136656	Prunus persica	25.05	8.00e-43	167.00
IUUC-Pva-136658	Pteropus vampyrus	40.34	1.00e-91	329.00
IUUC-Rno-136665	Rattus norvegicus	43.62	3.00e-108	384.00
IUUC-Sha-136671	Sarcophilus harrisii	43.49	1.00e-110	392.00
IUUC-Smo-136678	Selaginella moellendorffii	30.23	4.00e-37	148.00
IUUC-Sit-136680	Setaria italica	27.07	5.00e-32	130.00
IUUC-Sly-136683	Solanum lycopersicum	29.37	8.00e-40	157.00
IUUC-Sar-136685	Sorex araneus	43.95	4.00e-77	280.00
IUUC-Sbi-136688	Sorghum bicolor	26.97	3.00e-38	152.00
IUUC-Ssc-136691	Sus scrofa	44.12	5.00e-108	383.00
IUUC-Tgu-136694	Taeniopygia guttata	43.79	6.00e-102	363.00
IUUC-Tru-136698	Takifugu rubripes	40.50	6.00e-99	353.00
IUUC-Tsy-136703	Tarsius syrichta	41.44	9.00e-101	359.00
IUUC-Tni-136706	Tetraodon nigroviridis	41.01	7.00e-101	360.00
IUUC-Tca-136711	Theobroma cacao	24.91	6.00e-39	154.00
IUUC-Tae-136714	Triticum aestivum	26.11	3.00e-42	165.00
IUUC-Tur-136716	Triticum urartu	24.54	9.00e-28	117.00
IUUC-Tbe-136719	Tupaia belangeri	43.24	1.00e-96	346.00
IUUC-Ttr-136722	Tursiops truncatus	41.60	6.00e-101	360.00
IUUC-Vpa-136729	Vicugna pacos	43.92	7.00e-101	359.00
IUUC-Vvi-136732	Vitis vinifera	25.19	3.00e-39	155.00
IUUC-Xtr-136734	Xenopus tropicalis	39.02	5.00e-88	317.00
IUUC-Xma-136738	Xiphophorus maculatus	40.72	2.00e-102	365.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence